Aswad, Dana W. - University of California, Irvine - Department of Molecular Biology and Biochemistry

研究领域

Regulation of protein function and gene expresssion by post-translational modification. Biochemistry of protein damage, aging, and repair. Biochemical characterization of protein pharmaceuticals.

近期论文

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Juang C, Chen B, Bru JL, Nguyen K, Huynh E, Momen M, Kim J, Aswad DW. (2017) Polymorphic Variants of Human Protein L-Isoaspartyl Methyltransferase Affect Catalytic Activity, Aggregation, and Thermal Stability; Implications for the Etiology of Neurological Disorders and Cognitive Aging. J Biol Chem. 292:3656-3665. PMID: 28100787 Pulido MA, DerHartunian MK, Qin Z, Chung EM, Kang DS, Woodham AW, Tsou JA, Klooster R, Akbari O, Wang L, Kast WM, Liu SV, Verschuuren JJ, Aswad DW, Laird-Offringa IA. (2016) Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4. J Neuroimmunol. 299:70-78. PMID: 27725125 Qin Z, Zhu JX, Aswad DW. (2016) The D-isoAsp-25 variant of histone H2B is highly enriched in active chromatin: potential role in the regulation of gene expression? Amino Acids 48(2):599-603. PMID: 26666674. Cahill L, Aswad DW. (2015) Sex Influences on the Brain: An Issue Whose Time has Come. Neuron 88(6):1084–1085. Qin Z, Dimitrijevic A, and Aswad DW (2015) Accelerated protein damage in brains of PIMT+/- mice; a possible model for the variability of cognitive decline in human aging. Neurobiology of Aging, 36:1029-36 PMID:25465735 Dimitrijevic A, Qin Z, Aswad DW. (2014) Isoaspartyl formation in creatine kinase B is associated with loss of enzymatic activity; implications for the linkage of isoaspartate accumulation and neurological dysfunction in the PIMT knockout mouse. PLoS One. 23: e100622. PMID:24955845 Qin Z, Yang J, Klassen HJ, and Aswad DW (2014) Isoaspartyl Protein Damage and Repair in Mouse Retina. Invest Ophthalmol Vis Sci. 55:1572-1579. PIMD:24550364