研究领域

Ongoing research in the Fritzsch laboratory focuses on four main themes: Molecular basis of ear development (currently funded by NIH/NIDCD R01) Molecular basis of inner ear efferent and brainstem motoneuron formation (currently funded as a subcontract of an NIH R01 with Children's Hospital, Boston) Molecular basis of hair cell proliferation, maintenance and regeneration Improving multicolor dye tracing techniques (currently funded by NIH/NIMH SBIR II)

Cell and Developmental Biology, Evolution, Genetics, Neurobiology

近期论文

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Glasco D.M., Pike W., Qu Y., Reustle L., Misra K., Di Bonito M., Studer M., Fritzsch B., Goffinet A.M., Tissir F., Chandrasekhar A. 2016. The atypical cadherin Celsr1 functions non-cell autonomously to block rostral migration of facial branchiomotor neurons in mice. Developmental Biology. 417: 40-49. Fritzsch B., Duncan J.S., Kersigo J., Gray B., Elliott K.L. 2016. Neuroanatomical Tracing Techniques in the Ear: History, State of the Art, and Future Developments. Auditory and Vestibular Research: Methods and Protocols. 1427: 243-262. Yuhki Saito, Soledad Miranda-Rottmann, Matteo Ruggiu, Christopher Y Park, John J Fak, Ru Zhong, Jeremy S Duncan, Brian A Fabella, Harald J Junge, Zhe Chen, Roberto Araya, Bernd Fritzsch, AJ Hudspeth, Robert B Darnell. 2016. NOVA2-mediated RNA regulation is required for axonal pathfinding during development. eLife. 5: e14371. Tetyana Chumak, Romana Bohuslavova, Iva Macova, Nicole Dodd, Daniela Buckiova, Bernd Fritzsch, Josef Syka, Gabriela Pavlinkova. 2016. Deterioration of the medial olivocochlear efferent system accelerates age-related hearing loss in Pax2-Isl1 transgenic mice. Mol Neurobiol. 53: 2368-2383. Romana Bohuslavova, Nicole Dodd, Iva Macova, Tetyana Chumak, Martin Horak, Josef Syka, Bernd Fritzsch, Gabriela Pavlinkova. 2016. Pax2-Islet1 Transgenic Mice Are Hyperactive and Have Altered Cerebellar Foliation. Mol Neurobiol. :1-17. Tian Yang, Elizabeth S Scholl, Ning Pan, Bernd Fritzsch, Françoise Haeseleer, Amy Lee. 2016. Expression and Localization of CaBP Ca 2+ Binding Proteins in the Mouse Cochlea. PloS one. 11: e0147495. YY Szeto, KH Chu, YK Au, YH Huang, S Wynn, A Mak, YS Chan, R Lovell-Badge, WY Chan, R Jauch, B Fritzsch, MH Sham, KSE Cheah. 2016. The SOX9Y440X campomelic dysplasia mutation disrupts endolymph homeostasis. Gordon Research Conference: Fibroblast Growth Factors in Development & Disease. The Chinese University of Hong Kong, Hong Kong, China. Alain Dabdoub, Bernd Fritzsch, Arthur N Popper, Richard R Fay. 2016. The primary auditory neurons of the Mammalian Cochlea: with 58 illustrations. Springer handbook of auditory research. 52. Alain Dabdoub, Bernd Fritzsch. 2016. Connecting the Inner Ear to the Central Auditory System: Molecular Development and Characteristics of the Primary Auditory Neurons and Their Network. The Primary Auditory Neurons of the Mammalian Cochlea. Springer handbook of auditory research. 52:1-10. Bernd Fritzsch, Jennifer Kersigo, Tian Yang, Israt Jahan, Ning Pan. 2016. Neurotrophic Factor Function During Ear Development: Expression Changes Define Critical Phases for Neuronal Viability. The Primary Auditory Neurons of the Mammalian Cochlea. Springer handbook of auditory research. 52:49-84.