朱海燕 - 复旦大学

个人简介

教育经历 1991.09 – 2002.07 黑龙江中医药大学本科，硕士，博士 2002.09 – 2004.08 中国科学院上海药物研究所博士后工作经历 2004.09 – 2006.11 中国科学院上海药物研究所，天然药物课题组，副研究员 2006.11- 2015.12 复旦大学药学院，生物药学系（原微生物与生化药学教研室）抗病毒药物研究室，讲师 2016.1-至今复旦大学药学院，生物药学系（原微生物与生化药学教研室）抗病毒药物研究室，副教授

研究领域

抗病毒中药活性发现、药效评价及药物作用机制研究抗感染药物的宿主屏障保护及免疫调控机制研究

近期论文

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Linfeng Guo, Weilian Bao, Shuiyuan Yang , Yang Liu , Jiaren Lyu, Ting Wang, Yan Lu, Hong Li, Haiyan Zhu *, Daofeng Chen* . Rhei Radix et Rhizoma in Xuanbai-Chengqi decoction strengthens the intestinal barrier function and promotes lung barrier repair in preventing severe viral pneumonia induced by influenza A virus. J ournal of Ethnopharmacol，2023，30:117231. Chenchen Shi, Chang Su, Lifeng Cen, Lei Han, Jianguo Tang, Ze tian Wang, Xunlong Shi, Dian wen Ju, Yiou Cao *, Haiyan Zhu *. Vunakizumab-IL22, a novel fusion protein, promotes intestinal epithelial repair and protects against gut injury induced by the influenza virus. Biomedicines，2023, 11(4)：1160. YuanZhen Hao, LiFeng Cen, Ting Wang, Tong Yi, Xun-Long Shi, HuiJuan Duan, Zhi Dai, HaiYan Zhu*, JianGuo Tang*. The protective effect of 999 XiaoErGanMao granules on the lungs and intestines of influenza A virus-infected mice.Pharmaceutical biology，2023,61(1): 630-638. Chenchen Shi, Lishuang Zhou, Hong Li, Xunlong Shi, Yunyi Zhang, Yan Lu, Haiyan Zhu*, Daofeng Chen*.Intestinal microbiota metabolizing Houttuynia cordata polysaccharides in H1N1 induced pneumonia mice contributed to Th17/Treg rebalance in gut-lung axis. International journal of biological macromolecules,2022，221:288-302. Jinlin Huo, Ting Wang, Bokai Wei, Xunlong Shi, Aidong Yang, Daofeng Chen, Jing Hu, Haiyan Zhu*.Integrated network pharmacology and intestinal flora analysis to determine the protective effect of Xuanbai-Chengqi decoction on lung and gut injuries in influenza virus-infected mice.Journal of ethnopharmacology，2022,298:115649. Rong Tian, Haiyan Zhu*, Yan Lu , Xunlong Shi , Peng Tu , Hong Li , Hai Huang , Daofeng Chen*. Therapeutic potential of 2-Methylquinazolin-4(3H)-one as an antiviral agent against influenza A virus-induced acute lung injury in mice.Molecules, 2022, 27(22):7857. Zetian Wang, Liping Yin, Yue Qi, Jiali Zhang, Haiyan Zhu*, Jianguo Tang *.Intestinal Flora-Derived Kynurenic Acid Protects Against Intestinal Damage Caused by Infection Activation of Aryl Hydrocarbon Receptor. Frontiers in microbiology，2022,DOI ：10.3389/fmicb.2022.934786 Tong Yi , Wenxin Ding, Yuanzhen Hao, Lifeng Cen, Jiyang Li, Xunlong Shi, Ting Wang, Daofeng Chen, Haiyan Zhu*.?Neutrophil extracellular traps mediate severe lung injury induced by influenza A virus H1N1 in mice coinfected with Staphylococcus aureus. Microbial pathogenesis，2022,27:166. Lifeng Cen, Tong Yi, Yuanzhen Hao, Chenchen Shi, Xunlong Shi, Yan Lu, Daofeng Chen, Haiyan zhu*. Houttuynia Cordata Polysaccharides alleviate the ulcerative colitis by restoring the intestinal homeostasis. Chinese Journal of Natural Medicines. 2022,DOI:10.1016/S1875- 5364 (22) 60 220-6 Lei Han, Chenchen Shi, Xian Zeng, Lifeng Cen, Xiaobin Mei, Jiajun Fan, Dianwen Ju, Haiyan Zhu*. A novel bifunctional fusion protein, vunakizumab-IL22, for protection against pulmonary immune injury caused by influenza virus. Frontiers in Immunology, 2021, doi: 10.3389/ fimmu.2021.727941 Chenchen Shi, Haiyan Zhu*, Hong Li, Donglin Zeng, Xunlong Shi, Yunyi Zhang, Yan Lu, Lijun Ling, Changyue Wang, Daofeng Chen*. Regulating the Balance of Th17/Treg cells in Gut-Lung Axis Contributed to the Therapeutic Effect of Houttuynia cordata Polysaccharides on H1N1-induced Acute Lung Injury. International Journal of Biological Macromolecules，2020,158,52-66. PingGeng #, Haiyan Zhu#, Wei Zhou, Chang Su, Mingcang Chen, Chenggang Huang, Chengjie Xia, Hai Huang, Yiou Cao, Xunlong Shi*. Baicalin inhibits influenza A virus infection via amplification of M1 macrophage polarization. Frontiers in Pharmacology, 2020,11, doi: 10.3389/fphar.2020.01298. Haiyan Zhu, Xiaoxiao Lu, Lijun Ling, Hong Li , Yingye Ou , Xunlong Shi, Yan Lu , Yunyi Zhang, Daofeng Chen. Houttuynia cordata polysaccharides ameliorate pneumonia severity and intestinal injury in mice with influenza virus infection. J Ethnopharmacol. 2018，23;218:90-99.