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个人简介

赵勇,男,博士,研究员,博士生导师;中国科学院动物研究所副所长,中国科学院动物研究所膜生物学国家重点实验室主任,移植生物学研究组组长。 国家“杰出青年基金”获得者。于2003年8月为中科院“百人计划”国外引进杰出人才项目回国,建立移植生物学实验室,现有工作人员4人,博士后4人,博士/硕士生10余人。主要应用移植动物模型、基因工程改造动物及分子生物学技术,探讨T细胞移植免疫耐受及免疫应答调控的分子机制,建立移植免疫耐受的诱导方案,开发组织细胞工程产品及基因工程药物。此外,通过比较同种异种移植免疫排斥反应的异同,为寻找克服异种移植免疫排斥的有效途径提供指导。在NatureMedicine、NatureCommunications,Blood,J.Immunology、TrendsinImmunology、JournalofMolecularMedicine、Immunology、AmJofTranspl及Transplantation等国际刊物发表SCI学术文章130余篇,主编《异种移植免疫学》及《移植免疫耐受》。实验室目前得到科技部973项目、国家自然基金委重点项目及中科院创新方向性项目等资助。 实验室目前得到中国科学院“百人计划”、国家杰出青年基金、科技部973项目、国家自然基金委重点项目及中科院创新方向性项目等资助。实验室现已毕业博士/硕士研究生30余名。博士研究生毕业去向主要为在美国等出国留学,硕士研究生主要从事国家公务员、企业工作。 1993年7月在白求恩医科大学获生物学博士; 1993年8月-1995年3月日本东京三菱化成生命科学研究所任特别研究员; 1995年3月-2000年5月在哈佛大学/麻省总医院移植生物学研究中心博士后; 2000年5月起至2003年8月任美国内布拉斯加大学医学院,外科兼病理与微生物科助理教授; 2003年8月-,中科院动物所研究员,博士导师承担科研项目情况: 国家重点基础研究发展计划:胸腺与免疫细胞发育的分子调控 科技部重大专项:艾滋病病人的疾病进展相关因素的研究 杰出青年基金项目:移植免疫学 国家自然基金重点项目:混合嵌合体小鼠巨噬细胞免疫耐受特征及其分子机制研究 国家自然科学基金面上项目:TSC1对T细胞发育分化的免疫调节效应 国家基金委与广东省联合基金重点项目:凋亡细胞诱导移植免疫耐受的研究 中科院创新项目:胸腺上皮前体(干)细胞的特异标志筛选及鉴定

研究领域

研究领域: 主要从事同种/异种移植免疫排斥反应及T细胞免疫耐受的诱导及其分子机制、抑制性T细胞的诱导与应用、胸腺发育分化的分子调节、巨噬细胞生物学等免疫学领域的研究。

近期论文

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赵勇主编.2003.异种移植免疫学.中国医药科技出版社.中国:北京. 赵勇主编.2005.移植免疫耐受.中国医药科技出版社.中国:北京. SunL,SunC,LiangZ,LiH,ChenL,LuoH,ZhangH,DingP,SunX,QinZ*andZhaoY*FSP1+fibroblastsubpopulationisessentialforthemaintenanceandregenerationofthymicmedullaryzone.JournalofImmunology2014(revision) SunL,ZhangH,LuoH,LiangZ,DuJ,WuL,ZhangL,LuJ,andZhaoY*AcuteallograftrejectionsignificantlyimpairshostthymicmedullaryepithelialcellhomeostasisviaIL-17.AmericanJournalofTransplantation2014(revision) WangZ,ZhouS,SunC,LeiT,PengJ,LiW,DingP,LuJ,andZhaoY*IFN-γinhibitsnon-opsonizedphagocytosisofmacrophagesviaanmTORC1-c/EBPβpathway.JournalofInnateImmunology2014(revision). ZhuL,YangT,LiL,SunL,HouY,HuX,ZhangL,TianH,ZhaoQ,PengJ,ZhangH,WangR,YangZ,ZhangL,andZhaoY*TSC1controlsmacrophagepolarizationtopreventinflammatorydisorder.NatureCommunications2014(accepted) HouY,LinH,ZhuL,LiuZ,HuF,ShiJ,YangT,ShiX,GuoH,TanX,ZhangL,WangQ*,LiZ*,andZhaoY*IFN-γinhibitsTLRligands-inducedproteaseHTRA1expressioninrheumatoidarthritis.JournalofImmunology2014(online). DengX,ZhangF,WangL,RuiW,LongF,ZhaoY*,ChenD,DingW*Airbornefineparticulatematterinducesmultiplecelldeathpathwaysinhumanlungepithelialcells.Apoptosis201419(7):1099-112. Chen,H,Yang,T,Zhu,L.,ZhaoY*CellularMetabolismonT-CellDevelopmentandFunction.InternationalReviewofImmunology.2014(online) ShenX,DuJ,GuanW,andZhaoY*ThebalanceofintestinalFoxp3+regulatoryTcellsandTh17cellsanditsbiologicalsignificance.ExpertReviewofClinicalImmunology201410(3):353-362. XiaoW,MengG,ZhaoY,ChangZ,LiT,SunC,LiZ,ZhaoY,LuoM,ZhengX*HumansecretedproteinSI-CLPaggravatestheinflammationofrheumatoidarthritisandisapotentialmacrophageinflammatoryregulatorArthritis&Rheumatism201466(5):1141-1152. SunL,LiH,LuoH,andZhaoY*Thymicepithelialcelldevelopmentanditsdysfunctioninhumandiseases.BioMedResearchInternational2014:206929 