当前位置: X-MOL首页全球导师 国内导师 › 崔隽

个人简介

崔隽,博士,中山大学教授、博士生导师,生命科学学院副院长,生物化学系主任,广东省免疫学会常务理事,中国免疫学会终身会员。曾获2011年全国百篇优秀博士论文提名奖,并获2013年广东省自然科学杰出青年基金项目资助,2014年入选“广东省特支计划”青年工程拔尖人才,2015年入选国家自然科学基金优秀青年基金项目,并入选广东省高等学校优秀青年教师培养计划。主要研究方向为固有免疫系统识别和调控、信号转导机制与疾病相关性,以及系统生物学研究。在实验生物学(特别是分子免疫学)和计算生物学(生物信号传导网络的数学模型建立)领域均取得多项进展,目前已发表学术论文60余篇,在Cell, Immunity (2篇), Nature Immunology,Nature Communications,Science Advances(3篇),Advanced Science(2篇),JACI(2篇),Cell Research(4篇),EMBO J(3篇),EMBO Reports,Autophagy(5篇),Journal of Cell Biology,Cell Reports(3篇),Molecular Cell(3篇)等顶级杂志发表多篇一作或通讯作者论文,并撰写书目章节4篇, 主编专著一部(Autophagy Regulation of Innate Immunity, Springer-Nature 2020), 论文影响因子累计600以上,他引累计已达2000余次。

研究领域

主要研究方向为固有免疫系统识别和调控、信号转导机制与疾病相关性,以及系统生物学研究 具体的研究领域包括: 炎症反应 抗病毒免疫 细胞自噬 可逆泛素化及类泛素化修饰 肿瘤免疫 自身免疫性疾病 细胞信号网络的数学模拟和分析

