Liu, Aimin - University of Texas at San Antonio

个人简介

EDUCATION 1997-1999 Ph.D., Biochemistry and Biophysics, Department of Biochemistry and Biophysics,Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm,Sweden Thesis: The interaction between iron and the protein radical in aerobic and anaerobic ribonucleotide reductase. Advisor: Professor Astrid Gräslund 1986-1991 Ph.D., Physical Chemistry, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P. R. China, Advisor: Professor Shu-Ben Li 1981-1986 B.S., Chemistry, Department of Chemistry, University of Science and Technology of China (USTC), Hefei, P. R. China PROFESSIONAL EMPLOYMENT 01/2016-present Professor of Chemistry and Lutcher Brown Distinguished Chair in Biochemistry,Department of Chemistry, The University of Texas at San Antonio, San Antonio,TX 01/2015-01/2016 Distinguished University Professor, Department of Chemistry, Georgia State University, Atlanta, GA 08/2012-01/2015 Professor of Chemistry and Biochemistry (tenured), Department of Chemistry,Georgia State University, Atlanta, GA 08/2009-01/2016 Georgia Research Alliance-Georgia Cancer Coalition Distinguished Scholar, The State of Georgia 08/2008-07/2012 Associate Professor of Chemistry and Biochemistry, Department of Chemistry, Georgia State University, Atlanta, GA 06/2008-08/2008 Associate Professor of Biochemistry (tenured), Department of Biochemistry,University of Mississippi Medical Center, Jackson, MS 05/2008 Visiting Professorship, May 7- June 8, 2008, Kansai University, Japan 10/2002-06/2008 Assistant Professor of Biochemistry (tenure-track), Department of Biochemistry,University of Mississippi Medical Center, Jackson, MS

研究领域

RESEARCH INTEREST Amino acid metabolism (cysteine, tryptophan, and tyrosine) Amino acid crosslink-derived protein cofactors Amino acid oxidations among over 500 natural amino acids for natural product biosynthesis Mechanistic Enzymology and redox biology Antimicrobial and anticancer drug discovery Cancer immunotherapy strategies Metalloprotein-mediated redox sensing and signaling mechanisms AREA OF EXPERTISE Primary techniques: EPR, ENDOR, and resonance Raman spectroscopies, stopped-flow kinetics, rapid chemical/freeze-quench, isothermal titration calorimetry, LC-MS, and NMR, X-ray protein crystallography, cryo-EM (evolving)

