Ehrenreich, Ian - University of Southern California, USC

个人简介

B.A. Human Biology, Stanford University, 2002 Ph.D. Genetics, North Carolina State University, 2008

研究领域

We are interested in the genetic and molecular underpinnings of heritable phenotypic variation. In particular, we focus on the role that genetic variation within populations plays in altering the effects of new mutations. Additionally, we have begun to study the genetic and molecular mechanisms that give rise to novel complex traits.

近期论文

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Yuan, W., Flowers, J. M., Sahraie, D. J., Ehrenreich, I. M., Purugganan, M. D. (2016). Extreme QTL mapping of germination speed in Arabidopsis thaliana. Molecular ecology. Vol. 25 (17), pp. 4177-96. PubMed Web Address Matsui, T., Ehrenreich, I. M. (2016). Gene-Environment Interactions in Stress Response Contribute Additively to a Genotype-Environment Interaction. PLoS genetics. Vol. 12 (7), pp. e1006158. PubMed Web Address Ehrenreich, I. M., Pfennig, D. W. (2016). Genetic assimilation: a review of its potential proximate causes and evolutionary consequences. Annals of botany. Vol. 117 (5), pp. 769-79. PubMed Web Address Lee, J. T., Taylor, M. B., Shen, A., Ehrenreich, I. M. (2016). Multi-locus Genotypes Underlying Temperature Sensitivity in a Mutationally Induced Trait. PLoS genetics. Vol. 12 (3), pp. e1005929. PubMed Web Address Linder, R. A., Seidl, F., Ha, K., Ehrenreich, I. M. (2016). The complex genetic and molecular basis of a model quantitative trait. Molecular biology of the cell. Vol. 27 (1), pp. 209-18. PubMed Web Address Taylor, M. B., Phan, J., Lee, J. T., McCadden, M., Ehrenreich, I. M. (2016). Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross. Nature communications. Vol. 7, pp. 11669. PubMed Web Address Taylor, M. B., Ehrenreich, I. M. (2015). Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions. PLoS genetics. Vol. 11 (10), pp. e1005606. PubMed Web Address Matsui, T., Linder, R., Phan, J., Seidl, F., Ehrenreich, I. M. (2015). Regulatory Rewiring in a Cross Causes Extensive Genetic Heterogeneity. Genetics. Vol. 201 (2), pp. 769-77. PubMed Web Address Taylor, M. B., Ehrenreich, I. M. (2014). Higher-order genetic interactions and their contribution to complex traits. Trends in Genetics. Pfennig, D. W., Ehrenreich, I. M. (2014). Towards a gene regulatory network perspective on phenotypic plasticity, genetic accommodation and genetic assimilation. Molecular ecology. Vol. 23 (18), pp. 4438-40. PubMed Web Address Taylor, M. B., Ehrenreich, I. M. (2014). Genetic interactions involving five or more genes contribute to a complex trait in yeast. PLoS genetics. Vol. 10 (5), pp. e1004324. PubMed Web Address Bloom, J. S., Ehrenreich, I. M., Loo, W., Vo Lite, T., Kruglyak, L. (2013). Finding the sources of missing heritability in a yeast cross. Nature. Vol. 494 (7436), pp. 234-237. Jang, H., Ehrenreich, I. M. (2012). Genome-Wide Characterization of Genetic Variation in the Unicellular, Green Alga Chlamydomonas reinhardtii. PLoS ONE. Vol. 7 (7), pp. e41307. Banta, J. A., Ehrenreich, I. M., Gerard, S., Chou, L., Wilczek, A., Schmitt, J., Kover, P. X., Purugganan, M. D. (2012). Climate envelope modelling reveals intraspecific relationships among flowering phenology, niche breadth and potential range size in Arabidopsis thaliana. Ecology Letters. Vol. 15 (8), pp. 769-777. Ehrenreich, I. M., Bloom, J., Torabi, N., Wang, X., Jia, Y., Kruglyak, L. (2012). Genetic Architecture of Highly Complex Chemical Resistance Traits across Four Yeast Strains. PLoS Genetics. Vol. 8 (3), pp. e1002570. Ehrenreich, I. M., Torabi, N., Jia, Y., Kent, J., Martis, S., Shapiro, J. A., Gresham, D., Caudy, A. A., Kruglyak, L. (2010). Dissection of genetically complex traits with extremely large pools of yeast segregants. Nature. Vol. 464 (72912010/04/16), pp. 1039-42. Caicedo, A. L., Richards, C., Ehrenreich, I. M., Purugganan, M. D. (2009). Complex rearrangements lead to novel chimeric gene fusion polymorphisms at the Arabidopsis thaliana MAF2-5 flowering time gene cluster. Mol Biol Evol. Vol. 26 (32009/01/14), pp. 699-711. Ehrenreich, I. M., Gerke, J. P., Kruglyak, L. (2009). Genetic dissection of complex traits in yeast: insights from studies of gene expression and other phenotypes in the BYxRM cross. Cold Spring Harb Symp Quant Biol. Vol. 74 (2009/09/08), pp. 145-53. Ehrenreich, I. M., Hanzawa, Y., Chou, L., Roe, J. L., Kover, P. X., Purugganan, M. D. (2009). Candidate gene association mapping of Arabidopsis flowering time. Genetics. Vol. 183 (12009/07/08), pp. 325-35. Kover, P. X., Valdar, W., Trakalo, J., Scarcelli, N., Ehrenreich, I. M., Purugganan, M. D., Durrant, C., Mott, R. (2009). A Multiparent Advanced Generation Inter-Cross to fine-map quantitative traits in Arabidopsis thaliana. PLoS Genet. Vol. 5 (72009/07/14), pp. e1000551. Webb, E. A., Ehrenreich, I. M., Brown, S. L., Valois, F. W., Waterbury, J. B. (2009). Phenotypic and genotypic characterization of multiple strains of the diazotrophic cyanobacterium, Crocosphaera watsonii, isolated from the open ocean. Environ Microbiol. Vol. 11 (22009/02/07), pp. 338-48. Ehrenreich, I. M., Purugganan, M. (2008). MicroRNAs in plants: Possible contributions to phenotypic diversity. Plant Signal Behav. Vol. 3 (102009/08/26), pp. 829-30. Ehrenreich, I. M., Purugganan, M. D. (2008). Sequence variation of MicroRNAs and their binding sites in Arabidopsis. Plant Physiol. Vol. 146 (42008/02/29), pp. 1974-82. Ehrenreich, I. M., Stafford, P. A., Purugganan, M. D. (2007). The genetic architecture of shoot branching in Arabidopsis thaliana: a comparative assessment of candidate gene associations vs. quantitative trait locus mapping. Genetics. Vol. 176 (22007/04/17), pp. 1223-36. Ehrenreich, I. M., Purugganan, M. D. (2006). The molecular genetic basis of plant adaptation. American Journal of Botany. Vol. 93 (7), pp. 953-962. Ehrenreich, I. M., Waterbury, J. B., Webb, E. A. (2005). Distribution and diversity of natural product genes in marine and freshwater cyanobacterial cultures and genomes. Appl Environ Microbiol. Vol. 71 (112005/11/05), pp. 7401-13.