Wu, Lily - University of California, Los Angeles

个人简介

Professor, Molecular & Medical Pharmacology Associate Professor, Pediatrics, Urology Member, CTSI, California NanoSystems Institute, JCCC Cancer Molecular Imaging, JCCC Genitourinary Oncology Program Area, Molecular Pharmacology GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area Investigator, Workforce Development

研究领域

Our research is aimed at developing a better understanding of cancer biology and creating an improved gene-based therapy by exploiting special properties of the adenovirus. We have utilized the efficient gene transfer property of adenovirus to create improved, tissuetargeted therapeutic strategies for cancer. By applying this targeted gene-expression approach to molecular imaging, metastatic lesions were detected in living tumor-bearing mice. Transcriptional targeted approaches are being developed to express the different therapeutic genes and imaging genes in prostate and breast cancer models. In a second strategy, we are exploiting the distributive property of the adenovirus and use it to investigate tumor vasculatures and cancer metastasis. As a third strategy, the viral replication property is usurped to create cancer-specific lysis. Molecular imaging techniques such as optical CCD imaging and positron emission tomography (PET) are fundamental tools of our investigation. Our ultimate goal is to create a potent and effective cancer-targeted gene therapy to diagnose and treat advanced stage and metastatic cancer.

近期论文

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Pouliot FrÃ©dÃ©ric, Sato Makoto, Jiang Ziyue Karen, Huyn Steve, Karanikolas Breanne Dw, Wu Lily A molecular imaging system based on both transcriptional and genomic amplification to detect prostate cancer cells in vivo. Molecular therapy : the journal of the American Society of Gene Therapy. 2013; 21(3): 554-60. Xu Jingying, Escamilla Jemima, Mok Stephen, David John, Priceman Saul, West Brian, Bollag Gideon, McBride William, Wu Lily CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer. Cancer research. 2013; 73(9): 2782-94. Jiang Ziyue Karen, Koh Sok Boon S, Sato Makoto, Atanasov Ivo C, Johnson Mai, Zhou Z Hong, Deming Timothy J, Wu Lily Engineering polypeptide coatings to augment gene transduction and in vivo stability of adenoviruses. Journal of controlled release : official journal of the Controlled Release Society. 2013; 166(1): 75-85. Jiang Ziyue Karen, Sato Makoto, Wu Lily Chapter five--The development of transcription-regulated adenoviral vectors with high cancer-selective imaging capabilities. Advances in cancer research. 2012; 115(15): 115-46. He Huanhuan, Xu Jingying, Warren Carmen M, Duan Dan, Li Xinmin, Wu Lily, Iruela-Arispe M Luisa Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages. Blood. 2012; 120(15): 3152-62. Wu Lily, Grigoryan Arsen V, Li Yunfeng, Hao Bing, Pagano Michele, Cardozo Timothy J Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chemistry & biology. 2012; 19(12): 1515-24. Chen Kuan-Ju, Wolahan Stephanie M, Wang Hao, Hsu Chao-Hsiung, Chang Hsing-Wei, Durazo Armando, Hwang Lian-Pin, Garcia Mitch A, Jiang Ziyue K, Wu Lily, Lin Yung-Ya, Tseng Hsian-Rong A small MRI contrast agent library of gadolinium(III)-encapsulated supramolecular nanoparticles for improved relaxivity and sensitivity. Biomaterials. 2011; 32(8): 2160-5. Jiang Ziyue Karen, Sato Makoto, Wei Liu H, Kao Chinghai, Wu Lily Androgen-independent molecular imaging vectors to detect castration-resistant and metastatic prostate cancer. Cancer research. 2011; 71(19): 6250-60. Liu Hongrong, Wu Lily, Zhou Z Hong Model of the trimeric fiber and its interactions with the pentameric penton base of human adenovirus by cryo-electron microscopy. Journal of molecular biology. 2011; 406(5): 764-74.