近期论文

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ACMSD catalyzes the enol/keto tautomerization of oxaloacetate Yang Y*, Davis, Altman, and Liu A*Manuscript submitted for peer review (MS # JBC-D-24-01541) Decoding MYW-OOH: Indole-N-linked hydroperoxyl modification modulating Mycobacterium tuberculosis KatG function Li J, Duan R, Traore ES, Davis I, Nguyen RC, Griffith WP, Goodwin DC, Jarzecki AA, and Liu A*Manuscript submitted for peer review (MS # 202407018) Cobalt(II)-substituted cysteamine dioxygenase oxygenation proceeds through a cobalt(III)-superoxo complex Li J*, Duan R, and Liu A* J. Am. Chem, Soc., 2024, 146, 27, 18292–18297 (DOI: 10.1021/jacs.3c04991) Unveiling the mechanism of cysteamine dioxygenase: A combined HPLC-MS assay and metal-substitution approach Duan R, Li J, and Liu A* Methods in Enzymology, 2024, 703, 2589 (DOI: 2510.1016/bs.mie.2024.2505.2018) Indole-N-linked hydroperoxyl in Mycobacterium tuberculosis KatG Li J, Duan R, Traore ES, Davis I, Nguyen RC, Goodwin DC, Jarzecki AA, and Liu A* Manuscript submitted for peer review (10/09/2023, ms# 2023-17099) In situ structural observation of a substrate- and peroxide-bound high-spin ferric- hydroperoxo intermediate in P450 enzyme CYP121 Nguyen RC, Davis I, Dasgupta M, Wang Y, Simon P, Butryn A, Makita H, Bogacz I, Dornevil K, Aller P, Bhowmick A, Chatterjee R, Kim I-S, Zhou T, Mendez D, Paley, D, Fuller F, Alonso Mori R, Batyuk A, Sauter N, Brewster A, Orville AM, Yachandra V, Yano J, Kern J,* and Liu A* J. Am. Chem, Soc., 2023, in press (DOI: 10.1021/jacs.3c04991) Structural and spectroscopic characterization of RufO indicates a new biological role in rufomycin biosynthesis Jordan S, Li B, Traore ES, Wu Y, Usai R, Liu A, Xie ZR, Wang Y* J. Biol. Chem., 2023, 299(8) 105049 (DOI: 10.1016/j.jbc.2023.105049) Simultaneous separation and detection of nine kynurenine pathway metabolites by reversed-phase liquid chromatography-mass spectrometry: Quantitation of inflammation in human cerebrospinal fluid and plasma Patel VD, Shamsi SA*, Miller A, Liu A, and Powell M Anal. Chim. Acta, 2023, 1278, 341659 (DOI: 10.1016/j.aca.2023.341659) Structural insights into the half-of-sites reactivity in homodimeric and homotetrameric metalloenzymes Nguyen RC, Stagliano C, and Liu A* Curr. Opin. Chem. Biol., 2023, 75, 102332 (DOI: 10.1016/j.cbpa.2023.102332) Kynurenine pathway regulation at its critical junctions with fluctuation of tryptophan Newton A, McCann L, Huo L, and Liu A* Metabolites, 2023, 13, 500, 1-13 (DOI: 10.3390/metabo13040500) Quantitation of tryptophan and kynurenine in human plasma using 4-vinylphenylboronic acid column by capillary electrochromatography coupled with mass spectrometry Patel VD, Shamsi SA*, Miller A, and Liu A Electrophoresis, 2023, 44, 529-539 (DOI: 10.1002/elps.202200251) Charge maintenance during catalysis in non-heme iron oxygenases Traore ES and Liu A* ACS Catalysis, 2022, 14(10), 6191-6208 (DOI: 10.1021/acscatal.1c04770) Probing extradiol dioxygenase mechanism in NAD+ biosynthesis by viewing the reaction cycle intermediates Davis I, Geng J, and Liu A* Encyclopedia of Inorganic and Bioinorganic Chemistry, 2022, 1-8 (DOI: 10.1002/9781119951438.eibc2813) Metalloenzymes involved in carotenoid biosynthesis in plants Davis I*, Geng J, and Liu A* Methods Enzymol., 2022, 671, 207-222 (DOI: 10.1016/bs.mie.2022.01.012) A new regime of the histidyl-ligated heme-dependent oxygenase superfamily Shin I, Wang Y, and Liu A* Proc. Natl. Acad. Sci. U.S.A., 2021, 118(43), 2021, 118(43), e210656, 1-10 (DOI: 10.1073/pnas.2106561118) (PNAS direct submission) Crystal structure of human cysteamine dioxygenase provides a structural rationale for its function as an oxygen sensor Wang Y, Shin I, Li J, and Liu A* J. Biol. Chem., 2021, 297(4), 101176, 1-10 (DOI: 10.1016/j.jbc.2021.101176) HygY is a twitch radical SAM epimerase with latent dehydrogenase activity revealed upon mutation of a single cysteine residue Besandre R, Chen Z, Davis I, Zhang J, Ruszczycky M, Liu A and Liu H-w* J. Am. Chem. Soc., 2021, 143(37), 15152–15158 (DOI: 10.1021/jacs.1c05727) Capillary electrochromatography-mass spectrometry of kynurenine pathway metabolites Chawdhury A, Shamsi S.A.