个人简介

Education: Ph.D., Medical Engineering and Medical Physics, Harvard-MIT Division of Health Sciences & Technology, 2013 M. Phil., Engineering Design, The University of Cambridge, 2008 B.S.E., Biomedical Engineering, University of Iowa, 2007

研究领域

The Ankrum Lab is focused on engineering mesenchymal stem cell (MSC) based therapeutics, often with the use of biomaterials, to control cells after transplantation into disease microenvironments in a range of diseases including diabetic wounds, diabetes, multiple sclerosis, and ischemic neuropathies. The lab sits at the intersection of bioengineering, biomaterials, cell biology, and immunology and is composed of scientists and trainees from diverse technical backgrounds.

Cell based therapies, microenvironmental control of cell phenotype, pancreatic beta cell therapy

近期论文

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Function of Cryopreserved Mesenchymal Stromal Cells With and Without Interferon-γ Prelicensing is Context Dependent. Burand, A J, Gramlich, OW, Brown, A J & Ankrum, J. Stem Cell (2016). doi:10.1002/stem.2528 Targeted Strategies to Modulate Stem-Cell-Relevant Pathways. Lowery, J. W., Ankrum JA, Kokabu S, Liu R. Stem Cells International 2016, 1–2 (2016). Cryopreserved Mesenchymal Stromal Cells Maintain Potency in a Retinal Ischemia/Reperfusion Injury Model: Toward an off-the-shelf Therapy Gramlich OW , Burand AJ , Brown AJ, Deutsch RJ, Kuehn MH, Ankrum JA. Rolling circle amplification: a versatile tool for chemical biology, materials science and medicine. Ali MM, Li F, Zhang Z, Zhang K, Kang DK, Ankrum JA, Le XC, Zhao W. Chem Soc Rev. 2014 May 21;43(10):3324-41. doi: 10.1039/c3cs60439j. Epub 2014 Mar 18. PubMed PMID: 24643375. Performance-enhanced mesenchymal stem cells via intracellular delivery of steroids. Ankrum JA, Dastidar RG, Ong JF, Levy O, Karp JM. Sci Rep. 2014 Apr 10;4:4645. doi: 10.1038/srep04645. PubMed PMID: 24717973; PubMed Central PMCID: PMC3982175. Mesenchymal stem cells: immune evasive, not immune privileged. Ankrum JA, Ong JF, Karp JM. Nature Biotechnology. 2014 Mar;32(3):252-60. doi: 10.1038/nbt.2816. Epub 2014 Feb 23. PubMed PMID: 24561556. Engineering cells with intracellular agent-loaded microparticles to control cell phenotype. Ankrum JA, Miranda OR, Ng KS, Sarkar D, Xu C, Karp JM. Nature Protocols. 2014 Feb;9(2):233-45. doi: 10.1038/nprot.2014.002. Epub 2014 Jan 9. PubMed PMID: 24407352. Prodrugs as self-assembled hydrogels: a new paradigm for biomaterials. Vemula PK, Wiradharma N, Ankrum JA, Miranda OR, John G, Karp JM. Curr Opin Biotechnol. 2013 Dec;24(6):1174-82. doi: 10.1016/j.copbio.2013.02.006. Epub 2013 Mar 1. Review. PubMed PMID: 23465753. Microstructured barbs on the North American porcupine quill enable easy tissue penetration and difficult removal. Cho WK, Ankrum JA, Guo D, Chester SA, Yang SY, Kashyap A, Campbell GA, Wood RJ, Rijal RK, Karnik R, Langer R, Karp JM. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21289-94. doi: 10.1073/pnas.1216441109. PMID: 23236138, PMCID: PMC3535670