LuoH,WangC,FengM,ZhaoY*.MicrogravityinhibitsrestingTcellimmunityinanexposuretime-dependentmanner.InternationalJournalofMedicalSciences201411(1):87-96. WangC,LuoH,ZhuL,YangF,ChuZ,TianH,FengM,ShangP*,ZhaoY*Microgravityinhibitionoflipopolysaccharide-inducedTNF-αexpressioninmacrophagecells.InflammationResearch201463(1):91-98. SunB,HuX,LiuG,MaB,XuY,YangT,ShiJ,YangF,LiH,ZhangL*,andZhaoY*PhosphataseWip1negativelyregulatesneutrophilantimicrobialimmunity.JournalofImmunology2014192(3):1184-1195. SunL,LiH,LuoH,ZhangL,HuX,YangT,SunC,ChenH,ZhangLandZhaoY*.PhosphataseWip1isessentialforthematurationandhomeostasisofmedullarythymicepithelialcellsinmiceJournalofImmunology2013191(6):3210-3220. ChenH,ZhangLJ,ZhangHB,LiL,XiaoY,SunLN,LiH,CorleyD,LiuG,YangZZ*,andZhaoY*TSC1/2complexnegativelyregulatesthymicCD4+CD25+Foxp3+Tregdevelopmentinmice.FASEBJ201327(10):3979-3990. HouY,LinH,DuanK,ZhuL,LiuZ,HuF,ShiJ,RaoE,YangT,ShiX,YinZ,ZhuM,ZhangL,GodleyF.B.,WangQ*,LiZ*,andZhaoY*LPSincreasestheincidenceofcollagen-inducedarthritisinmicethroughinductionofproteaseHTRA1expressionArthritis&Rheumatism201365(11):2835-2846. LiuG,HuX,SunB,ShiJ,ZhangL*,andZhaoY.*PhosphataseWip1negativelyregulatesneutrophildevelopmentthroughp38MAPK-STAT1.Blood2013121(3):519-529. SunLN,LiHR,LuoHY,andZhaoY.*Thymicepithelialcelldevelopmentanddifferentiation:Cellularandmolecularregulations.ProteinCell20134(5):342-355. WuT,SunC,ChenZ,ZhenY,PengJ,QiZ.,YangX.,andZhaoY*Smad3-deficientCD11b+Gr1+myeloid-derivedsuppressorcellspreventallograftrejectionviathenitricoxidepathwayJournalofImmunology2012189(10):4989-5000. GeQ.andZhaoY.EvolutionofthymusorganogenesisDevCompImmunol201339(1-2):85-90. HuX,LiuG,HouY,ShiJ,ZhuL,JinD,PengJ,andZhaoY*InductionofrecipientM2macrophagesbyallogeneicdonorregulatoryCD4+CD25+TcellsinmiceCellMolImmunol20129(6):464-472. SunC.,JiangY.,SunL.,ShangH.*,andZhaoY.*ThecharacteristicsofTh1/Th2cytokinereceptorsonmonocytesinuntreatedpatientsoflongtermnonprogressororchronicHIVinfection.CurrentMoleculeMedicine.201212(8):1028-1039. Wu,T.,Zhang,L.,Xu,K.,Sun,C.,Lei,T.,Peng,J.,Liu,G.,Wang,R.,ZhaoY*,ImmunosuppressivedrugsoninducingAg-specificCD4+CD25+Foxp3+Tregcellsduringimmuneresponseinvivo.TransplantImmunology,2012,27(1):30-38 Huang,L.,Wang,Z.B.Jiang,Z.Z.Hu,M.W.Lin,F.,Zhang,Q.H.,Luo,Y.B.,Hou,Y.,Zhao,Y.,Fan,H.Y.,Schatten,H.SpecificdisruptionofTsc1inovariangranulosacellspromotesovulationandcausesprogressiveaccumulationofcorporalutea.PLoSOne2012,8(1):e54052. Sun,Q.Y.Liu,X.,Ma,B.,Malik,A.B.,Tang,H.,Yang,T.,Sun,B.,Wang,G.,Minshall,R.D.,Li,Y.,Zhao,Y.,Ye,R.D.,andXu,J.