*, Miller A, and Liu A J. Chromatogr. A. 2021, 1651, 462294 (1-14) (DOI: 10.1016/j.chroma.2021.462294) Molecular rationale for partitioning between C-H and C-F bond activation in heme- dependent tyrosine hydroxylase Wang Y, Davis I, Shin I, Xu H, and Liu A* J. Am. Chem. Soc. 2021, 143(12), 4680-4693 (DOI: 10.1021/jacs.1c00175) A novel catalytic heme cofactor in SfmD with a single thioether bond and a bis-His Ligand set revealed by de novo crystal structural and spectroscopic study Shin I, Davis I, Nieves-Merced K, Wang Y, McHardy, and Liu A* Chem. Sci. 2021, 12(11), 3984-3998 (Edge Article) (DOI: 10.1039/D0SC06369J) Heme binding to HupZ with a C-terminal tag from Group A Streptococcus Traore ES, Li J, Chiura T, Geng J, Sachla A, Yoshimoto F, Eichenbaum Z, Davis I, Max P*, and Liu A*Molecules 2021, 26(3), 549, 1-19 (DOI: 10.3390/molecules26030549) Diflunisal derivatives as modulators of ACMS decarboxylase targeting the tryptophankynurenine pathway Yang Y, Borel T, de Azambuja F, Johnson D, Sorrentino JP, Udokwu C, Davis I,Liu A*, Altman R* J. Med. Chem., 2021, 64(1), 797–811 (DOI: 10.1021/acs.jmedchem.0c01762) Formation of monofluorinated radical cofactor in galactose oxidase through copper-mediated C−F bond scission Li J, Davis I, Griffith WP, and Liu A* J. Am. Chem. Soc. 2020, 142(44), 18753-18757 (DOI: 10.1021/jacs.0c08992) Observing 3-hydroxyanthranilate-3,4-dioxygenase in action through a crystalline lens Wang Y, Liu KF, Yang Y, Davis I, and Liu A* Proc. Natl. Acad. Sci. U.S.A. 2020, 117(33), 19720-19730 (DOI: 10.1073/pnas.2005327117) (PNAS direct submission) Characterization of the non-heme iron center of cysteamine dioxygenase and its interaction with substrates Wang Y, Davis I, Yang Y, Chen Y, Naik SG, Griffith WP, and Liu A* J. Biol. Chem. 2020, 295(33), 11789-11802 (DOI: 10.1074/jbc.RA120.013915) Kinetic and spectroscopic characterization of the catalytic ternary complex of tryptophan 2,3-dioxygenase Geng J, Weitz AC, Dornevil K, Hendrich MP, and Liu A* Biochemistry 2020, 59(30), 2813-2822 (DOI: 10.1021/acs.biochem.0c00179) Carbon-fluorine bond cleavage mediated by metalloenzymes Wang Y and Liu A* Chem. Soc. Rev. 2020, 49, 4906-4925 (DOI: 10.1039/C9CS00740G) Substrate-assisted hydroxylation and O-demethylation in the peroxidase-like cytochrome P450 enzyme CYP121 Nguyen RC, Yang Y, Wang Y, Davis I, and Liu A* ACS Catalysis, 2020, 10(2) 1628-1639 (DOI: 10.1021/acscatal.9b04596) Crystal structures of L-DOPA dioxygenase from Streptomyces Sclerotialus Wang Y, Shin I, Fu Y, Colabroy KL, and Liu A* Biochemistry, 2019, 58(52), 5339-5350 (DOI: 10.1021/acs.biochem.9b00396) Quaternary structure of α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) controls its activity Yang Y, Davis I, Tsutomu M, Dmitri I, and Liu A* J. Biol. Chem. 2019, 294(30), 11609-11621 (DOI: 10.1074/jbc.RA119.009035) Biocatalytic carbon-hydrogen and carbon-fluorine bond hydroxylation promoted by a histidyl-ligated heme enzyme, LmbB2 Wang Y, Davis I, Shin I, Wherritt D, Griffith WP, Dornevil K, Colabroy KL, and Liu A* ACS Catalysis 2019, 9(6), 4764-4776 (DOI: 10.1021/acscatal.9b00231) Probing the Cys-Tyr cofactor biogenesis in cysteine dioxygenase by the genetic incorporation of fluorotyrosine Li J, Koto T, Davis I, and Liu A* Biochemistry 2019, 58(17), 2218-2227 (DOI: 10.1021/acs.biochem.9b00006 Cleavage of a carbon-fluorine bond by an engineered cysteine dioxygenase Li J, Griffith WP, Davis I, Shin I, Wang J, Li F, Wang Y, Wherritt D, and Liu A* Nat. Chem. Biol. 2018, 14(9), 853-860 (DOI: 10.1038/s41589-018-0085-5) Backbone dehydrogenation in pyrrole-based pincer ligands Krishnan VM, Davis I, Baker TM, Curran DJ, Arman H, Neidig ML, Liu A, and Tonzetich ZJ* Inorg. Chem. 2018, 57(15), 9544-9553 (DOI: 10.1038/s41589-018-0085-5) Adapting to oxygen: How 3-hydroxyanthrinilate 3,4-dioxygenase employs loop dynamics to accommodate substrates with disparate polarities Yang Y, Liu F,* and Liu A* J. Biol. Chem. 2018, 293(27), 10415-10424 (DOI: 10.1074/jbc.RA118.002698) Cofactor biogenesis in cysteamine dioxygenase: C-F bond cleavage with genetically incorporated unnatural tyrosine dioxygenase Wang Y, Griffith WP, Li J, Koto T, Wherritt D, Fritz E, and Liu A* Angew. Chem. Int. Ed., 2018, 57(27), 8149-8153 (DOI: 10.1002/ange.201803907) Reassignment of the human aldehyde dehydrogenase ALDH8A1 (ALDH12) to the kynurenine pathway in tryptophan catabolism Davis I, Yang Y, Wherritt D, and Liu A* J. Biol. Chem. 2018, 293(25), 9594-9603 (DOI: 10.1074/jbc.RA118.003320)