Traaseth, Nathaniel J. - New York University

个人简介

B.S., University of Minnesota-Duluth; Ph.D., University of Minnesota; Postdoctoral Fellow, University of Minnesota

研究领域

NMR Spectroscopy, Physical Chemistry, Chemical Biology, Biophysics, Structural Biology Our research is focused on revealing the transport mechanism of membrane proteins through determination of their structures. Membrane transport proteins regulate cellular events by acting as gatekeepers of ions, drugs, and other essential molecules. Our broader interest is in engineering new drugs and proteins that elicit tailored biological responses. In order to characterize these challenging systems, we primarily rely on nuclear magnetic resonance spectroscopy (solution and solid-state NMR).

近期论文

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Banigan JR, Gayen A, Cho MK, Traaseth NJ (2015) A Structured Loop Modulates Coupling Between the Substrate-Binding and Dimerization Domains in the Multidrug Resistance Transporter EmrE. J Biol Chem, 290, 805-14. [pdf] Cho MK+, Gayen A+, Banigan JR, Leninger M, Traaseth NJ (2014) The Intrinsic Conformational Plasticity of Native EmrE Provides a Pathway for Multidrug Resistance. J Am Chem Soc, 136, 8072-80. (+equal contribution) [pdf] Banigan JR, Gayen A, Traaseth NJ (2014) Correlating Lipid Bilayer Fluidity with Sensitivity and Resolution of Polytopic Membrane Protein Spectra by Solid-State NMR Spectroscopy. Biochim Biophys Acta, 1848, 334-41. [pdf] Kushal S, Lao BB, Henchey LK, Dubey R, Mesallati H, Traaseth NJ, Olenyuk BZ, Arora PS (2013) Protein Domain Mimetics as in vivo Modulators of Hypoxia-Inducible Factor Signaling. Proc Natl Acad Sci, 110, 15602-7. [pdf] Gayen A, Banigan JR, Traaseth NJ (2013) Ligand-Induced Conformational Changes of the Multidrug Resistance Transporter EmrE Probed by Oriented Solid-State NMR Spectroscopy. Angew Chemie Int Ed, 52, 10321-4. [pdf] Chen H, Huang Z, Dutta K, Blais S, Neubert TA, Li X, Cowburn D, Traaseth NJ, Mohammadi M (2013) Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Pathogenic Gain-of-Function Mutations. Cell Reports, 4(2), 376-84.[pdf]. Banigan JR, Gayen A, Traaseth NJ (2013) Combination of 15N Reverse Labeling and Afterglow Spectroscopy for Assigning Membrane Protein Spectra by Magic-Angle-Spinning Solid-State NMR: Application to the Multidrug Resistance Protein EmrE. J Biomolec NMR, 55, 391-9.[pdf] Banigan JR and Traaseth NJ (2012) Using Afterglow Magnetization from Cross-Polarization Magic-Angle-Spinning Solid-State NMR Spectroscopy to Obtain Simultaneous Heteronuclear Multidimensional Spectra. J Phys Chem B, 116, 7138-44.[pdf] Traaseth NJ, Chao F.A., Masterson LR, Mangia S, Garwood M, Michaeli S, Seelig B, Veglia G (2012) Heteronuclear Adiabatic Relaxation Dispersion (HARD) for Quantitative Analysis of Conformational Dynamics in Proteins. J Magn Reson, 219, 75-82. [pdf] Verardi R, Traaseth NJ, Masterson LR, Vostrikov VV, Veglia G. (2012) Isotope Labeling for Solution and Solid-state NMR Spectroscopy of Membrane Proteins. Adv Exp Med Biol, 992, 35-62. [pdf] Gustavsson M, Verardi R, Mullen DG, Mote KR, Traaseth NJ, Gopinath T, Veglia G (2013) Allosteric Regulation of SERCA by Phosphorylation-Mediated Conformational Shift of Phospholamban. Proc Natl Acad Sci, 110, 17338-43. [pdf] Veglia G, Traaseth NJ, Shi L, Verardi R, Gopinath T, Gustavsson M (2012) The Hybrid Solution/Solid-State NMR Method for Membrane Protein Structure Determination. Comprehensive Biophysics, 1, 182-198. [pdf] Gustavsson M, Traaseth NJ, Veglia G (2012) Probing Ground and Excited States of Phospholamban in Model and Native Lipid Membranes by Magic Angle Spinning NMR. Biochim Biophys Acta, 1818, 146-53. [pdf] Gustavsson M, Traaseth NJ, Veglia G (2011) Activating and Deactivating Roles of Lipid Bilayers on the Ca2+-ATPase/Phospholamban Complex. Biochemistry, 50, 10367-74. [pdf] Mote KR, Gopinath T, Traaseth NJ, Veglia G (2011) Multidimensional Oriented Solid-State NMR Experiments Enable the Sequential Assignment of Uniformly 15N Labeled Integral Membrane Proteins in Magnetically Aligned Lipid Bilayers. J Biomol NMR, 51, 339-46. [pdf] Gaffarogullari EC, Masterson LR, Metcalfe EE, Traaseth NJ, Balatri E, Musa MM, Mullen D, Distefano MD, Veglia G (2011) A Myristoyl/Phosphoserine Switch Controls camp-Dependent Protein Kinase Association to Membranes. J Mol Biol, 411, 823-36. [pdf] Verardi R, Shi L, Traaseth NJ, Walsh N, Veglia G (2011) Structural Topology of Phospholamban Pentamer in Lipid Bilayers by a Hybrid Solution and Solid-State NMR Method. Proc Natl Acad Sci, 108, 9101-6. [pdf] Traaseth NJ, Veglia G (2011) Frequency-Selective Heteronuclear Dephasing and Selective Carbonyl Labeling to Deconvolute Crowded Spectra of Membrane Proteins by Magic Angle Spinning NMR. J Magn Reson, 211, 18-24. [pdf] Gustavsson M, Traaseth NJ, Karim CB, Lockamy EL, Thomas DD, Veglia G (2011) Lipid-Mediated Folding/Unfolding of Phospholamban as a Regulatory Mechanism for the Sarcoplasmic Reticulum Ca(2+)-ATPase. J Mol Biol, 408, 755-65. [pdf] Shi L, Traaseth NJ, Verardi R, Gustavsson M, Gao J, Veglia G (2011) Paramagnetic-based NMR Restraints Lift Residual Dipolar Coupling Degeneracy in Multidomain Detergent-Solubilized Membrane Proteins. J Am Chem Soc, 133, 2232-41. [pdf]