Tang, William - University of California, Irvine - Department of Biomedical Engineering

个人简介

Education Ph.D., University of California at Berkeley, Electrical Engineering and Computer Sciences, 1990 M.S., University of California at Berkeley, Electrical Engineering and Computer Sciences, 1982 B.S., University of California at Berkeley, Electrical Engineering and Computer Sciences, 1980

研究领域

Dr. Tang’s research focuses on studying biological systems at the micro- and nano-scales with mechanically-derived modalities. In traditional biomechanics, the human body is viewed as an intricate collection of interacting mechanical structures and systems that exhibit both static and dynamic mechanical behaviors. These studies are usually confined to the level of the entire organisms, physiological subsystems, or individual organs. The rapid advances in Micro-Electro-Mechanical Systems (MEMS) technologies offer a set of powerful tools that allows studying biomechanics at the micro scale. This will shed lights on the finer details of biomechanics, and may uncover fundamental knowledge of the origin of mechanical behaviors in living organisms.Dr. Tang is developing devices and platforms that enable both in-vitro and in-vivo studies of the mechanical aspects in physiological activities involving cells, tissues, and organs. They would be suitable for interfacing and interrogating the mechanical phenomena of interest within the targeted physiological activities at the length-scales that are beyond the reach of traditional biomedical instrumentations. His vision is that these devices and platforms will enable new research efforts to understand the significance of biomechanics at the most basic unit of life -- the cell. He also aims at enabling clinically-relevant applications that require accurate real-time data on the stress-strain distributions in the organs or physiological systems for investigation and diagnosis of the mechanical implications of health and diseases within the organs. One of the ultimate goals is to leverage the understanding in physiological phenomena researched with these tools to develop prosthetic devices to restore both sensory and motor functions that are mechanical in nature within the body.

近期论文

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C. Wu, T. G. Lin, Z. Zhan, Y. Li, S. C. H. Tung, W. C. Tang, and W. J. Li, “Fabrication of all-transparent polymer-based and encapsulated nanofluidic devices using nano-indentation lithography,” Nature: Microsyst. Nanoengin., DOI:10.1038/micronano.2016.84; 27 March 2017. B. Reddy, Jr., E. Codner, R. E. Hainley, and W. C. Tang, “Design and fabrication of field-emission tips with self-aligned gates,” Micro Nano Lett., Vol. 11, No. 9, pp. 524 – 527, 2016. R. Sahyouni, J. Bhatt, H. R. Djalilian, W. C. Tang, J. C. Middlebrooks, and H. W. Lin, “Selective stimulation of facial muscles with a penetrating electrode array in the feline model,” Laryngoscope, DOI: 10.1002/lary.26078, June 16, 2016. L. Esfandiari, M. Paff, and W. C. Tang, “Initial studies of mechanical compression on neurogenesis with neonatal neural stem cells,” Nanomed.: Nanotech., Biol., and Med., Vol. 8, No. 4, pp. 415 – 418, 2012. H. C. Wong and W. C. Tang, “Computational study of local and global ECM degradation and the effects on cell speed and cell-matrix tractions,” J. Nano Communication Networks, Vol. 2, pp. 119 – 124, 2011. Y.-H. Hsu and W. C. Tang, “Microbioreactor designed for integration with piezoelectric transducers for cellular diagnostics,” J. Microfluidics Nanofluidics, Vol. 11, No. 4, pp. 459 – 468, 2011. Y.-H. Hsu, P. Lu, J. L. Coleman, and W. C. Tang, “A microfluidic platform to isolate avian erythrocytes infected with Plasmodium gallinaceum malaria parasites based on surface morphological changes,” Biomed. Microdevices, Vol. 13, No. 6, pp. 995 – 1004, 2011. H. C. Wong and W. C. Tang, “Finite element analysis of the effects of focal adhesion mechanical properties and substrate stiffness on cell migration,” J. Biomechanics, Vol. 44, pp. 1046 – 1050, 2011. Y.-H. Hsu and W. C. Tang, “Microfabricated piezoelectric transducer platform for mechanical characterization of cellular events,” Smart Mater. Struct., Vol. 18, No. 9, on-line 095014, 2009.