个人简介

B.Sc. (Honours Chemistry), McGill University, 1968 Ph.D. (Chemistry), McGill University, 1974, with Prof. D.N. Harpp PDF, Imperial College, U.K. with Nobel Laureate Prof. Sir Derek H.R. Barton, 1974-76

研究领域

Dr. Back's teaching interests include all facets of organic chemistry, from introductory to graduate level courses, with an emphasis in organic synthesis.

The synthesis of biologically interesting target molecules, including steroidal enzyme inhibitors, azasteroids with anticancer activity, antibiotics such as the antiviral agent virantmycin and the antifungal agent Antibiotic A25822B, dendrobatid alkaloids, brassinolide and related plant growth-promoters and insect anti-feedants related to bakkenolide A. The design of novel analogues with custom-tailored properties by means of molecular modeling is also carried out in conjunction with synthetic studies. The development of new synthetic methodology based on reactions of organosulfur and selenium compounds, including coupling reactions of unsaturated sulfones, reductive desulfurizations with metal borides, free-radical reactions of selenium compounds and methods for enantioselective synthesis based on chirality transfer from sulfur and selenium to carbon.

近期论文

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A. Johnson, M.J. Saunders and T.G. Back, “Stereodivergent Synthesis of the LFA-1 Antagonist BIRT-377 by Porcine Liver Esterase Desymmetrization and Curtius Rearrangement” Org. Biomol. Chem. in press (2015). Y. Zhu and T.G. Back, “Preparation of 1,7- and 3,9-Dideazapurines from 2-Amino-3-iodo and 3-Amino-4-iodopyridines and Activated Acetylenes by Conjugate Addition and Copper-Catalyzed Intramolecular Arylation”, J. Org. Chem. 79, 11270-11276 (2014). T. Shinohara, D. Kim, B. Joung, M. Maruyama, K. Vembaiyan, T. G. Back, S. R. W. Chen, P.-S. Chen and S.-F. Lin, “Carvedilol Analog Modulates Both Basal and Stimulated Sinoatrial Node Automaticity” Heart & Vessels, 29, 396-403 (2014). D.J. Press, N.M.R. McNeil, M. Hambrook, and T.G. Back, “Effects of Methoxy Substituents on the Glutathione Peroxidase-like Activity of Cyclic Seleninate Esters”, J. Org. Chem. 79, 9394-9401 (2014). J. Zhang, C.D. Smith, Q. Zhou, J. Xiao, G. Wu, A. Nani, A., T.G. Back, M. Fill, S.R.W. Chen, “Suppression of Spontaneous Ca(2+) Release by Cardioprotective Drugs”, Biophys. J., 106, 109A, Supplement 1 (2014). J. Guo, S. Durdagi, M. Changalov, L. Perissinotti, J. Hargreaves, T.G. Back, H. Duff, and S. Noskov, “Structure Driven Design of Novel Human Ether-a-Go-Go-Related-Gene Channel hERG Activators”,PLoS One, 9, e105513, 1-14 (2014). Chris D. Smith, A. Wang, K. Vembaiyan, J. Zhang, C. Xie, Q. Zhou, G. Wu, S. R. W. Chen and T.G. Back, “Novel Carvedilol Analogs that Suppress Store Overload Induced Ca2+ Release” J. Med. Chem., 56, 8626−8655 (2013). N.M.R. McNeil, M.C. Matz and T.G. Back, A Fluxional Cyclic Seleninate Ester: NMR and Computational Studies, Glutathione Peroxidase-Like Behavior and an Unexpected Rearrangement”, J. Org. Chem., 78, 10369-10382 (2013). M. Sepulveda, L. Gonano, T.G. Back, S.R.W. Chen and M.V. Petroff, “Role of CaMKII and ROS in Rapid Pacing-Induced Apoptosis”, J. Mol. Cellular Cardiology, 63, 135-145 (2013). D. Gao and T. G. Back, “Synthesis of the Reverse Transcriptase Inhibitor L-737,126 and the CB2 Cannabinoid Receptor Agonist Pravadoline by a Copper-Catalyzed Intramolecular Cross-Coupling” Synlett 24, 389-393 (2013). M. Maruyama, J. Xiao, Q. Zhou, K. Vembaiyan, S.-K. Chua, M. Rubart von der Lohe, S.-F. Lin, T. G. Back, S. R. W. Chen and P.-S. Chen, “Carvedilol Analogue Inhibits Triggered Activities Evoked by Both Early and Delayed Afterdepolarizations”, Heart Rhythm, 10, 101-107 (2013). D. Gao and T. G. Back, “Indole Synthesis by Conjugate Addition of Anilines to Activated Acetylenes and an Unusual Ligand-Free Copper(II)-Mediated Intramolecular Cross-Coupling”, Chem. Eur. J., 18, 14828-14840 (2012). D. J. Press, N. M. R. McNeil, A. Rauk and T. G. Back, “NMR and Computational Studies of the Configurational Properties of Spirodioxyselenuranes. Are Dynamic Exchange Processes or Temperature-Dependent Chemical Shifts Involved?”, J. Org. Chem., 77, 9268–9276 (2012). E. A. Mercier, C. D. Smith, M. Parvez and T. G. Back, "Cyclic Seleninate Esters as Catalysts for the Oxidation of Sulfides to Sulfoxides, Epoxidation of Alkenes and Conversion of Enamines to α-Hydroxyketones", J. Org. Chem., 77, 3508–3517 (2012). D. J. Press, T. G. Back and T. C. Sutherland, “Charge Transfer Complexes of Electron-Rich Naphthalene peri-Dichalcogenides with TCNQ”, Tetrahedron Lett., 53, 1603-1605 (2012). L. V. Kurepin, S.-H. Joo, S.-K. Kim, R. P. Pharis and T. G. Back, “Interaction of Brassinosteroids with Light Quality and Plant Hormones in Regulating Shoot Growth of Young Sunflower and Arabidopsis Seedlings”, J. Plant Growth Regul., 31, 156-164 (2012). D. J. Press and T. G. Back, “Enhanced Glutathione Peroxidase Activity of Conformationally Restricted Naphthalene peri-Dichalcogenides”, Org. Lett., 13, 4104-4107 (2011). Q. Zhou, J. Xiao, D. Jiang, R. Wang, K. Vembaiyan, A. Wang, C.D. Smith, C. Xie, W. Chen, X. Tian, P. Jones, X. Zhong, A. Guo, D. Yang, J. Bolstad, X. Li, J. Chen, A.M. Gillis, H.J. Duff, H. Cheng, L.S. Song, T.G. Back and S.R.W. Chen, “Carvedilol and its Novel Non-Beta-Blocking Analogues Inhibit Spontaneous Ca+2 Release and Prevent Stress-Induced Ventricular Tachycardia”, Nature (Medicine),17, 1003-1010 (2011). D. Gao, M. Parvez and T.G. Back, “Synthesis of Indoles by Conjugate Addition and Ligand-Free Copper-Catalyzed Intramolecular Arylation of Activated Acetylenes with o-Haloanilines”, Chem. Eur. J., 16, 14281-14284 (2010). K.N. Clary and T.G. Back, “Synthesis of Onychine and Formal Synthesis of Eupolauridine via the Vinylogous aza-Morita-Baylis-Hillman Reaction”, Synlett, 2802-2804 (2010).