Ko, Chien-Ping - University of Southern California, USC

个人简介

B.S. Zoology, National Taiwan University, Tawain, 5/1970 Ph.D. Physiology, Washington University, St. Louis, Missouri, 5/1975

研究领域

Professor Ko's research interests include cellular and molecular mechanisms of synaptic function, regeneration, development, remodeling and maintenance. His current research focuses on the role of the perisynaptic Schwann cell (PSC) and synapse-glial interactions at a prototype synapse, the neuromuscular junction. He is also interested in motor neuron diseases, such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Professor Ko uses transgenic mouse models to investigate various aspects of the disease mechanisms.

近期论文

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Ling, K., Gibbs, R., Feng, Z., Ko, C. (2012). Severe neuromuscular denervation of clinically relevant muscles in a mouse model of spinal muscular atrophy. Human Molecular Genetics. Vol. 21, pp. 185-195. PubMed Web Address Yoo, Y., Ko, C. (2011). Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis. Experimental Neurology. Vol. 231, pp. 147-159. PubMed Web Address Ling, K., Lin, M., Zingg, B., Feng, Z., Ko, C. (2010). Synaptic Defects in the Spinal and Neuromuscular Circuitry in a Mouse Model of Spinal Muscular Atrophy. PLoS ONE. Vol. 5 (11), pp. e15457. doi:10.1371/journal.pone.0015457. PubMed Web Address An, M., Lin, W., Yang, J., Dominguez, B., Padgett, D., Sugiura, Y., Aryal, P., Gould, T. W., Oppenheim, R. W., Hester, M. E., Kaspar, B. K., Ko, C., Lee, K. (2010). Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms. (This paper was recommended by Faculty of 1000 Biology). PNAS. Vol. 107, pp. 10702-10707. PubMed Web Address Feng, Z., Ko, C. (2008). Schwann cells promote synaptogenesis at the neuromuscular junction via Transforming Growth Factor (TGF)-beta1. (This paper was highlighted in This Week in The Journal, and recommended by Faculty of 1000 Biology). Journal of Neuroscience. Vol. 28, pp. 9599-9609.. PubMed Web Address Ko, C. (2008). Do nerve terminal sprouts contribute to functional recovery from botulinum neurotoxin A?. Journal of Physiology (Lond.). Vol. 586, pp. 3021. PubMed Web Address Feng, Z., Ko, C. (2008). The Role of Glial Cells in the Formation and Maintenance of the Neuromuscular Junction. Ann. N.Y. Acad. Sci.. Vol. 1132, pp. 19-28. PubMed Web Address Cao, G., Ko, C. (2007). Schwann cell-derived factors modulate synaptic activities at developing neuromuscular synapses. The Journal of Neuroscience. Vol. 27 (25), pp. 6712-6722. PubMed Web Address Feng, Z., Ko, C. (2007). Neuronal-glia interactions at the vertebrate neuromuscular junction. Current Opinion in Pharmacology. Vol. 7, pp. 316-324. PubMed Web Address Feng, Z., Ko, C. (2005). Synapse-Glia Interactions at the Vertebrate Neuromuscular Junction. The Neuroscientist. Vol. 11, pp. 503-513. PubMed Web Address Corfas, G., Velardez, M., Ko, C., Ratner, N., Peles, E. (2004). Mechanisms and roles of axon-Schwann cell interactions. Journal of Neuroscience. Vol. 24, pp. 9250-9260. PubMed Web Address Koirala, S., Ko, C. (2004). Pruning an axon piece by piece: a new mode of synapse elimination. Neuron. Vol. 44, pp. 578-580. PubMed Web Address Reddy, L. V., Koirala, S., Sugiura, Y., Herrera, A. A., Ko, C. (2003). Glial cells maintain synaptic structure and function and promote development of the neuromuscular junction in vivo. (This paper was recommended by Faculty of 1000 Biology). Neuron. Vol. 40, pp. 563-580. PubMed Web Address Ko, Chien-Ping and Thompson, Wesley J. (Ed.). (2003). The Neuromuscular Junction-a Special Issue. Journal of Neurocytology. Vol. 32, pp. 421-1037. Koirala, S., Reddy, L. V., Ko, C. (2003). Roles of glial cells in the formation, function, and maintenance of the neuromuscular junction. Journal of Neurocytology. Vol. 32, pp. 987-1002. PubMed Web Address Peng, H., Yang, J., Dai, Z., Lee, C., Hung, H., Feng, Z., Ko, C. (2003). Differential effects of neurotrophins and Schwann cell-derived signals on neuronal survival/growth and synaptogenesis. The Journal of Neuroscience. Vol. 23, pp. 5050-5060. PubMed Web Address Brandon, E., Lin, W., D'Amour, K., Pizzo, D., Dominguez, B., Sugiura, Y., Thode, S., Ko, C., Thal, L., Gage, F., Lee, K. (2003). Aberrant patterning of neuromuscular synapses in choline acetyltransferase deficient mice. The Journal of Neuroscience. Vol. 23, pp. 539-549. PubMed Web Address Yang, J., Cao, G., Koirala, S., Reddy, L. V., Ko, C. (2001). Schwann cells express active agrin and enhance acetylcholine receptor aggregation on muscle fibers. The Journal of Neuroscience. Vol. 21, pp. 9572-9584. PubMed Web Address