Tower, John - University of Southern California, USC - Department of Biological Sciences

个人简介

John Tower received his PhD in 1988 from The Johns Hopkins University School of Medicine, Biochemistry, Cellular, and Molecular Biology Training Program, where he worked under the direction of Dr. Barbara Sollner-Webb on the topic of rDNA transcriptional regulation. He subsequently undertook postdoctoral training with Dr. Allan C. Spradling, at the Department of Embryology, Carnegie Institution of Washington, in Baltimore, where he began ongoing studies on Drosophila P element mutagenesis and chorion gene amplification. In 1991 he joined the faculty in the Department of Biological Sciences, University of Southern California, in what is now the Molecular and Computational Biology Program. Dr. Tower has been investigating the molecular genetics of aging in Drosophila since 1989, with a particular emphasis on transgenic technologies, hsps, superoxide dismutase, p53 and the role of sexual differentiation.

近期论文

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Tower, J. (2015). Mitochondrial maintenance failure in aging and role of sexual dimorphism. Arch Biochem Biophys. Vol. 576 (2014/12/03), pp. 17-31. Tower, J. (2015). Programmed cell death in aging. Ageing Res Rev. Vol. 23 (Pt A2015/04/12), pp. 90-100. Landis, G. N., Salomon, M. P., Keroles, D., Brookes, N., Sekimura, T., Tower, J. (2015). The progesterone antagonist mifepristone/RU486 blocks the negative effect on life span caused by mating in female Drosophila. Aging (Albany NY). Vol. 7 (12015/01/24), pp. 53-69. Tower, J., Landis, G., Gao, R., Luan, A., Lee, J., Sun, Y. (2014). Variegated expression of Hsp22 transgenic reporters indicates cell-specific patterns of aging in Drosophila oenocytes. J Gerontol A Biol Sci Med Sci. Vol. 69 (32013/06/01), pp. 253-9. Finch, C. E., Tower, J. (2014). Sex-specific aging in flies, worms, and missing great-granddads. Cell. Vol. 156 (32014/02/04), pp. 398-9. Shen, J., Tower, J. (2013). Aging, MnSOD, and hormesis mechanisms converge on liver mUPR. Cell Cycle. Vol. 12 (202013/09/17), pp. 3237-8. Tower, J., Landis, G., Gao, R., Luan, A., Lee, J., Sun, Y. (2013). Variegated Expression of Hsp22 Transgenic Reporters Indicates Cell-specific Patterns of Aging in Drosophila Oenocytes. J Gerontol A Biol Sci Med Sci. (2013/06/01) Shen, J., Tower, J. (2013). Aging, MnSOD, and hormesis mechanisms converge on liver mUPR. Cell Cycle. Vol. 12 (202013/09/17), pp. 3237-8. Tower, J. (2012). Stress and stem cells. Wiley Interdiscip Rev Dev Biol. Vol. 1 (62013/06/27), pp. 789-802. Landis, G., Shen, J., Tower, J. (2012). Gene expression changes in response to aging compared to heat stress, oxidative stress and ionizing radiation in Drosophila melanogaster. Aging (Albany NY). Vol. 4 (112012/12/06), pp. 768-89. Ardekani, R., Huang, Y. M., Sancheti, P., Stanciauskas, R., Tavare, S., Tower, J. (2012). Using GFP video to track 3D movement and conditional gene expression in free-moving flies. PLoS One. Vol. 7 (72012/07/26), pp. e40506. Tower, J. (2012). Stress and stem cells. Wiley Interdiscip Rev Dev Biol. Vol. 1 (62013/06/27), pp. 789-802.