Johnson, Casonya - Georgia State University

个人简介

Ph.D. Biology Johns Hopkins University 1996 Molecular Genetics and Biochemistry Cellular, Molecular Biology and Physiology Neurobiology and Behavior Post-embryonic functions for bHLH Transcription Factors in Regulating Tissue Morphogenesis, Reproduction, and Fat/Iron Metabolism

研究领域

Our research focuses on understanding the mechanisms of transcriptional regulation, and how these mechanisms are used to control post-embryonic development and morphogenesis, animal behavior, and physiological responses to environmental stress. We use Caenorhabditis elegans to investigate the roles of an atypical bHLH protein family and a glia-specific bHLH protein in regulating gene expression and we seek to understand how these proteins control 1) reproduction and organ development, 2) nervous system function and development, and 3) fat storage and metabolism in larval and adult animals.

近期论文

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HES-Mediated Repression of Pten in Caenorhabditis elegans. Chou HT, Vazquez RG, Wang K, Campbell R, Milledge GZ, Walthall WW, Johnson CM. G3 (Bethesda). 2015 Oct 4;5(12):2619-28. doi: 10.1534/g3.115.019463. Dopamine signaling in C. elegans is mediated in part by HLH-17-dependent regulation of extracellular dopamine levels. Felton CM, Johnson CM. G3 (Bethesda). 2014 Apr 7;4(6):1081-9. doi: 10.1534/g3.114.010819. Genome-wide microarrray analysis reveals roles for the REF-1 family member HLH-29 in ferritin synthesis and peroxide stress response. Quach TK, Chou HT, Wang K, Milledge GZ, Johnson CM. PLoS One. 2013;8(3):e59719. doi: 10.1371/journal.pone.0059719. Epub 2013 Mar 22. HLH-29 regulates ovulation in C. elegans by targeting genes in the inositol triphosphate signaling pathway. White A, Fearon A, Johnson CM. Biol Open. 2012 Mar 15;1(3):261-8. doi: 10.1242/bio.2012046. Epub 2012 Feb 8. Modulation of dopamine-dependent behaviors by the Caenorhabditis elegans Olig homolog HLH-17. Felton CM, Johnson CM. J Neurosci Res. 2011 Oct;89(10):1627-36. doi: 10.1002/jnr.22694. Epub 2011 Jun 17. Molecular characterization of the Caenorhabditis elegans REF-1 family member, hlh-29/hlh-28. McMiller TL, Sims D, Lee T, Williams T, Johnson CM. Biochim Biophys Acta. 2007 Jan;1769(1):5-19. Epub 2006 Dec 29. Middle/high school students in the research laboratory: A summer internship program emphasizing the interdisciplinary nature of biology. McMiller T, Lee T, Saroop R, Green T, Johnson CM. Biochem Mol Biol Educ. 2006 Mar;34(2):88-93. doi: 10.1002/bmb.2006.49403402088. Molecular characterization of HLH-17, a C. elegans bHLH protein required for normal larval development. McMiller TL, Johnson CM. Gene. 2005 Aug 15;356:1-10.