*Bidirectionalregulationofneutrophilmigrationbymitogen-activatedproteinkinasesNatureImmunology2012,13(5):457-464. Y.ZhangL,LiL,XiaoY,RaoE,MiaoZ,ChenH,SunL,LiH,ZhangHandZhaoY*TSC1/2pathwaycriticallyregulatesperipheralna?veCD8+TcellsurvivalandhomeostasisinmicePLoSOne2012,7(2):e30592. Jin,D.,Duan,K.,Zhang,L.,Peng,J.,andZhao,Y.*TheeffectsofleflunomideonCD4+CD25+Foxp3+Tregulatorycellsinmicereceivingallogeneicbonemarrowtransplantation.InflammationResearch2012,61(1):53-60. ZengC,ShiX,ZhangB,LiuH,ZhangL,DingW,andZhaoY*TheimbalanceofTh17/Th1/Tregsinpatientswithtype2diabetes:Relationshipwithmetabolicfactorsandcomplications.JMolecularMedicine2012,90(2):175-186. Zhen,Y.,Sun,L.,Liu,H.,Duan,K.,Zeng,C.,Zhang,L.,Jin,D.,Peng,J.,Ding,W.*,andZhao,Y.*AlterationsofperipheralCD4+CD25+Foxp3+TregulatorycellsinmicewithSTZ-induceddiabetes.CellMolImmunol2012,9(1):75-85. SunC,SunL,MaH,PengJ,ZhenY,DuanK,LiuG,DingW*andZhaoY.*ThephenotypeandfunctionalalterationsofmacrophagesinmicewithhyperglycemiaforlongtermJofCellPhysiology2012,227(4):1670-1679. DuanK,ZhangB,ZhangW,ZhaoY,QuY,SunC,andZhaoY*EfficientperipheralconstructionoffunctionalhumanregulatoryCD4+CD25highFoxp3+TcellsinNOD/SCIDmicegraftedwithfetalhumanthymus/livertissuesandCD34+cellsTransplImmunol2011,25(4):173-179. LiuG,DuanK,MaH,NiuZ,PengJ,andZhaoY*AninstructiveroleofdonormacrophagesinmixedchimerasintheinductionofCD4+Foxp3+Tregcells.ImmunologyandCellBiology2011,89(8):827-835. LaiL*,CuiC,JinJ,HaoZ,ZhengQ,YingM,BoydR,andZhaoYMouseembryonicstemcell-derivedthymicepithelialcellprogenitorsenhanceT-cellreconstitutionafterallogeneicbonemarrowtransplantationBlood2011;118(12):3410-3418 JaveedA,HouY,DuanK,ZhangB,ShenH,CaoY,ZhaoY*.Aspirinsignificantlydecreasesthenonopsonicphagocytosisandimmunogenicityofmacrophagesinmice.InflammationResearch,2011,60(4):389-398. LiuG,MaH,QiuL,LiL,CaoY,MaJ,ZhaoY*.PhenotypicandfunctionalswitchofmacrophagesinducedbyregulatoryCD4(+)CD25(+)Tcellsinmice.ImmunologyandCellBiology.2011,89(1):130-42. ZhuS,PeigneurS,GaoB,LuoL,JinD,ZhaoY,Tytgat.JMolecularDiversityandFunctionalEvolutionofScorpionPotassiumChannelToxins.Molecular&CellularProteomics2011;10(2):M110.002832 