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个人简介

教育背景 2007-2012 清华大学化学系,理学博士 2003-2007 清华大学环境科学与工程系(环境学院),工学学士 工作履历 2020-至今 清华大学精密仪器系 副教授 2017-2020 清华大学精密仪器系,助理教授 2013-2017 美国普渡大学生物医学工程系,博士后

研究领域

主要研究质谱仪器及生物医学应用,具体包括: (1)化学、生命科学和医学应用导向的质谱仪器研发及系统集成 (2)基于质谱的高灵敏度生物分子精细结构解析技术 (3)新型原位离子化(ambient ionization)装置 (4)面向代谢物结构分析的单细胞质谱方法及装置

近期论文

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Guo, X., Bai, H., Ma, X., Li, J., Ren, Y., Ouyang, Z., & Ma, Q. Online coupling of an electrochemically fabricated solid-phase microextraction probe and a miniature mass spectrometer for enrichment and analysis of chemical contaminants in infant drinks. Analytica Chimica Acta 2020, 1098, 66-74. Li, H., Cao, W., Ma, X., Xie, X., Xia, Y., & Ouyang, Z.*. Visible-Light Driven [2+ 2] Photocycloadditions between Benzophenone and C= C Bonds in Unsaturated Lipids. Journal of the American Chemical Society 2020, 142(7), 3499-3505. Cao, W., Cheng, S., Yang, J., Feng, J., Zhang, W., Li, Z., ... & Ma, X.*. Large-scale lipid analysis with C= C location and sn-position isomer resolving power. Nature Communications 2020, 11(1), 1-11. Ma, X., Xia, Y. (2020). Unsaturated Lipid Analysis via Coupling the Paternò–Büchi Reaction with ESI-MS/MS. Lipidomics: Current and Emerging Techniques, 7, 148. 马潇潇,胡清源,瑕瑜. Paternò-Büchi(PB)反应与串联质谱结合实现不饱和脂质精确结构解析[J].分析测试学报,2020,39(1):19-27. Yang, J.; Zhang, W.; Zhang, H.; Zhong, M.; Cao, W.; Li, Z.; Huang, X.; Nie, Z.; Liu, J.; Li, P.; Ma, X.*; Ouyang, Z.*, Polydopamine-Modified Substrates for High-Sensitivity Laser Desorption Ionization Mass Spectrometry Imaging. ACS Applied Materials & Interfaces 2019, 11 (49), 46140-46148. Zhao, Y.; Chen, Z.; Wu, Y.; Tsukui, T.; Ma, X.; Zhang, X.; Chiba, H.; Hui, S.-P., Separating and Profiling Phosphatidylcholines and Triglycerides from Single Cellular Lipid Droplet by In-Tip Solvent Microextraction Mass Spectrometry. Anal. Chem. 2019, 91 (7), 4466-4471. (Cover Article) Zhao, X.; Chen, J.; Zhang, W.; Yang, C.; Ma, X.*; Zhang, S.; Zhang, X., Lipid Alterations during Zebrafish Embryogenesis Revealed by Dynamic Mass Spectrometry Profiling with C=C Specificity. J. Am. Soc. Mass Spectrom. 2019. Su, Y.; Ma, X.; Page, J.; Shi, R.; Xia, Y.; Ouyang, Z.*, Mapping lipid C=C location isomers in organ tissues by coupling photochemical derivatization and rapid extractive mass spectrometry. Int. J. Mass Spectrom. 2019, 445. Feng, J.; Zhang, X.; Huang, L.; Yao, H.; Yang, C.; Ma, X.; Zhang, S.; Zhang, X., Quantitation of Glucose-phosphate in Single Cells by Microwell-Based Nanoliter Droplet Microextraction and Mass Spectrometry. Anal. Chem. 2019, 91 (9), 5613-5620. Cheng, S.; Cao, W.; Zhao, X.; Li, N.; Ouyang, Z.; Ma, Q.*; Ma, X.*, Fast screening of prohibited chemicals in plastic toys using ambient ionization mass spectrometry. Int. J. Mass Spectrom. 2019, 444, 116176. Zhao, X.; Zhao, Y.; Zhang, L.; Ma, X.*; Zhang, S.; Zhang, X.*, Rapid Analysis of Unsaturated Fatty Acids on Paper-Based Analytical Devices via Online Epoxidation and Ambient Mass Spectrometry. Anal. Chem. 2018, 90 (3), 2070-2078. Zhang, X.-C.; Zang, Q.; Zhao, H.; Ma, X.; Pan, X.; Feng, J.; Zhang, S.; Zhang, R.; Abliz, Z.