Morandi Bill - Max-Planck-Institut für Kohlenforschung -

个人简介

since July 2014 Founder and leader (W2/Associate Professor without tenure) of the “homogeneous catalysis and reaction design” group, an independent Max Planck Research Group at the Max Planck Institut für Kohlenforschung 2012-2014 Postdoctoral Studies (supported by the Swiss National Science Foundation) in organometallic chemistry at the California Institute of Technology (Prof. Grubbs) 2008-2012 Doctoral Studies (supported by the Stipendienfonds der Schweizerischen Chemischen Industrie (SSCI)) in organic chemistry at the ETH Zurich (Prof. Carreira) 2008 MSc in Biological Chemistry from the ETH Zurich supported by an Oskar-Jeger Scholarship. Master Thesis under the supervision of Prof. Carreira 2006 BSc in Biology from the ETH Zurich 1983 born in Fribourg, Switzerland

研究领域

Shuttle Catalysis Catalytic reversible reactions, such as alkene metathesis and transfer hydrogenation, have had an auspicious impact on the molecular sciences. We are currently developing “shuttle catalysis” reactions that parallel the mechanism of transfer hydrogenation through the reversible transfer of chemical moieties beyond hydrogen, to address synthetically relevant challenges in catalysis and provide new disconnections for synthetic chemists. Aliphatic C-O Bond Activation The alcohol group is one the most widespread functional groups in organic synthesis. Additionally, alcohols are ubiquitous in renewable feedstocks, such as carbohydrate derivatives. Therefore, methods for the transformation and functionalization of alcohols are in high demand in synthesis. The research area “aliphatic C–O bond activation” targets the development of novel transformations employing alcohol derivatives as starting materials, with a particular emphasis on the selective functionalization of polyol derivatives. Direct Catalytic Synthesis of Unprotected Amines The formation of C–N bonds is one of the major challenges in the preparation of bioactive molecules. The direct catalytic amination of hydrocarbons is an attractive approach to address this challenge and has been the subject of intense research efforts. However, most of the methods developed thus far lead to the installation of a protected form of the versatile primary amine group, requiring additional and often challenging protecting group manipulations. In contrast, the research program “Direct Catalytic Synthesis of Unprotected Amines” circumvents the protecting group limitation by enabling a direct access to the desired primary amine. Besides its synthetic potential, this project also addresses a fundamental challenge in catalysis, namely the synthesis of unprotected functionalized molecules that are prone to deactivating coordination of metal catalysts.