LiuG,ZhangLandZhaoY*.ModulationofimmuneresponsesthroughdirectactivationofToll-likereceptorstoTcells.ClinicalandExperimentalImmunology,2010,160:168-175. QuY,ZhangB,LiuS,ZhangA,WuT,ZhaoY*.2-Gywhole-bodyirradiationsignificantlyaltersthebalanceofCD4+CD25-TeffectorcellsandCD4(+)CD25(+)Foxp3(+)Tregulatorycellsinmice.Cellular&MolecularImmunology.2010,7(6):419-427. SunY,ZhuZ,LangnasAN,GrantWJ,BothaJF,ZhaoY,SudanDL,MercerDF.Plasmanitriteandnitratelevelsasanoninvasivemarkerofpathologyafterhumansmallboweltransplantation.Transplantation.2010,89(3):307-311. SunL,GuoJ,BrownR,AmagaiT,ZhaoY,SuDM.Decliningexpressionofasingleepithelialcell-autonomousgeneacceleratesage-relatedthymicinvolution.AgingCell2010,9(3):347-357. ZhaoY*andLiX*.Cross-immunetolerance:conceptionanditspotentialsignificanceontransplantationtolerance.Cellular&MolecularImmunology2010,7(1):20-25. LiangH,YangL,MaTandZhaoY*.Functionalexpressionofcysticfibrosistransmembraneconductanceregulationinmousechondrocytes.ClinicalandExperimentalPharmacology&Physiology.2010,37:506-508. QuYY,ZhangAJ,ZhangBJ,WangJJandZhaoY.*.Gamma-RayResistanceofRegulatoryCD4+CD25+Foxp3+TCellsinmice.RadiationResearch2010,173(2):148-157. JiangP,RaoEY,MengN,ZhaoY,WangJJ:MicroRNA-17-92significantlyenhancesradioresistanceinhumanmantlecelllymphomacells.RadiationOncology2010,5:100. ZhangY,WangJ,LiuF,YouZ,YangR,ZhaoY:EGFRinhibitorC225increasestheradiosensitivityofhumanlungsquamouscancercells.CancerCellInternational2010,10:39. YouZY,ZhaoY,LiuF,ZhangYD,WangJJ:TheradiosensitizationeffectsofEndostaronhumanlungsquamouscancercellsH-520.CancerCellInternational2010,10:17. WangJ,LiaoA,ZhuangH,ZhaoY:Thedirectbiologiceffectsofradioactive125IseedsonpancreaticcancercellsPANC-1,atcontinuouslow-doserates.CancerBiotherRadiopharm2009,24(4):409-416. ZhuangHQ,WangJJ,LiaoAY,WangJD,ZhaoY:Thebiologicaleffectof125IseedcontinuouslowdoserateirradiationinCL187cells.JExpClinCancerRes2009,28:12. LiaoA,WangJ,ZhuangH,ZhaoY.Relativebiologicaleffectivenessandcell-killingefficacyofcontinuouslow-dose-rate125Iseedsonprostatecarcinomacellsinvitro.IntegrCancerTher2010,9:59-65. ZhengQ,XuY,LiuY,ZhangB,LiX,GuoF,andZhaoY.*.InductionofFoxp3demethylationincreasesregulatoryCD4+CD25+Tcellsandpreventstheoccurrenceofdiabetesinmice.JournalofMolecularMedicine2009,87:1191-1205. DingC,TianP,JiaL,LiY,DingX,XiangH,XueW,ZhaoY.ThesynergisticeffectsofC.SinensiswithCsAinpreventingallograftrejection.FrontiersinBioscience2009,14:3864-3871. HuangY,WalstromA,ZhangL,ZhaoY,CuiM,YeLandZhengJ.TypeIinterferonsandinterferonregulatoryfactorsregulateTNF-relatedapoptosis-inducingligand(TRAIL)inHIV-1-infectedmacrophages.2009,PLoSONE4(4):e5397-1-14.doi:10.1371/journal.pone.0005397. JaveedA.,ZhangB.,QuY.,ZhangA.,SunC.,ZhangL.,LiuJ.,ZengC.,andZhaoY.*.ThesignificantlyenhancedfrequencyoffunctionalCD4+CD25+Foxp3+Tregulatorycellsintherapeuticdoseaspirin-treatedmice.TransplantImmunology2009,20:253-260. ZhangB.,ZhangA.,QuY.,LiuJ.,NiuZ.,andZhaoY.*.DevelopmentofmouseCD4+CD25+Foxp3+regulatoryTcellsinxenogeneicpigthymicgrafts.TransplantImmunology2009,20:180-185. ZhangB,DuanZandZhaoY.