McKemy, David - University of Southern California, USC

个人简介

Ph.D. Cellular & Molecular Pharmacology & Physiology, University of Nevada, Reno, 8/1999 B.S. Biochemistry, University of Nevada, Reno, 8/1991

近期论文

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McCoy, D. D., Zhuo, L., Nguyen, A., Watts, A. G., Donovan, C. M., McKemy, D. D. (2013). Enhanced insulin clearance in mice lacking TRPM8 channels. AJP-Endo Metab. Vol. In press Ramachandran, R., Hyun, E., Zhao, L., Lapointe, T. L., Chapman, K., Hirota, C. L., Ghosh, S., McKemy, D. D., Vergnolle, N., Beck, P. L., Altier, C., Hollenberg, M. D. (2013). TRPM8 activation attenuates inflammatory responses in mouse models of colitis. Proc Natl Acad Sci. Vol. 110 (18), pp. 7476-81. PubMed Web Address Knowlton, W. M., Palkar, R., Lippoldt, E. K., McCoy, D. D., Baluch, F., Chen, J., McKemy, D. D. (2013). A Sensory-Labeled Line for Cold: TRPM8-Expressing Sensory Neurons Define the Cellular Basis for Cold, Cold Pain, and Cooling-Mediated Analgesia. Journal of Neuroscience. Vol. 33 (7), pp. 2837-48. PubMed Web Address McKemy, D. D. (2013). The Molecular and Cellular Basis of Cold Sensation. ACS Chem Neuroscience. Vol. 4 (2), pp. 38-47. PubMed Web Address Osborne, M., Gomez, D., Feng, Z., McEwen, C., Beltran, J., Cirillo, K., El-Khodor, B., Lin, M. Y., Li, Y., Knowlton, W. M., McKemy, D. D., Bogdanik, L., Butts-Dehm, K., Martens, K., Davis, C., Doty, R., Wardwell, K., Ghavami, A., Kobayashi, D., Ko, C. P., Ramboz, S., Lutz, C. (2012). Characterization of behavioral and neuromuscular junction phenotypes in a novel allelic series of SMA mouse models. Hum Mol Genet. Vol. 21 (20), pp. 4431-47. PubMed Web Address Knowlton, W. M., Daniels, R. L., Palkar, R., McCoy, D. D., McKemy, D. D. (2011). Pharmacological blockade of trpm8 ion channels alters cold and cold pain responses in mice. PloS One. Vol. 6 (9), pp. e25894. PubMed Web Address McCoy, D. D., Knowlton, W. R., McKemy, D. D. (2011). Scraping through the ice: Uncovering the role of TRPM8 in cold transduction. Am J Physiol Regul Integr Comp Physiol.. Vol. 300 (6), pp. R1278-1287. PubMed Web Address McKemy, D. D. (2011). A Spicy Family Tree: TRPV1 and its Nociceptive Lineage. The Embo Journal. Vol. 30 (3), pp. 453-455. PubMed Web Address Knowlton, W. M., McKemy, D. D. (2011). TRPM8: From Cold to Cancer, Peppermint to Pain. Curr Pharm Biotechnol. Vol. 12 PubMed Web Address McKemy, D. D., Daniels, R. L. (2010). Design and Construction of a Two-Temperature Preference Behavioral Assay for Undergraduate Neuroscience Laboratories. The Journal of Undergraduate Neuroscience Education (JUNE). Vol. 9 (1), pp. A51-A56. Knowlton, W. M., Bifolck-Fisher, A., Bautista, D. M., McKemy, D. D. (2010). TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo. Pain. Vol. 150 (2), pp. 340-50. PubMed Web Address Takashima, Y., Ma, L., McKemy, D. D. (2010). The development of peripheral cold neural circuits based on TRPM8 expression. Neuroscience. Vol. 169 (2), pp. 828-42. McKemy, D. D. (2010). Therpeutic potential of TRPM8 modulators. The Open Access Drug Discovery Journal. Vol. 2, pp. 80-87. Mandadi, S., Nakanishi, S. T., Takashima, Y., Dhaka, A., Patapoutian, A., McKemy, D. D., Whelan, P. J. (2009). Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels. Neuroscience. Vol. 162 (4), pp. 1377-97. Stucky, C. L., Dubin, A. E., Jeske, N. A., Malin, S. A., McKemy, D. D., Story, G. M. (2009). Roles of transient receptor potential channels in pain. Brain Res Rev. Vol. 60 (1), pp. 2-23. Carr, R. W., Pianova, S., McKemy, D. D., Brock, J. A. (2009). Action potential initiation in the peripheral terminals of cold-sensitive neurones innervating the guinea-pig cornea. J Physiol. Vol. 587 (Pt 6), pp. 1249-64. Daniels, R. L., Takashima, Y., McKemy, D. D. (2009). Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate. J Biol Chem. Vol. 284 (3), pp. 1570-82. Wang, Y. Y., Chang, R. B., Waters, H. N., McKemy, D. D., Liman, E. R. (2008). The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions. J Biol Chem. Vol. 283 (47), pp. 32691-703. Takashima, Y., Daniels, R. L., Knowlton, W., Teng, J., Liman, E. R., McKemy, D. D. (2007). Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons. J Neurosci. Vol. 27 (51), pp. 14147-57. Daniels, R. L., McKemy, D. D. (2007). Mice left out in the cold: commentary on the phenotype of TRPM8-nulls. Mol Pain. Vol. 3, pp. 23. McKemy, D. D. (2007). Temperature sensing across species. Pflugers Arch. Vol. 454 (5), pp. 777-91. McNamara, N., Gallup, M., Sucher, A., Maltseva, I., McKemy, D. D., Basbaum, C. (2006). AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1/2. Am J Respir Cell Mol Biol. Vol. 34 (6), pp. 653-60. McKemy, D. D. (2005). How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation. Mol Pain. Vol. 1, pp. 16. Jordt, S. E., Bautista, D. M., Chuang, H. H., McKemy, D. D., Zygmunt, P. M., Hogestatt, E. D., Meng, I. D., Julius, D. (2004). Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature. Vol. 427 (6971), pp. 260-5. Jordt, S. E., McKemy, D. D., Julius, D. (2003). Lessons from peppers and peppermint: the molecular logic of thermosensation. Curr Opin Neurobiol. Vol. 13 (4), pp. 487-92.