Gardiner, David - University of California, Irvine - Department of Developmental and Cell Biology

研究领域

Limb development and regeneration – How to Regenerate a New Leg: What we can learn from salamanders – Alone among vertebrates, urodele amphibians are able to regenerate lost body parts as adults. The key to this ability is that limb cells are triggered to dedifferentiate and reinitiate growth and pattern formation. Our strategy is to use axolotls (Ambystoma mexicanum) to discover the signals that trigger the regeneration response, in the belief that these signals have enormous potential and consequences for human health. Our long term goals are to identify the regeneration-enabling signals in limbs, in order to support progress towards the eventual application of these molecules to the improvement of human repair mechanisms.

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Aguilar, C. and Gardiner, D. M. (2015). DNA methylation dynamics regulate the formation of a regenerative wound epithelium during axolotl limb regeneration. PLoS One, 2015, 10(8): e0134791. doi:10.1371/journal.pone.0134791. Phan, A.Q., Lee, J., Oei, M., Flath, C., Hwe, C., Mariano, R., Vu, T, Shu, C., Muneoka, K., Bryant, S.V., and Gardiner, D.M. (2015) Heparan Sulfates Mediate Positional Information by Position-Specific Growth Factor Regulation during Axolotl (Ambystoma mexicanum) Limb Regeneration. REGENERATION. 2015 August 11, DOI: 10.1002/reg2.40. McCusker, C., Gardiner, D.M and Bryant, S.V. (2015). The Axolotl limb blastema: cellular and molecular mechanisms driving blastema formation and limb regeneration in tetrapods. REGENERATION. 2015 May 11, DOI: 10.1002/reg2.32 Lehrberg, J. and Gardiner, D.M. (2015). Regulation of axolotl (Ambystoma mexicanum) limb blastema cell proliferation by nerves and BMP2. PLoS One. 2015, PONE-D-14-52826. Endo, T., Gardiner, D.M., Makanae, A., and Satoh, A. (2015). The Accessory Limb Model: An alternative experimental system of limb regeneration. Meth. Mol. Biol. 1290:101-113. Voss, R., Palumbo, A., Nagarajan, R., Gardiner, D.M., Muneoka, K., Stromberg, A., Athipopozhy, A. Gene Expression During the First 28 Days of Axolotl Limb Regeneration I: Experimental Design and Global Analysis of Gene Expression (2015). REGENERATION. 2015 June 19, DOI: 10.1002/reg2.37 McCusker, C. and Gardiner, D.M. (2014). Understanding positional cues in salamander limb regeneration: implications for optimizing cell-based regenerative therapies. Disease Models & Mechanisms. 7: 593-599. Athippozhy, A., Lehberg, J., Monaghan, J. R., Tsai, S., Gardiner, D. M., and Voss S.R. (2014). Characterization of in vitro transcriptional responses of dorsal root ganglia cultured in the presence and absence of blastema cells from regenerating salamander limbs. REGENERATION. 2014 July 4, DOI: 10.1002/reg2.14 McCusker, C, Lehrberg, J. and Gardiner, D.M. (2014) Position-specific induction of ectopic limbs in non-regenerating blastemas on Axolotl forelimbs. REGENERATION. 2014 Feb 16, DOI: 10.1002/reg2.10.