王宏伟 - 清华大学 - 生命科学学院

个人简介

王宏伟博士，教授，博士生导师。教育背景： 1992-1996 清华大学生物科学与技术系，学士 1996-2001 清华大学生物科学与技术系，博士工作经历： 2001-2006 美国劳伦斯伯克利国家实验室生命科学部，博士后 2006-2008 美国劳伦斯伯克利国家实验室生命科学部，研究科学家 2009-2011 美国耶鲁大学分子生物物理与生物化学系，Tenure-Track助理教授 2010.12-至今清华大学生命科学学院，教授、博导 2016.04-2021.04 清华大学生命科学学院院长学术成果：在Nature、Science、Cell、Nat Commun、Proc Natl Acad Sci USA、Mol Cell等国际期刊上发表了多篇高水平论文，推动了冷冻电镜技术的发展及其在生物大分子结构解析中的应用。代表性成果包括开发了基于石墨烯的冷冻电镜样品制备技术、研究了微管组装的GTP启动机制、解析了植物NLR抗病复合体的结构等。获奖情况：担任多项重要科研项目负责人，推动冷冻电镜技术在生命科学领域的广泛应用。

研究领域

利用冷冻电子显微学研究生物大分子复合体的结构与分子机理。主要研究方向如下： 1. 更高效、更高分辨率的冷冻电镜方法学开发； 2. 核酸质量控制的分子机制和调控； 3. 细胞骨架和生物膜系统的协调机制。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Zheng, LM, Xu J, Wang W, Gao X, Zhao C, Guo W, Sun L, Cheng H, Meng F, Chen B, Sun W, Jia X, Zhou X, Wu K, Liu Z, Ding F, Liu N*, Wang HW*, Peng HL*. (2024) Self-assembled superstructure alleviates air-water interface effect in cryo-EM. Nat Commun., 15(1):7300. 2. Yang Z, Fan J, Wang J, Fan X, Ouyang Z*, Wang HW*, Zhou XY*. (2024) Electrospray-assisted cryo-EM sample preparation to mitigate interfacial effects. Nat Methods, 21(6):1023-1032. 3. Xu J, Gao XY, Zheng LM, Jia X, Xu K, Ma Y, Wei XD, Liu N*, Peng HL*, Wang HW*. (2024) Graphene sandwich-based biological specimen preparation for cryo-EM analysis. Proc Natl Acad. Sci USA, 121(5):e2309384121. 4. Zhou J, Wang A, Song Y, Liu N, Wang J, Li Y, Liang X, Li GH, Chu HY, Wang HW*. (2023) Structural insights into the mechanism of GTP initiation of microtubule assembly. Nat. Commun., 14(1):5980. 5. You X, Zhang X, Cheng J, Xiao YN, Ma JF, Sun S, Zhang XZ*, Wang HW*, Sui SF*. (2023) In situ structure of the red algal phycobilisome–PSII–PSI–LHC megacomplex. Nature, 616(7955):199-206. 6. Zheng LM, Liu N*, Gao XY, Zhu WQ, Liu K, Wu C, Yan R, Zhang JC, Gao X, Yao YT, Deng B, Xu J, Lu Y, Liu, ZM, Li MS, Wei XD*, Wang HW*, Peng HL*. (2023) Uniform thin ice on ultraflat graphene for high-resolution cryo-EM. Nat Methods, 20(1):123-130. 7. Lu Y, Liu N*, Liu Y, Zheng LM, Yang JH, Wang J, Jia X, Zi QR, Peng HL*, Rao Y*, Wang HW*. (2022) Functionalized graphene grids with various charges for single-particle cryo-EM. Nat. Commun., 13(1):6718. 8. Su S, Wang J, Deng T, Yuan X, He J, Liu N, Li XM, Huang Y, Wang HW*, Ma JB*. (2022) Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607(7918):399-406. 9. Liu N, Zheng LM, Xu J, Wang J, Hu CX, Lan J, Zhang X, Zhang J, Xu K, Cheng H, Yang Z, Gao X, Wang X, Peng HL*, Chen YN*, Wang HW*. (2021) Reduced graphene oxide membrane as supporting film for high-resolution cryo-EM. Biophysics Reports, 7(3): 227-238. (Cover) 10. Jin W, Wang J, Liu CP, Wang HW*, Xu RM*. (2020) Structural Basis for pri-miRNA Recognition by Drosha. Mol. Cell, 78(3): 423-439. 11. Fan X, Wang J, Zhang X, Yang Z, Zhang JC, Zhao L, Peng HL, Lei J*, Wang HW*. (2019) Single particle cryo-EM reconstruction of 52 kDa streptavidin at 3.2 Angstrom resolution. Nat. Commun., 10(1):2386. 12. Liu N, Zhang J, Chen Y*, Liu C, Zhang X, Xu K, Wen J, Luo Z, Chen S, Gao P, Jia K, Liu Z, Peng H*, Wang HW*. (2019) Bioactive Functionalized Monolayer Graphene for High-Resolution Cryo-Electron Microscopy. J. Am. Chem. Soc., 141(9):4016-4025. 13. Wang J, Wang J, Hu M, Wu S, Qi J, Wang G, Han Z, Qi Y, Gao N, Wang HW*, Zhou JM*, Chai J*. (2019) Ligand-triggered allosteric ADP release primes a plant NLR complex. Science, 364(6435). pii: eaav5868. 14. Wang J, Hu M, Wang J, Qi J, Han Z, Wang G, Qi Y, Wang HW*, Zhou JM*, Chai J*. (2019) Reconstitution and structure of a plant NLR resistosome conferring immunity. Science, 364(6435). pii: eaav5870. 15. Liu Z, Wang J, Cheng H, Ke X, Sun L, Zhang Q, Wang HW*. (2018) Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate. Cell, 173(5):1191-1203.