Chen, Lingling - Indiana University - Department of Biology

个人简介

B.S. (1988) Xiamen University - Physical Chemistry Ph.D. (1996) Stanford University - Chemistry Helen Hay Postdoctoral Fellow (1997-2000) Yale University - Protein Crystallography

研究领域

microbial structure, function and mechanism; biology of molecular chaperone (chaperonin)

近期论文

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Melissa Illingworth, Jared Salisbury, Wenqian Li, Donghai Lin, and Lingling Chen. Effective ATPase Activity and Moderate Chaperonin-Cochaperonin Interaction Are Important for the Functional Single-Ring Chaperonin System. Biochem. Biophys. Res. Commun. In press, 2015 Yi Pan, Yi Wang, Clay Fuqua, and Lingling Chen. In vivo Analysis of DNA Binding and Ligand Interaction of BlcR, an IclR-type Repressor from Agrobacterium tumefaciens. Microbiology-SGM, 159:814-822, 2013 Zhida Zheng, Clay Fuqua, and Lingling Chen. The binding site of DNA on quorum-sensing transcript factor TraR does not overlap with that of the Anti-Activator. Biochem. Biophys. Res. Commun. 418:396-401, 2012 Zhida Zheng, Dejian Ma, Timothy Yahr, and Lingling Chen. The Transiently Ordered Regions in Intrinsically Disordered ExsE Are Correlated with Structural Elements Involved in Chaperone Binding. Biochem. Biophys. Res. Commun. 417: 129-134, 2012 Melissa Illingworth, Andrew Ramsey, Zhida Zheng, and Lingling Chen. Stimulating the substrate folding activity of a single-ring GroEL variant by modulating the cochaperonin GroES. J. Biol. Chem. 286: 30401-8, 2011 Yi Pan, Valena Fiscus, Wuyi Meng, Zhida Zheng, Lianhui Zhang, Clay Fuqua, and Lingling Chen. The Agobacterium tumefaciens Transcriptional Factor BlcR Is Regulated via Oligomerization. J. Biol. Chem. 286: 20431-40, 2011 Mair Churchill and Lingling Chen. Structural Basis of Acyl-homoserine Lactone-Dependent Signaling. Chem. Rev. 111: 68-85, 2011 Lingling Chen. Signal Synthesis for a Rapid Response. Structure, 18: 1072-1073, 2010 Yali Li, Zhida Zheng, Andrew Ramsey, and Lingling Chen. Analysis of Peptides and Proteins in Their Binding to GroEL, J. Pept. Sci. 12: 693-700, 2010 Yali Li, Xinfeng Gao and Lingling Chen. GroEL Recognizes an Amphipathetic Helix and Binds to the Hydrophobic Side. J. Biol. Chem. 284: 4324-4331, 2009 Guozhou Chen, Phillip Jeffery, Clay Fuqua, Yigong Shi and Lingling Chen. Structural basis of TraM anti-activation of quorum sensing transcription factor TraR. Proc. Natl. Acad. Sci. USA, 104:16474-16479, 2007 Simran Banga, Ping Gao, Xihui Shen, Valena Fiscus, Wei-Xing Zong, Lingling Chen, and Zhao-Qing Luo. Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family. Proc. Natl. Acad. Sci. USA 104:5121-5126, 2007 Zhida Zheng, Guozhou Chen, Evan D. Brutinel, Timothy L. Yahr, and Lingling Chen. Biochemical characterization of a regulatory cascade controlling transcription of the Pseudomonas aeruginosa type III secretion system. J. Biol. Chem. 282:6136-6142, 2007 Guozhou Chen, Chao Wang, Clay Fuqua, Lian-Hui Zhang and Lingling Chen. The crystal structure and mechanism of TraM2, a second quorum sensing antiactivator of Agrobacterium tumefaciens strain A6. J. Bact. 188:8244-8251, 2006 Guinevere Lykken, Guozhou Chen, Evan Brutinel, Lingling Chen, and Timothy Yahr. Characterization of ExsC and ExsD self-association and heterocomplex formation. J. Bact. 188:6832-6840, 2006 Chao Wang, Hai-Bao Zhang, Guozhou Chen, Lingling Chen and Lian-Hui Zhang. Dual control of quorum sensing by two TraM-type antiactivators in Agrobacterium tumefaciens octopine strain A6. J. Bact. 188, 2435-2445, 2006 Guozhou Chen, James Malenkos, Mee-Rye Cha, Clay Fuqua and Lingling Chen. Quorum-sensing antiactivator TraM forms a dimer that dissociates to inhibit TraR. Mol. Micro. 52:1641-1651, 2004 Jiming Wang and Lingling Chen. Domain motions in GroEL upon binding of an oligopeptide. J. Mol. Biol. 334:489-499, 2003 Lingling Chen and Paul Sigler. Crystal structure of a GroEL/peptide complex: plasticity as a basis for substrate diversity. Cell 99:757-768, 1999 Lingling Chen, Gudrun Wildegger, Thomas Kiefhaber, Keith O. Hodgson and Sebastian Doniach. Kinetics of lysozyme refolding: structural characterization of a non-specifically collapsed state using time-resolved x-ray scattering. J. Mol. Biol. 276:225-237, 1998 Lingling Chen, Keith O. Hodgson and Sebastian Doniach. A lysozyme folding intermediate revealed by solution x-ray scattering. J. Mol. Biol. 261:658-671, 1996 Sigurd M. Wilbanks*, Lingling Chen*, David B. McKay, Hirotsugu Tsuruta, and Keith O. Hodgson. Solution Small-angle X-ray Scattering Study of A Bovine Heat-Shock Cognate and Its Subfragments. Biochemistry 34:12095-12106, 1995. (*these two authors contributed equally to this work) Lingling Chen, Narasaiah Gavini, Hirotsugu Tsuruta, David Eliezer, Barbara K. Burgess, Sebastian Doniach, and Keith O. Hodgson. MgATP-induced conformational changes in the iron protein from Azotobactor vinelandii, as studied by small angle x-ray scattering. J. Bio. Chem. 269:3290-3294, 1994 Weizheng Weng, Jiyang Yan, Jungxiu Cai, Shenjun Dai, Shoujing Cao, Lingling Chen, and Huilin Wan. Chemical trapping and DRFTIR study of mechanism of by-products formation in selective (Amm) oxidation of propylene on MoO3 and g-Bi2MoO6. Chemical Journal of Chinese Universities 12:106-110, 1991