研究领域

Microglial cell structure and function in mammalian brain development and pathology. Research in our laboratory seeks to understand the roles of glial cells in mammalian brain development and response to neural injury. Current projects are focused on identifying how specific purinergic signaling pathways regulate microglial cell activation, survival, and mobilization. To address these questions, we utilize confocal and multiphoton imaging methodology in combination with pharmacological and genetic manipulations. Models of brain injury include ischemic stroke and fetal alcohol spectrum disorders in ex vivo cell culture and tissue slice preparations, and in intact brain in vivo.

Cell and Developmental Biology, Neurobiology

近期论文

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Eyo U, Miner S, Weiner JA, and Dailey ME (2016) Developmental changes in microglial mobilization are independent of apoptosis in the neonatal mouse hippocampus. Brain, Behavior, and Immunity 55:49–59. PMID: 26576723. PMCID: PMC4864211. [JIF=5.889] Doddapattar P, Gandhi C, Prakash P, Dhanesha N, Grumbach I, Dailey ME, Lentz SR, and Chauhan AK (2015) Fibronectin splicing variants containing extra domain A promote atherosclerosis in mice through Toll-like receptor 4. Arteriosclerosis, Thrombosis, and Vascular Biology. 35(11):2391-2400. PMID: 26427793. PMCID: PMC4618710. [JIF=6.008] Ahlers KE, Karaçay B, Fuller L, Bonthius DJ, and Dailey ME (2015) Transient activation of microglia following acute alcohol exposure in developing mouse neocortex is primarily driven by BAX-dependent neurodegeneration. Glia. 63(10):1694–1713. PMID: 25856413. PMCID: PMC4534325. [JIF= 6.031] Miakotina O, Dailey ME (2014) Neuroprogenitor Cell Differentiation in Culture. Pp. 256-269 in Tested Studies for Laboratory Teaching, Vol. 35 (K. McMahon, Editor). Proceedings of the 35th Conference of the Assoc. for Biology Laboratory Education (ABLE), 242 pages. Dailey ME, Eyo U, Fuller L, Hass J, Kurpius D. (2013) Imaging microglia in brain slices and slice cultures. Cold Spring Harb Protoc; Dec. 2; pp. 1142-1148. doi:10.1101/pdb.prot079483. PMID: 24298036. Eyo U, Dailey ME (2013) Microglia: Key Elements in Neural Development, Plasticity, and Pathology. J. Neuroimmune Pharmacol. 8:494-509. PMID: 23354784. [JIF: 4.574]. Eyo UB, Miner SA, Ahlers KE, Wu L-J, Dailey ME (2013) P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation. Neuropharmacology 73:311–319. PMID: 23770338. PMCID: PMC3786777. [JIF: 4.114] Eyo U, Dailey ME (2012) Effects of oxygen-glucose deprivation on microglial motility and viability in developing mouse hippocampal tissues. Glia 60(11):1747-1760. PMID: 22847985. PMCID: PMC3786781. [JIF: 5.186] Benediktsson AM, Marrs GM, Tu JC, Worley PF, Rothstein JD, Bergles DE, and Dailey ME (2012) Neuronal activity regulates glutamate transporter dynamics in developing astrocytes. Glia 60(2):175-188. PMID: 22052455. PMC3232333. [JIF: 5.186]