个人简介

B.S., University of Virginia; A.M., Ph.D., Harvard University; Postdoctoral Fellow, University of California, Berkeley

研究领域

Organic chemistry, organic synthesis

Our research addresses the development of new methods and reactions for organic synthesis. My laboratory examines transformations with unusual reaction mechanisms that provide insight into fundamental chemical reactivity. As part of this program, we have studied the reactions of strained ring silanes, which led us to develop new reactions of silylenes and to examine the applications of these species in organic synthesis. We have also advanced the understanding of the structures and reactions of oxocarbenium ions, and we have developed stereoelectronic models that explain and predict their reactivity. Our applications of allylic silane chemistry to the synthesis of heterocycles led to the development of several syntheses of natural products, including erythronolide A. We are developing methods for the synthesis of organic peroxides, a family of compounds that includes a large number of biologically active natural products.

近期论文

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"Erosion of Stereochemical Control with Increasing Nucleophilicity: O-Glycosylation at the Diffusion Limit." M. G. Beaver, K. A. Woerpel, J. Org. Chem. 2010, 75, 1107-1118. "Insertions of Silylenes into Vinyl Epoxides: Diastereoselective Synthesis of Functionalized, Optically Active trans-Dioxasilacyclooctenes." M. Provost, K. A. Woerpel, J. Am. Chem. Soc. 2009, 131, 14182-14183. "Palladium(II)-Catalyzed Cyclization of Unsaturated Hydroperoxides for the Synthesis of 1,2-Dioxanes." J. R. Harris, S. R. Waetzig, K. A. Woerpel, Org. Lett. 2009, 11, 3290-3293. "Alkylidenesilacyclopropanes Derived from Allenes: Applications to the Selective Synthesis of Triols and Homoallylic Alcohols." K. M. Buchner, T. B. Clark, J. M. N. Loy, T. X. Nguyen, K. A. Woerpel, Org. Lett. 2009, 11, 2173-2175. "Formation of Medium-Sized Nitrogen Heterocycles from γ-Silyloxy-γ-Lactams." N. M. Leonard, K. A. Woerpel, J. Org. Chem. 2009, 74, 6915-6923. "Preparation of Bicyclic 1,2,4-Trioxanes from γ,d-Unsaturated Ketones." A. P. Ramirez, A. M. Thomas, K. A. Woerpel, Org. Lett. 2009, 11, 507-510. "The Effect of Electrostatic Interactions on Conformational Equilibria of Multiply-Substituted Tetrahydropyran Oxocarbenium Ions." M. T. Yang, K. A. Woerpel, J. Org. Chem. 2009, 72, 545-553. "C-Glycosylation Reactions of Sulfur-Substituted Glycosyl Donors: Evidence Against the Role of Neighboring-Group Participation." M. G. Beaver, S. B. Billings, K. A. Woerpel, J. Am. Chem. Soc. 2008, 130, 2082-2086.