Forthal, Donald - University of California, Irvine - Department of Molecular Biology and Biochemistry

研究领域

Dr. Forthal studies the immune response to viral infections. In particular, his research is focused on exploring how antibodies interact with cells of the immune system to prevent or modulate HIV and related infections. The research involves the use of in vitro and in vivo models of HIV infection with the eventual goal of developing vaccines and immunotherapies.

近期论文

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Forthal DN, Gach JS, Landucci G, Jakub J, Strasser R, Kunert R, Steinkellner H. Fc-glycosylation influences Fc? receptor binding and anti-HIV activity of monoclonal antibody 2G12. J Immunol 2010 185:6876-82. Forthal DN, Landucci G, Ding H, Kappes JC, Wang A, Thung I, Phan TB. IgG2 inhibits HIV-1 internalization by monocytes, and IgG subclass binding is differentially affected by gp120 glycosylation. AIDS 2011;25:2099-104. Rasmussen RA, Siddappa NB, Lakhashe SK, Watkins J, Villinger F, Ibegbu C, Florese RH, Robert-Guroff M, Montefiori DC, Forthal DN, O’Connor D, Ruprecht RM. High-level, lasting antiviral immunity induced by a bimodal AIDS vaccine and boosted by live-virus exposure: prevention of viremia. AIDS 2012;26:149-55. Bialuk I, Whitney S, Anresen V, Florese RH, Nacsa J, Cecchinato V, Valeri VW, Heraud J-M, Gordon S, Parks RW, Montefiori DC, Venzon D, Demberg T, Robert-Guroff M, Landucci G, Forthal DN, Franchini G. Vaccine-induced antibodies to the first variable loop of human immunodeficiency virus type 1 gp120 mediate antibody-dependent virus inhibition in macaques. Vaccine 2011;30:78-94. Barouch DH, Liu J, Li H, Maxfield LF, Abbink P, Lynch DM, Iampietro MJ, Seaman MS, Ferrari G, Forthal DN, Ourmanov I, Hirsch V, Carville A, Mansfield KG, Stablein D, Pau MG, Schuitemaker H, Sadoff JC, Billings EM, Rao M, Robb ML, Kim JH, Marovich MA, Goudsmit J Michael NL. Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys. Nature 2012;482:89-93. McBurney SP, Landucci G, Forthal DN, Ross TM. Evaluation of heterologous vaginal SHIV SF162p4 infection following vaccination with a polyvalent clade B virus-like particle vaccine. AIDS Res Hum Retrovirus 2012;28:1063-72. Moldt B, Shibata-Koyama M, Rakasz EG, Schultz N, Kristian S, Kanda Y, Watanabe T, Dunlop DC, Finstad S, Landucci G, Albert MD, Dugast A-S, Parren PWHI, Evans DT, Alter G, Forthal DN, Schmitz JE, Iida S, Poignard P, Watkins DI, Hessell AJ, Burton DR. A non-fucosylated variant of the anti-HIV-1 MAb b12 hasFc?RIIIa-mediated antiviral activity in vitro but not improved protection against mucosal SHIV challenge in macaques. J Virol 2012;86:6189-96. Forthal DN, Phan TB, Slepenkin AV, Landucci G, Chu H, Elofsson M, Peterson E. In vitro anti-HIV-1 activity of salicylidene acylhydrazide compounds. Int J Antimicrob Agents 2012;40:354-60. Van Rompay KKA, Trott KA, Jayashankar K, Geng Y, LaBranche CC, Johnson JA, Landucci G, Lipscomb J, Tarara RP, Canfield DR, Heneine W, Forthal DN, Montefiori D, Abel K. Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal. Retrovirology 2012;9:57. Forthal DN, Gabriel EE, Wang A, Landucci G, Phan TB. Association of Fc? receptor IIIa genotype with the rate of HIV infection after gp120 vaccination. Blood 2012;120:2836-42. Rosenberg Y, Sack M, Montefiori D, Forthal D, Mao L, Abanto SH, Urban L, Landucci G, Fischer R, Jiang X. Rapid High-Level Production of Functional HIV Broadly Neutralizing Monoclonal Antibodies in Transient Plant Expression Systems. PLoS One 2013;8:e58724.