毛有东 - 北京大学

个人简介

毛有东博士现任物理学院和定量生物学中心长聘正教授，北大清华联合生命科学中心PI，北大未来技术学院国家生物医学成像科学中心兼职教授，博士生导师。2021年获国家杰出青年科学基金支持。他的实验室主要从事软凝聚态和生物物理的前沿交叉研究，致力于发展四维冷冻电子显微镜方法学，研究软物质动力学和非平衡统计物理生物学，及其在分子医学中的重大应用。教育经历： 1999.9 - 2005.7 北京大学软凝聚态和生物物理博士学位研究生(博士)毕业 1995.9 - 1999.7 武汉大学物理学学士学位本科(学士) 工作经历： 2022.2 - 至今北京大学物理学院长聘正教授 2021.2 - 2022.1 北京大学物理学院研究员，长聘副教授 2015.1 - 2021.1 北京大学物理学院研究员、助理教授科研项目软物质动力和四维冷冻电镜利用冷冻电镜分析生物大分子动力学的新型算法研究超高分辨冷冻电子显微镜成像方法研究与应用

研究领域

物理生物学

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Shuwen Zhang, Shitao Zou, Deyao Yin, Lihong Zhao, Daniel Finley, Zhaolong Wu and Youdong Mao.USP14-regulated allostery of the human proteasome by time-resolved cryo-EM.Nature,605,567-574,2022,10.1038/s41586-022-04671-8 Shijian Zhang, Kunyu Wang, Wei Li Wang, Hanh T Nguyen, Shuobing Chen, Maolin Lu, Eden P Go, Haitao Ding, Robert T Steinbock, Heather Desaire, Joseph Sodroski and Youdong Mao.Asymmetric Structures and Conformational Plasticity of the Uncleaved Full-Length Human Immunodeficiency Virus Envelope Glycoprotein Trimer.J. Virol.,95,e0052921,2021,10.1128/JVI.00529-21 Humayun Sharif, Li Wang, Wei Li Wang, Venkat Giri Magupalli, Liudmila Andreeva, Qi Qiao, Arthur V. Hauenstein, Zhaolong Wu, Gabriel Núñez, Youdong Mao and Hao Wu.Structural mechanism for NEK7-mediated NLRP3 inflammasome activation.Nature,570,338-343,2019 Robustness of signal detection in cryo-electron microscopy via a bi-objective-function approach.BMC Bioinformatics,20,169,2019 Yuanchen Dong, Shuwen Zhang, Zhaolong Wu, Xuemei Li, Wei Li Wang, Yanan Zhu, Svetla Stoilova-McPhie, Ying Lu, Daniel Finley and Youdong Mao.Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome.Nature,565,49-55,2018,10.1038/s41586-018-0736-4 Yanan Zhu, Wei Li Wang, Daqi Yu, Qi Ouyang, Ying Lu and Youdong Mao.Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome.Nat. Commun.,9,1360,2018,10.1038/s41467-018-03785-w Yuanchen Dong, Shuobing Chen, Shijian Zhang, Joseph Sodroski, Zhongqiang Yang, Dongsheng Liu and Youdong Mao.Folding DNA into a lipid-conjugated nanobarrel for controlled reconstitution of membrane proteins.Angew. Chem. Int. Ed.,57,2072-2076,2018,10.1002/anie.201710147 Jiayi Wu, Yong-Bei Ma, Charles Congdon, Bevin Brett, Shuobing Chen, Yaofang Xu, Qi Ouyang and Youdong Mao.Massively parallel unsupervised single-particle cryo-EM data clustering via statistical manifold learning.PLos One,12,e0182130,2017 Yanan Zhu, Qi Ouyang and Youdong Mao.A deep convolutional neural network approach to single-particle recognition in cryo-electron microscopy.BMC Bioinformatics,18,348,2017,10.1186/s12859-017-1757-y Ying Lu, Jiayi Wu, Yuanchen Dong, Shuobing Chen, Shuangwu Sun, Yong-Bei Ma, Qi Ouyang, Daniel Finley, Marc W Kirschner and Youdong Mao.Conformational landscape of the p28-bound human proteasome regulatory particle.Molecular Cell,67,322-333,2017 Shuobing Chen, Jiayi Wu, Ying Lu, Yong-Bei Ma, Byung-Hoon Lee, Zhou Yu, Qi Ouyang, Daniel J Finley, Marc W Kirschner and Youdong Mao.Structural basis for dynamic regulation of the human 26S proteasome.Proc Natl Acad Sci U S A,113,12991-12996,2016,10.1073/pnas.1614614113 Liman Zhang, Shuobing Chen, Jianbin Ruan, Jiayi Wu, Alexander B. Tong, Qian Yin, Yang Li, Liron David, Alvin Lu, Wei Li Wang, Carolyn Marks, Qi Ouyang, Xinzheng Zhang, Youdong Mao and Hao Wu.Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.Science,350,404-409,2015,10.1126/science.aac5789

学术兼职

北京大学物理学院和定量生物学中心长聘正教授，北大清华联合生命科学中心PI，北大未来技术学院国家生物医学成像科学中心兼职教授。