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Wu Y#, Ma L#, Zhuang Z#, Cai S#, Zhao Z, Zhou L, Zhang J, Wang PH, Zhao J*, Cui J*. Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling. Signal Transduct Target Ther. 2020 Oct 6;5(1):221. doi: 10.1038/s41392-020-00332-2. PMID: 33024073 Free PMC article. Zhou L#, Liu T#, Huang B#, Luo M, Chen Z, Zhao Z, Wang J, Leung D, Yang X, Chan KW, Liu Y, Xiong L, Chen P, Wang H, Ye L, Liang H, Masters SL, Lew AM, Gong S, Bai F, Yang J, Pui-Wah Lee P, Yang W, Zhang Y, Lau YL*, Geng L*, Zhang Y*, Cui J*. Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development. J Allergy Clin Immunol. 2020 Sep 14:S0091-6749(20)31246-X. doi: 10.1016/j.jaci.2020.09.003. Online ahead of print. PMID: 32941940 Wu Y#, Jin S, Liu Q, Zhang Y, Ma L, Zhao Z, Yang S, Li YP, Cui J*. Selective autophagy controls the stability of transcription factor IRF3 to balance type I interferon production and immune suppression. Autophagy. 2020 May 31:1-14. doi: 10.1080/15548627.2020.1761653. Tian S#, Jin S#, Wu Y#, Liu T, Luo M, Ou J, Xie W, Cui J*. High-throughput screening of functional deubiquitinating enzymes in autophagy. Autophagy. 2020 May 26:1-12. doi: 10.1080/15548627.2020.1761652. Xie W#, Jin S#, Wu Y, Xian H, Tian S, Liu DA, Guo Z, Cui J*. Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34. Cell Rep. 2020 Feb 25;30(8):2807-2819.e4. doi: 10.1016/j.celrep.2020.01.088 Zhou J#, Sun T, Jin S, Guo Z, Cui J*. Dual Feedforward Loops Modulate Type I Interferon Responses and Induce Selective Gene Expression during TLR4 Activation. iScience. 2020 Feb 21;23(2):100881. doi: 10.1016/j.isci.2020.100881. Chen M#, Zhao Z#, Meng Q#, Liang P#, Su Z, Wu Y, Huang J, Cui J*.TRIM14 Promotes Noncanonical NF-kB Activation by Modulating p100/p52 Stability via Selective Autophagy. Advanced Science. 2019 Nov 11; DOI: 10.1002/advs.201901261 Zhang CX#, Ye SB#, Ni JJ#, Cai TT, Liu YN, Huang DJ, Mai HQ, Chen QY, He J, Zhang XS, Zeng YX*, Li J*, Cui J*. STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion. Cell Death Differ. 2019 Feb 28. doi: 10.1038/s41418-019-0302-0. Xian H#, Yang S#, Jin S#*, Zhang Y, Cui J*. LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I. Autophagy. 2019 May 22:1-11. doi: 10.1080/15548627.2019.1615303. Liu T#, Zhou YT#, Wang LQ#, Li LY#, Bao Q, Tian S, Chen MX, Chen HX, Cui J*, Li CW*. NLRP3 contributes to inflammation, pyroptosis, and mucin production in human airway epithelium upon rhinovirus infection. J Allergy Clin Immunol. 2019 May 15. pii: S0091-6749(19)30623-2. doi: 10.1016/j.jaci.2019.05.006. Liu Q#, Wu Y#, Qin Y#, Hu J, Xie W, Qin FX*, Cui J*. Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses. Sci Adv. 2018 May 2;4(5):eaar2824 Zheng Y#, Liu Q#, Wu Y#, Ma L, Zhang Z, Liu T, Jin S, She Y, Li YP*, Cui J*. Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis. EMBO J. 2018 Sep 14;37(18). pii: e99347. doi: 10.15252/embj.201899347. Epub 2018 Jul 31. Jin S#, Zhang X#, Miao Y#, Liang P, Zhu K, She Y, Wu Y, Liu DA, Huang J, Ren J*, Cui J*. m6A RNA modification controls autophagy through upregulating ULK1 protein abundance. Cell Res. 2018 Sep;28(9):955-957. doi: 10.1038/s41422-018-0069-8. Epub 2018 Jul 25 Liu K#, Zhang C#, Li B#, Xie W, Zhang J, Nie X, Tan P, Zheng L, Wu S*, Qin Y*, Cui J*, Zhi F*. Mutual Stabilization between TRIM9 Short Isoform and MKK6 Potentiates p38 Signaling to Synergistically Suppress Glioblastoma Progression. Cell Rep. 2018 Apr 17;23(3):838-851. doi: 10.1016/j.celrep.2018.03.096. Du Y#, Duan T#, Feng Y#, Liu Q, Lin M, Cui J*, Wang RF*. LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation. EMBO J. 2018 Feb 1;37(3):351-366. doi: 10.15252/embj.201796781. Epub 2017 Dec 29. Jin S#, Cui J*. BST2 inhibits type I IFN (interferon) signaling by accelerating MAVS degradation through CALCOCO2-directed autophagy. Autophagy. 2018;14(1):171-172. doi: 10.1080/15548627.2017.1393590. Epub 2017 Dec 31. Wu C#, Su Z, Lin M, Ou J, Zhao W, Cui J*, Wang RF*. NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A. Nat Commun. 2017 Dec 7;8(1):1977. doi: 10.1038/s41467-017-02073-3. Qin Y#, Su Z#, Wu Y#, Wu C, Jin S, Xie W, Jiang W, Zhou R, Cui J*. NLRP11 disrupts MAVS signalosome to inhibit type I interferon signaling and virus-induced apoptosis. EMBO Rep. 2017 Dec;18(12):2160-2171. doi: 10.15252/embr.201744480. Epub 2017 Nov 2. Feng Y#, Duan T#, Du Y#, Jin S, Wang M, Cui J*, Wang RF*. LRRC25 Functions as an Inhibitor of NF-κB Signaling Pathway by Promoting p65/RelA for Autophagic Degradation. Sci Rep. 2017 Oct 18;7(1):13448. doi: 10.1038/s41598-017-12573-3. Jin S#, Tian S, Luo M, Xie W, Liu T, Duan T, Wu Y, Cui J*. Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells. Mol Cell. 2017 Oct 19;68(2):308-322.e4. doi: 10.1016/j.molcel.2017.09.005. Epub 2017 Sep 28.

推荐链接
down
wechat
bug