个人简介

PhD - University of Alberta BSc - University of Alberta

研究领域

organic

Dr. Derksen's research is in the area of synthetic organic chemistry that is applied to the preparation of biologically active compounds. Natural products that interact with tubulin or with ion channels are of particular interest. This research program has a focus on addressing stereochemical challenges, minimizing the use of protecting groups, and minimizing the number of total steps through innovative development of synthetic methodology. At the completion of a synthesis, compounds are tested with the help of collaborators to gain insight into the interactions required for receptor binding or eliciting a biological response.

近期论文

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Gorobets, E.; Wong, N. E.; Paton, R. S.; Derksen, D. J.* Divergent Photocyclization/1,4-Sigmatropic Rearrangements for the Synthesis of Sesquiterpenoid Derivatives Org. Lett. 2017, 19, 484-487. doi: 10.1021/acs.orglett.6b03635 Lee, J.; Papatzimas, J. W.; Bromby, A. D.; Gorobets, E.; Derksen, D. J.* Thiaporphyrin-mediated Photocatalysis Using Red Light RSC Adv. 2016, 6, 59269-59272. doi: 10.1039/c6ra11374e LeGay, C. M.; Gorobets, E.; Iftinca, M.; Ramachandran, R.; Altier, C.; Derksen, D. J.* Natural-Product-Derived Transient Receptor Potential Melastatin 8 (TRPM8) Channel Modulators Org. Lett. 2016, 18, 2746-2749. doi: 10.1021/acs.orglett.6b01222 Gorobets, E.; Parvez, M.; Derksen, D. J.; Keay, B. A.* Generation of Benzyne Species from Diphenylphosphoryl Derivatives - Simultaneous Exchange of Three Functional Groups Chem. Eur. J. 2016, 22, 8479-8482. doi: 10.1002/chem.201601370 Kerr, R. G.*; Brophy, S.; Derksen, D. J.* Synthesis and Evaluation of Anti-inflammatory Activity of Derivatives of the Marine Natural Products Fuscol and Eunicol Bioorg. Med. Chem. Lett. 2014, 24, 4804-4806. doi: 10.1016/j.bmcl.2014.09.008 Harty, M.; Nagar, M.; Atkinson, L.; LeGay, C. M.; Derksen, D. J.* Bearne, S. L.* Inhibition of Serine and Proline Racemases by Substrate-Product Analogues Bioorg. Med. Chem. Lett. 2014, 24, 390-393. doi: 10.1016/j.bmcl.2013.10.061 Pustam, A.; Smith, C.; Deering, C.; Grosicki, K.; Leng, T.-Y.; Yang, J.; Lin, S.; Pink, D.; Gill, T.; Graham, L.; Derksen, D.; Bishop, C.; Demont, M.; Wyeth, R.; Smith-Palmer, T.* Interactions of Protamine with the Marine Bacterium, Pseudoalteromonas sp. NCIMB 2021. Lett. Appl. Microbiol. 2013, 58, 225-230. doi: 10.1111/lam.12177 LeGay, C. M.; Boudreau, C. G.; Derksen, D. J.* Elucidating Absolute Configuration of Unsaturated Alcoholsvia Enantioselective Acylation Reactions. Org. Biomol. Chem. 2013, 11, 3432-3435. doi: 10.1039/C3OB40709H Huang, Z.; Derksen, D. J.; Vederas, J. C. Preparation and Use of Cysteine Orthoesters for Solid-Supported Synthesis of Peptides. Org. Lett. 2010, 12, 2282-2285. doi: 10.1021/ol100645t Derksen, D. J.; Boudreau, M. A.; Vederas, J. C. The Role of Hydrophobic Interactions in the N-terminus of Leucocin A and Pediocin PA-1. Chembiochem, 2008, 9, 1898-1901. doi: 10.1002/cbic.200800272 van Belkum, M. J.; Derksen, D. J.; Franz, C. M. A. P.; Vederas, J. C. Structure Function Relationship of Inducer Peptide Pheromones Involved in Bacteriocin Production in Carnobacterium maltaromaticum andEnterococcus faecium. Microbiology, 2007, 153, 3660-3666. doi: 10.1099/mic.0.2007/009183-0 Pattabiraman, V. R.; Stymiest, J. L.; Derksen, D. J.; Martin, N. I.; Vederas, J. C. Multiple On-Resin Olefin Metathesis to Form Ring Expanded Analogues of the Lantibiotic Peptide, Lacticin 3147 A2. Org. Lett. 2007, 9, 699-702. doi: 10.1021/ol063133j Derksen, D. J.; Stymiest, J. L.; Vederas, J. C. Antimicrobial Leucocin Analogues with a Disulfide Bridge Replaced by a Carbocycle or by Noncovalent Interactions of Allyl Glycine Residues. J. Am. Chem. Soc. 2006, 128, 14252-14253. doi: 10.1021/ja066203q Gursky, L. J.; Martin, N. I.; Derksen, D. J.; van Belkum, M. J.; Kaur, K.; Vederas, J. C.; Stiles, M. E.; McMullen, L. M. Production of Piscicolin 126 by Carnobacterium maltaromaticum UAL26 is Controlled by Temperature and Induction Peptide Concentration. Arch. Microbiol. 2006, 186, 317-325. doi: 10.1007/s00203-006-0147-z Spantulescu, M. D.; Jain, R. P.; Derksen, D. J.; Vederas, J. C. Photolysis of Diacyl Peroxides: A Radical Based Approach for the Synthesis of Functionalized Amino Acids. Org. Lett. 2003, 5, 2963-2965. doi: 10.1021/ol035125y