近期论文

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Chatterjee, S., Makai, S., & Morandi, B. (2021). Hydroxylamine‐Derived Reagent as a Dual Oxidant and Amino Group Donor for the Iron‐Catalyzed Preparation of Unprotected Sulfinamides from Thiols. Angewandte Chemie International Edition, 60(2), 758-765. doi:10.1002/anie.202011138. Delcaillau, T., Bismuto, A., Lian, Z., & Morandi, B. (2020). Nickel‐Catalyzed Inter‐ and Intramolecular Aryl Thioether Metathesis by Reversible Arylation. Angewandte Chemie, International Edition, 59(5), 2110-2114. doi:10.1002/anie.201910436. Yu, P., Bismuto, A., & Morandi, B. (2020). Iridium‐Catalyzed Hydrochlorination and Hydrobromination of Alkynes by Shuttle Catalysis. Angewandte Chemie, International Edition, 59(7), 2904-2910. doi:10.1002/anie.201912803. Bhawal, B. N., Reisenbauer, J. C., Ehinger, C., & Morandi, B. (2020). Overcoming Selectivity Issues in Reversible Catalysis: A Transfer Hydrocyanation Exhibiting High Kinetic Control. Journal of the American Chemical Society, 142(25), 10914-10920. doi:10.1021/jacs.0c03184. Lee, Y. H., & Morandi, B. (2019). Transition metal-mediated metathesis between P–C and M–C bonds: Beyond a side reaction. Coordination Chemistry Reviews, 386(5), 96-118. doi:10.1016/j.ccr.2018.12.001. Lee, Y. H., & Morandi, B. (2019). Palladium‐Catalyzed Intermolecular Aryliodination of Internal Alkynes. Angewandte Chemie International Edition, 58(19), 6444-6448. doi:10.1002/anie.201812396. Fang, X., Yu, P., Willems, S., & Morandi, B. (2019). Nickel‐Catalyzed Cascade Annulation for the Rapid Synthesis of Carbocyclic Nitriles. Helvetica Chimica Acta, 102(5): e1900059. doi:10.1002/hlca.201900059. Bhawal, B. N., & Morandi, B. (2019). Catalytic Isofunctional Reactions—Expanding the Repertoire of Shuttle and Metathesis Reactions. Angewandte Chemie International Edition, 58(30), 10074-10103. doi:10.1002/anie.201803797. Lee, Y. H., & Morandi, B. (2018). C–H carbonylation: In situ acyl triflates ace it. Nature Chemistry, 10(2), 116-117. doi:10.1038/nchem.2934. Cheng, G.-J., Drosos, N., Morandi, B., & Thiel, W. (2018). Computational Study of B(C6F5)3-Catalyzed Selective Deoxygenation of 1,2-Diols: Cyclic and Noncyclic Pathways. ACS Catalysis, 8(3), 1697-1702. doi:10.1021/acscatal.7b04209. Biberger, T., Makai, S., Lian, Z., & Morandi, B. (2018). Iron‐Catalyzed Ring‐Closing C−O/C−O Metathesis of Aliphatic Ethers. Angewandte Chemie International Edition, 57(23), 6940-6944. doi:10.1002/anie.201802563. Bhawal, B. N., & Morandi, B. (2018). Isodesmic Reactions in Catalysis – Only the Beginning? Israel Journal of Chemistry, 58(1-2), 94-103. doi:10.1002/ijch.201700116. Lee, Y. H., & Morandi, B. (2018). Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides. Nature Chemistry, 10(10), 1016-1022. doi:10.1038/s41557-018-0078-8. Legnani, L., Prina Cerai, G., Delcaillau, T., Willems, S., & Morandi, B. (2018). Efficient access to unprotected primary amines by iron-catalyzed aminochlorination of alkenes. Science, 362(6413), 434-438. doi:10.1126/science.aat3863. Lee, Y. H., & Morandi, B. (2018). C–H carbonylation: In situ acyl triflates ace it. Nature Chemistry, 10(2), 116-117. doi:10.1038/nchem.2934. Cheng, G.-J., Drosos, N., Morandi, B., & Thiel, W. (2018). Computational Study of B(C6F5)3-Catalyzed Selective Deoxygenation of 1,2-Diols: Cyclic and Noncyclic Pathways. ACS Catalysis, 8(3), 1697-1702. doi:10.1021/acscatal.7b04209. Biberger, T., Makai, S., Lian, Z., & Morandi, B. (2018). Iron‐Catalyzed Ring‐Closing C−O/C−O Metathesis of Aliphatic Ethers. Angewandte Chemie International Edition, 57(23), 6940-6944. doi:10.1002/anie.201802563. Bhawal, B. N., & Morandi, B. (2018). Isodesmic Reactions in Catalysis – Only the Beginning? Israel Journal of Chemistry, 58(1-2), 94-103. doi:10.1002/ijch.201700116. Lee, Y. H., & Morandi, B. (2018). Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides. Nature Chemistry, 10(10), 1016-1022. doi:10.1038/s41557-018-0078-8. Legnani, L., Prina Cerai, G., Delcaillau, T., Willems, S., & Morandi, B. (2018). Efficient access to unprotected primary amines by iron-catalyzed aminochlorination of alkenes. Science, 362(6413), 434-438. doi:10.1126/science.aat3863.