张伟东 - 吉林大学

个人简介

主要科研工作经历 2018.11—目前吉林大学药学院，博士生导师 2017.07—目前加拿大纪念大学医学院，教授（客座） 2017.03—目前吉林大学药学院，副教授，硕士生导师 2016.12—2017.02 加拿大水文研究所，高级研究员 2013.10—2016.10 加拿大纪念大学医学院，博士后研究员 2012.10—2013.09 新加坡国立大学公共卫生学院，研究员 2009.07—2012.09 第四军医大学药学部，讲师 2006.09—2009.07 中国药科大学中药学院，博士 (专业方向：药剂学)

研究领域

1. 骨性关节炎形成机制及中药调控研究 2. 临床代谢组学及生物标志物研究 3. 基于新技术的中药药效物质基础及新药研究

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Zhang WD, Sun S, Aitken D, Likhodii S, Liu M, Martin G, Furey A, Randell E, Rahman P, Jones G, Zhai G. Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis. Rheumatology (Oxford), 2016;55:1566-74. 2. Zhang WD, Sun G, Likhodii S, Liu M, Aref-Eshghi E, Harper PE, Martin G, Furey A, Green R, Randell E, Rahman P, Zhai G. Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients. Osteoarthritis and Cartilage. 2016;24:827-34. 3. Zhang WD, Sun G, Likhodii S, Aref-Eshghi E, Harper PE, Randell E, Martin G, Zhai G. Metabolomic analysis of human synovial fluid and plasma reveals that phosphatidylcholine metabolism is associated with both osteoarthritis and diabetes. Metabolomics. 2016,12:4. 4. Zhang WD, Likhodii S, Aref-Eshghi E, Zhang Y, Harper PE, Randell E, Green R, Martin G, Furey A, Sun G, Rahman P, Zhai G. Relationship Between Blood Plasma and Synovial Fluid Metabolite Concentrations in Patients with Osteoarthritis. J Rheumatol. 2015;42:859-65. 5. Zhang WD, Randell EW, Sun G, Likhodii S, Liu M, Furey A, Zhai G. Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes. PLoS One. 2017; 12;12(9):e0184105. 6. Zhang WD, Likhodii S, Zhang Y, Aref-Eshghi E, Harper PE, Randell E, Green R, Martin G, Furey A, Sun G, Rahman P, Zhai G. Classification of osteoarthritis phenotypes by metabolomics analysis. BMJ Open. 2014; 4(11):e006286. 7. Zhang WD, Wang PY, Wang Y, Wang Q, Gu Y, Cao J, Wang SQ, Wang XJ. Simultaneous determination of aurantio-obtusin, chrysoobtusin, obtusin and 1-desmethylobtusin in rat plasma by UHPLC-MS/MS. Biomed Chromatogr. 2014, 28:369-74 8. Zhang WD, Wang Y, Wang Q, Yang WJ, Gu Y, Wang R, Song XM, Wang XJ. Quality evaluation of Semen Cassiae by using ultra high-performance liquid chromatography coupled with mass spectrometry. Journal of Separation Science. 2012; 35, 2054-2062. 9. Zhang WD, Wang Q, Wang Y, Wang XJ, Pu JX, GuYi, Wang R. Application of ultrahigh-performance LC coupled with MS for analysis of lignans and quality control of Fructus Schisandrae chinensis. Journal of Sepaaration Science. 2012;35, 2203-09. 10. Zhang WD, Yang WJ, Wang XJ, Gu Y, Wang R. Simultaneous determination of tectorigenin, irigenin and irisflorentinin rat plasma and urine by UHPLC-MS/MS: Application to pharmacokinetics. J ChromatogrB. 2011; 879, 3735-3741. 11. Zhang WD, Wang XJ, Zhou SY, Gu Y, Wang R, Zhang TL, Gan HQ. Determination of free and glucuronidated kaempferol in rat plasma by LC-MS/MS : Application to pharmacokinetic study. J ChromatogrB.2010; 878, 2137-214. 12. Zhang WD, Qi LW, Yang XL, Huang WZ, Li P, Yang ZL. Identification of the major metabolites of tectorigenin in rat bile by liquid chromatography combined with TOF and ion trap tandem mass spectrometry. Rapid commun in mass spectrom.2008; 22, 2677-84. 13. Zhang WD, Yang XL, Xu L, Cao J, Li P, Yang ZL. Identification of the key metabolites of tectorigenin in rat urine by LC-MSn. Biomed Chromatogr. 2009; 23, 219-221. 14. Zhang WD, Qi LW, Yang XL, Lu YW, Li P, Yang ZL. Determination of tectorigenin in rat plasma:Application to a pharmacokinetic study after oral administration of tectorigenin or its prodrug tectoridin. Chromatogr.2008；68，1021-1025. 15. Li ZM, Zhang YX, Hu T, Likhodii S, Sun G, Zhai G, Fan, ZZ, Xuan CJ, Zhang WD*(通讯). Differential metabolomics analysis allows characterization of diversity of metabolite networks between males and females. PLoS One. In press (2018). 16. Jason S, Zhang WD*, Shestopaloff K, Likhodi S, Sun G, Furey A, Randell ED, Sundararajan K, Gandhi R, Zhai G and Kapoor M. A classification modeling approach for determining metabolite signatures in osteoarthritis. PLoS One2018;13(6):e0199618.