*.Mousemodelswithhumanimmunityandtheirapplicationinbiomedicalresearch.JournalofCellularandMolecularMedicine2009,13(6):1043-1058. ZhenY.,ZhengJ.,andZhaoY.*.RegulatoryCD4+CD25+Tcellsandmacrophages:communicationbetweentworegulatorsofeffectorTcells.InflammationResearch2008,57:564-570. ZhangB.,SunC.,QuY.,ZhangA.,LiuJ.,ZhangL.,NiuZ.,andZhaoY.*.DeficiencyofmouseCD4+CD25+Foxp3+regulatoryTcellsinxenogeneicpigthymus-graftednudemicesufferingfromautoimmunediseases.Cellular&MolecularImmunology2008,5:325-32 WangN,ZhangJS,ZhengQH,ZhaoY.*TheuniquelocalizationofZFP185aturopodofmouseTlymphocytesScandinavianJournalofImmunology2008,67(4):340-344. YiHF,ZhangJL,andZhaoY.*TheeffectsofantibodytreatmentonregulatoryCD4+CD25+TcellsTransplantImmunology2008,19(1):37-44. YiH,ZhenY,ZengC,ZhangLJ,andZhaoY.*.Depletinganti-CD4monoclonalantibody(GK1.5)treatment:influenceonregulatoryCD4+CD25+Foxp3+Tcellsinmice.Transplantation2008,85(8):1167-1174. MaHX,LiuGW,DingWJ,WuY,CaiL,andZhaoY.*.Diabetes-inducedimmunodeficiencyofF4/80+macrophages:astudyinstreptozotocin-inducedtype1diabeticmice.JournalofMolecularMedicine2008,86(4):391-400. CuiM,HuangYL,ZhaoY.*,andZhengJL*.TranscriptionfactorFoxO3amediatescellapoptosisinHIV-1infectedmacrophages.JournalofImmunology2008,180(2):898-906. JaveedA.andZhaoY.*.TheeffectsofimmunosuppressiononregulatoryCD4(+)CD25(+)Tcells:impactonimmunosuppressionselectionintransplantation.MolecularDiagnosisandTherapy2008,12:171-181. JinD.,ZhangL.,ZhengJ.,andZhaoY.*.TheinflammatoryTh17subsetinimmunityagainstselfandnon-selfantigens.Autoimmunity2008,41:154-162. JaveedA.,andZhaoY.*.MacrophageMigrationInhibitoryFactor:Roleininflammatorydiseasesandgraftrejection.InflammationResearch2007,57(2):45-50. ZhaoY.*andLiXC.Transplanttolerance:isitreallyfreeofconcerns?TrendsinImmunology2007,28(9):376-377. WangN,ZhangJS,ZhengQH,ZhaoY.*.Molecularcloningandcharacterizationofanovelmouseactin-bindingproteinZFP185.JournalofMolecularHistology2008,39(3):295-302. SunLN,andZhaoY*.Thebiologicalroleofdectin-1inimmuneresponseInternationalReviewsofImmunology2007,26:349-364. Kawahara,T,Rodriguez-Barbosa,J-I,ZhaoY.,Zhao,G,andSykes,M.Globalunresponsivenessasamechanismofnaturalkillercelltoleranceinmixedxenogeneicchimeras.AmericanJournalofTransplantation2007,7(9):2090-2097. ZhangAJ,QuY,ZhangB,ZhangLJ,ZengC,PengJX,JiXB,HouM,ZhaoY.*.ThedifferenteffectsofindirubinoneffectorandCD4+CD25+regulatoryTcellsinmice:potentialimplicationforthetreatmentofautoimmunediseases.JournalofMolecularMedicine2007,85:1263-1270. ZhangBJ,ZhangAJandZhaoY.*.Plateletaggregationandthrombosisinxenotransplantationbetweenpigsandhumans.ThrombosisResearch2008,121:433-441. QuYY.andZhaoY.