个人简介
李薇博士2002年在北京大学生命科学学院获得学士学位，2009年在美国加利福尼亚州大学戴维斯分校获遗传学博士学位，之后在美国加利福尼亚州大学旧金山分校从事博士后研究。2011-2013年在中国科学院生物物理研究所担任副研究员，2013年加入清华大学医学院担任副研究员。
研究领域
研究神经细胞发育的调控机制
以线虫胚胎和神经前体细胞为对象，发展了活体荧光显微成像方法和基于CRISPR-Cas9的条件性基因突变方法，研究细胞的分裂模式和细胞分化机制，神经前体细胞发育的调控机制。
近期论文
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1. Xie C, Jiang Y, Huang S, Li W*, Ou G*. Actin Filament Debranching Regulates Cell Polarity during Cell Migration and Asymmetric Cell Division. Proceedings of the National Academy of the Sciences of the United States of America, 2021. 118(37). (*Correspondence author)
2. Jia R, Chai Y, Xie C, Liu G, Zhu Z, Huang K, Li W*, Ou G*. The spectrin-based membrane skeleton is asymmetric and remodels during neural development in C. elegans. J Cell Sci, 2020. 133(15). (*Correspondence author)
3. Li W, Li M, Ou G. COVID-19, cilia, and smell. FEBS J., 2020 Sep; 287(17): 3672–3676.
4. Wu D, Chai Y, Zhu Z, Li W, Ou G, Li W. CED-10-WASP-Arp2/3 signaling axis regulates apoptotic cell corpse engulfment in C. elegans. Dev Biol. 2017;428(1):215-223
5. Li W* and Ou G. The Application of Somatic CRISPR-Cas9 to Conditional Genome Editing in Caenorhabditis elegans. Genesis. 2016;54(4): p. 170-81. 2.
6. Yi P, Li W*, Ou G*. The application of transcription activator-like effector nucleases for genome editing in C. elegans. Methods. 2014, 68(3):389-96. (*Correspondence author)
7. Cheng Z#, Yi P#, Wang X, Chai Y, Feng G, Yang Y, Liang X, Zhu Z, Li W*, and Ou G*. Conditional targeted genome editing using somatically expressed TALENs in C. elegans. Nature Biotechnology. 2013, 31(10):934-7. (*Correspondence author)
8. Chai Y#, Li W#, Feng G, Yang Y, Wang X and Ou, G*. Live Imaging of Cellular Dynamics during C. elegans Postembryonic Development. Nature Protocols. 2012, 7(12):2090-102. (#Co-first author)
9. Li W, Stuurman N, Ou G. Chromophore-assisted laser inactivation in neural development. Neuroscience Bulletin. 2012, 28(4): 333–341.
10. Li W#, Zou W#, Yang Y#, Chai Y#, Chen B, Cheng S, Tian D, Wang X*, Vale RD* and Ou, G*. Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell. Journal of Cell Biology. 2012, 197(1):27-35. (#Co-first author)
11. Li W, DeBella LR, Guven-Ozkan T, Lin R, and Rose LS. An eIF4E-binding protein regulates katanin protein levels in C. elegans embryos. Journal of Cell Biology. 2009; 187:33-42.
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