Gross, Steven - University of California, Irvine - Department of Developmental and Cell Biology

研究领域

Laser tweezers; Regulation of molecular motors – My research is quite cross-disciplinary. The majority of biological studies have focused on biochemical or genetic understanding of biological processes, however understanding the relevant physical processes is also important. Proteins physically do things, and to understand the biology, we must start to think about proteins as machines, as well as considering their biochemical properties and genetic regulation. We will soon know the Human Genome, we already know the Drosophila and the C. Elegans Genomes, and yet are very far from understanding how proteins work, and how the exquisitely ordered structures we observe in cells, embryos, and developed organisms come about. Cytoskeletal processes such as transport are important in the creation of this order, and my lab is attempting to develop and apply physical tools to quantify transport as it occurs in living cells.

近期论文

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K.P. Bohannon, Y. Jun, S.P. Gross, and G.A. Smith, “Differential protein partitioning within the herpesvirus tegument and envelope underlie a complex and variable virion architecture.”, PNAS, in press, (2013). S. P. Gross, “Come together: group behavior of Dynein motors.”, Dev. Cell. Jan 28; 24(2):117-8. (2013) R.P. Erickson, S.P. Gross+†, and C.C. Yu+†, “Filament-Filament Switching Can Be Regulated by Separation Between Filaments Together with Cargo Motor Number”, PLOS one, 8(2):e54298 (2013). P. Anand*, S. Cermelli*, Z. Li, A. Kassan, M. Bosch, R. Sigua, L. Huang, A.J. Ouellette, A. Pol, M.A Welte, and S.P. Gross, “A novel role for lipid droplets in the organismal antibacterial response”, eLife, November 13 (2012). J. Xu, Z. Shu, S.J. King, and S.P. Gross, “Tuning Multiple Motor Travel Via Single Motor Velocity”, Traffic, March 27, (2012). J. Lee, S. P. Gross, and J. Lee, “Modularity optimization by conformational space annealing”, Phys. Rev. E, 85(5 pt 2) (2012). R. Sigua, S. Tripathy, P. Anand+†, and S.P. Gross+†, “Isolation and Purification of Kinesin from Drosophila Embryos”, J. Vis. Exp. (62), e3501, DOI: 10.3791/3501 (2012). J. Xu, B.J. N. Reddy*, P. Anand,*, Z. Shu,*, S. Cermelli, M.K. Mattson, S.K. Tripathy, M.T. Hoss, N.S. James, S.J. King, L. Huang, L. Bardwell and S.P. Gross+†, “Casein kinase 2 reverses tail-independent inactivation of kinesin-1”, Nature Communications, March 27, (2012). PMID: 22453827 M. Bosch, M. Marí, S.P. Gross, J.C. Fernández-Checa, and A. Pol, “Mitochondrial cholesterol: a connection between caveolin and metabolism”, Traffic 12(11) (2011). J. Yi, K. Ori-McKenney, R. McKenney, M. Vershinin, S.P. Gross, and R. B. Vallee, “High Resolution Imaging Reveals Indirect Coordination of Opposite Motors and LIS1 Role in High-load Axonal Transport.”, in press. J. Cell Biol., (2011). PMID: 22006948