*.RegulatoryCD4+CD25+Tcellscontrolledbymultiplepathwaysinmultiplelevels.InternationalReviewofImmunology200726(3):145-160. ZhaoY.*.ThedifferenteffectsofcyclosporinAandrapamycinonregulatoryCD4+CD25+Tcells:potentialrelationshipwithtransplanttoleranceinduction.ExpertReviewofClinicalImmunology2007,3(3):254-259. LiuGW,MaHX,JiangLL,PengJX,andZhaoY.*.TheimmunityofsplenicandperitonealF4/80+residentmacrophagesinmousemixedallogeneicchimeras.JournalofMolecularMedicine2007,85:1125-1135. YiH,ZhaoY.*.Chemokines,chemokinereceptorsandCD4+CD25+regulatoryTcells.ExpertReviewofClinicalImmunology2007,3(3):343-349. YiH,ZhangL,ZhenY,HeX,andZhaoY*.DendriticcellsinducedinthepresenceofGM-CSFandIL-5.Cytokine2007,37(1):35-43. ZhengQHandZhaoY.*.Thediversebio-functionsofLIMdomainproteins:determinedbysub-cellularlocalizationandprotein-proteininteraction.BiologyoftheCell2007,99(9):489-502. LiuGW,andZhaoY.*.Toll-likereceptorsandimmuneregulation:theirdirectandindirectmodulationonregulatoryCD4+CD25+Tcells.Immunology2007,122:149-156. WuTH,ZhenY,ZengC,andZhaoY.*.BandTlymphocyteattenuatorinteractswithCD3ζandinhibitsTyrosinephosphorylationofTCRζcomplexduringTcellactivation.ImmunologyandCellBiology2007,85:590-595. LiuGW,Ma,HX,JiangLL,andZhaoY.*.Allograftinflammatoryfactor-1anditsimmuneregulation.Autoimmunity2007,40(2):95-102. ZhangLJ,andZhaoY.*.TheregulationofFoxp3expressioninregulatoryCD4+CD25+Tcells:multiplepathwaysontheroad.JournalofCellularPhysiology2007,211(3):590-597. ZhaoL,WangHJ,SunLG,MaHX,LiuGWandZhaoY.*.ChangesofCD4+CD25+Foxp3+regulatoryTcellsinagedBalb/cmice.JournalofLeukocyteBiology2007,81(6):1386-1394. ZhangL,SunL,ZhaoY.*.Thymicepithelialprogenitorcellsandthymusregeneration:anupdate.CellResearch2007,17:50-55. ZengC,YZhen,SShu,TWu,HYi,ZLian,andZhaoY.*.TheinfluenceofcyclosporinAonlymphocyteattenuatorexpression.JournalofAutoimmunity2007,28(4):234-44. QuY;ZhangB;ZhaoL;LiuG;MaH;ERao;CZeng;andZhaoY.*.TheeffectofimmunosuppressivedrugrapamycinonregulatoryCD4+CD25+Foxp3+Tcellsinmice.TransplantImmunology2007,17:153-161. ZhaoY.*,SunY,NiuZQ,LiQH,PengJX,WangJJ,andLangnasA.Anovelapproachtogeneratehostanti-tumorTcells:AdoptiveimmunotherapybyTcellsmaturinginxenogeneicthymus.JournalofImmunotherapy2007,30(1):83-88. LiuGW,MaHX,ZhaoY.WuY,andZhaoY.*.Thenonopsonicallogeneiccellphagocytosisofmacrophagesdetectedbyflowcytometryandtwophotonfluorescencemicroscope.TransplantImmunology2006,16:220-226. LiuGW,XiaXP,GongSLandZhaoY.*.Themacrophageheterogeneity:differencebetweenmouseperitonealexudatesandsplenicF4/80+macrophages.JournalofCellularPhysiology2006,209:341-352. ZhaoY.