*; Zhang, X.*, Combination of Droplet Extraction and Pico-ESI-MS Allows the Identification of Metabolites from Single Cancer Cells. Anal. Chem. 2018, 90 (16), 9897-9903. Yang, J.; Zhang, H.; Jia, J.; Zhang, X.; Ma, X.*; Zhong, M.*; Ouyang, Z.*, Antireflection Surfaces for Biological Analysis Using Laser Desorption Ionization Mass Spectrometry Research 2018, 2018, 13. Tang, F.; Guo, C.; Ma, X.; Zhang, J.; Su, Y.; Tian, R.; Shi, R.; Xia, Y.; Wang, X.; Ouyang, Z., Rapid In Situ Profiling of Lipid C=C Location Isomers in Tissue Using Ambient Mass Spectrometry with Photochemical Reactions. Anal. Chem. 2018, 90 (9), 5612-5619. Su, Y.; Ma, X.*; Ouyang, Z.*, Rapid screening of multi-class antimicrobial residues in food of animal origin by paper spray mass spectrometry. Int. J. Mass Spectrom. 2018, 434, 233-239. Guo, X.; Bai, H.; Lv, Y.; Xi, G.; Li, J.; Ma, X.; Ren, Y.; Zheng, O.; Ma, Q., Rapid identification of regulated organic chemical compounds in toys using ambient ionization and a miniature mass spectrometry system. Talanta 2018, 180, 182-192. Cao, W.; Ma, X.*; Li, Z.; Zhou, X.; Ouyang, Z.*, Locating Carbon-Carbon Double Bonds in Unsaturated Phospholipids by Epoxidation Reaction and Tandem Mass Spectrometry. Anal. Chem. 2018, 90 (17), 10286-10292. Zhao, Y.; Zhao, H.; Zhao, X.; Jia, J.; Ma, Q.; Zhang, S.; Zhang, X.; Chiba, H.; Hui, S.-P.*; Ma, X.*, Identification and Quantitation of C=C Location Isomers of Unsaturated Fatty Acids by Epoxidation Reaction and Tandem Mass Spectrometry. Anal. Chem. 2017, 89 (19), 10270-10278. Li, J.; Condello, S.; Thomes-Pepin, J.; Ma, X.; Xia, Y.; Hurley, T. D.; Matei, D.; Cheng, J.-X., Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells. Cell Stem Cell 2017, 20 (3), 303-+. Durand, K. L.; Tan, L.; Stinson, C. A.; Love-Nkansah, C. B.; Ma, X.; Xia, Y., Assigning Peptide Disulfide Linkage Pattern Among Regio-Isomers via Methoxy Addition to Disulfide and Tandem Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2017, 28 (6), 1099-1108. Ma, X.#; Chong, L.#; Tian, R.; Shi, R.; Hu, T. Y.; Ouyang, Z.; Xia, Y., Identification and quantitation of lipid C=C location isomers: A shotgun lipidomics approach enabled by photochemical reaction. Proc. Natl. Acad. Sci. U. S. A. 2016, 113 (10), 2573-2578. (Featured by Purdue News, C&E News, Nature Methods) Zhao, Y.; Wei, Z.; Zhao, H.; Jia, J.; Chen, Z.; Zhang, S.; Ouyang, Z.*; Ma, X.*; Zhang, X.*, In Situ Ion-Transmission Mass Spectrometry for Paper-Based Analytical Devices. Anal. Chem. 2016, 88 (22), 10805-10810. Ma, X.; Zhao, X.; Li, J.; Zhang, W.; Cheng, J.-X.; Ouyang, Z.*; Xia, Y.*, Photochemical Tagging for Quantitation of Unsaturated Fatty Acids by Mass Spectrometry. Anal. Chem. 2016, 88 (18), 8931-8935. Ma, X.; Ouyang, Z.*, Ambient ionization and miniature mass spectrometry system for chemical and biological analysis. Trac-Trends in Analytical Chemistry 2016, 85, 10-19. Ma, X.; Xia, Y.*, Pinpointing Double Bonds in Lipids by Paterno-Buchi Reactions and Mass Spectrometry. Angew. Chem. Int. Ed. 2014, 53 (10), 2592-2596. (Frontispiece Cover)

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