*andLiuGW.Specificimmunetoleranceofantigen-presentingcells:Hypothesisandsignificance.MedicalHypotheses2007,68:404-406. ZhangBJ,GeB,XiaX,LiuJ,SunLG,RaoEY,andZhaoY.*.CompatibilitybetweenPorcineandHumanIL-2:Implicationforxenotransplantation.Xenotransplantation2006,13:423-432. WangHJ,ZhaoL,SunZY,SunLG,andZhaoY.*.ApotentialsideeffectsofCyclosporinA:itsinhibitiononCD4+CD25+regulatoryTcellsinmice.Transplantation2006,82(11):1484-1492. Zhao,Y.*.Thetwosimultaneouslyoccurringprocessesinoneimmuneresponse:Thepositiveimmunereactionandimmunetolerance.MedicalHypotheses2006,67(6):1384-1385. SunZY,WangHJ,SunLG,ZhaoL,YiHF,LiQH,PengJX,andZhaoY.*.PresenceoffunctionalmouseregulatoryCD4+CD25+Tcellsinxenogeneicneonatalporcinethymus-graftedathymicmice.AmericanJournalofTransplantation2006,6(12):2841-2850. SunYM,YangZ,NiuZ,LiQ,PengJ,LangnasAN.,MaM.Y.,andZhaoY.*.MOP3,acomponentofthemolecularclock,regulatesthedevelopmentofBcells.Immunology2006,119(4):451-460. SunYM,YangZ,NiuZ,LiQ,PengJ,WangW,MaM.Y.andZhaoY.*.ThemortalityofMOP3deficientmicewithasystemicfunctionalfailure.JournalofBiomedicalScience2006,13:845-851. LiuGW,WuGL,WuY,andZhaoY.*.Phagocytosisofapoptoticcellsandimmuneregulation.ScandinavianJournalofImmunology2006,64(1):1-9. ZhangLJ,YiHF,XiaXP,andZhaoY.*.Transforminggrowthfactor-b:animportantroleinCD4+CD25+regulatoryTcellsandimmunetolerance.Autoimmunity2006,39(4):269-276. LiuGW,WuY,GongSL,andZhaoY.*.Toll-likereceptorsandgraftrejection.TransplantImmunology2006,16:25-31. YiH.,ZhenY.,JiangL.,ZhengJ.,andZhaoY.*.ThephenotypiccharacterizationofnaturallyoccurringregulatoryCD4+CD25+Tcells.Cellular&MolecularImmunology2006,3(3):189-195. SunYM,GeBS,KasaiM,DiffendafferC,ParksN,LiH,PengJX,LangnasA,andZhaoY.*.InductionofregulatoryTcellsfrommatureTcellsbyallogeneicthymicepithelialcellsinvitro.TransplantInternational2006,19(5):404-414. WuTH,YangRL,XieLP,WangHZ,ChenLi,ZhangSY,ZhaoY.andZhangRQ.InhibitionofcellgrowthandinductionofG1-phasecellcyclearrestinhepatomacellsbysteroidextractfromMeretix.CancerLetters2006,232(2):199-205. ZengC,WuT,ZhenY,XiaXP,ZhaoY.*.BTLA,anewinhibitoryB7familyreceptorwithaTNFRfamilyligand.Cellular&MolecularImmunology2005,2(6):427-432. ZhangJL,CaiJ,WallsS,JacksonJD,KuszynskiCA,ZhaoY.,PawliukR,LeboulchP,FoxIJ.Tolerancebyselectiveinvivoexpansionofforeignmajorhistocompatibilitycomplex-transducedautologousbonemarrow.Transplantation2005,80(3):362-369. HuangY,ErdmanN,PengH,ZhaoY.andZhengJL.TheRoleofTNFRelatedApoptosis-InducingLigandinNeurodegenerativeDiseases.Cellular&MolecularImmunology2005,2(2):113-122. SunZY,FuJY,SunLG,LiuSC,ZhaoY.andGongSL.InhibitoryEffectonTumorGrowthofTumor-AssociatedAntigenPeptidesfromMurineHepatocarcinomaH-22.U.S.ChineseJournalofLymphologyandOncology2005,4(1):11-15. SunY.M.,LiH.,LangnasA.N.andZhaoY..Alteredallogeneicimmuneresponsesinmiddle-agedmice.Cellular&MolecularImmunology2004,1(6):440-446. XiongW.F.,ZhaoY.,PrallA.K.,GreinerT.C.,andBaxter,B.T.KeyrolesofCD4+andInterferon-γinthedevelopmentofabdominalaorticaneurysmsinamurinemodel.JournalofImmunology2004,172:2607-2612. ZhaoY.*,SunY,SunY.M.,andLangnasA.N.Achievementofcellularimmunityanddiscordantxenogeneictoleranceinmicebyporcinethymusgrafts(review).Cellular&MolecularImmunology2004,1(3):173-179. SunY.M.,LangnasA.N.,andZhaoY.*.TheinteractiondefectofaccessorymoleculesisresponsibleforthepoorexvivoxenogeneicresponsetohumanantigensofmouseThelpercells.ScandinavianJournalofImmunology2003,58:59-66. SykesM.,GarrigueV.,JohsonR.P.,NikolicB.,Rodriguez-BarbosaJ.I.,RosenzweigM.,SachsD.H.,WuA.,YamadaK.,andZhaoY.*.XenogeneicthymicreplacementtoachieveimmunerestorationinHIVinfection.ClinicalandAppliedImmunologyReviews2003,3:167-171. ZhaoY.,Rodriguez-BarbosaJ.I.,ShimizuA.,SwensonK.,SachsD.H.,andSykesM.Despiteefficientintrathymicnegativeselectionofhost-reactiveTcells,autoimmunediseasemaydevelopinporcinethymus-graftedathymicmice:Evidenceforfailureofregulatorymechanismssuppressingautoimmunity.Transplantation2003,75:1832-1840. ZhaoY.,OhdanH.,ManilayJ.O.,andSykesM.NKcelltoleranceinmixedallogeneicchimeras.JournalofImmunology2003,170:5398-5405. YangT.Y.,YMSun,LangnasA.N.,andZhaoY.*.Prolongationofallogeneicskingraftsurvivalbyinjectionofanti-Ly49AmAb,YE1/48.ClinicalImmunology2003,106:148-154. ZhaoY.*,XiongW.F.,YangT.Y.,PrallA.,BaxterB.T.,andLangnasA.N.XenogeneicratskingraftrejectioninM-CSF/macrophagedeficientmice.Xenotransplantation2003,10:232-239. BeschornerW.E.,ShearonC.C.,YangT.,LangnasA.N.,ThompsonS.C.,ZhaoY.,FrancoK.L.,RadioS.J.,andSudanD.L.Pre-transplantanalysisofaccommodationindonorpigs.Xenotransplantation2003,10(1):66-71. Rodriguez-BarbosaJ.I.,ZhaoY.,HouserS.,ZhaoG.,SachsD.H.,andSykesM.Fetalporcinethymusengraftment,survivalandCD4reconstitutioninaGalKOmiceisimpairedinthepresenceofhighlevelsofantibodiesagainstaGal.Xenotransplantation2003,10(1):24-40. Rodriguez-BarbosaJ.I.,ZhaoY.,EzquerraA.,ZhaoG.,SachsD.H.,andSykesM.MurineCD4TcellsselectedinahighlydisparatexenogeneicporcinethymusgraftdonotshowrapiddecayintheabsenceofselectingMHCintheperiphery.JournalofImmunology2002,169:6697-6710. LongoG.M.,XiongW.,GreinerT.C.,ZhaoY.,FiottiN.,andBaxterB.T.Matrixmetalloproteinase2and9workinconcerttoproduceaorticaneurysms.JournalofClinicalInvestigation2002,110(5):625-632. 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学术兼职

现为国际移植学会、美国免疫学会会员,中国生物工程学会、中国免疫学会理事,中国免疫学会移植免疫分会副主任委员,动物学杂志副主编,ExpertReviewofClinicalImmunology、Cellular&MolecularImmunologyEditor。

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