个人简介

Dr. Solmaz received her M.S. degree in Biochemistry from the Leibniz University of Hannover, Germany in 2001, and performed her M.S. thesis work with Nobel laureate Robert Huber, Ph.D., at the Max Planck Institute of Biochemistry in Martinsried, Germany. She received her Ph.D. degree in 2006 from the Goethe University in Frankfurt, Germany, for which she was a Ph.D. student with Nobel laureate Hartmut Michel, Ph.D. at the Max Planck Institute of Biophysics, supervised by Carola Hunte, Ph.D. As a Postdoctoral Researcher with Nobel laureate Gunter Blobel, Ph.D., at Howard Hughes Medical Institute at the Rockefeller University in New York, she has investigated the structure of the transport channel of the nuclear pore complex. Since fall 2014 she is an Assistant Professor in Biological Chemistry at Binghamton University.

研究领域

Biological Chemistry

Nuclear pore complexes are central gatekeepers of the cell nucleus, and facilitate selective transport of cargo between the cytoplasm and nucleus. As such, they regulate crucial cellular processes such as cell division, RNA metabolism and gene expression. We apply x-ray crystallography to visualize the protein components of this large macromolecular machinery at atomic resolution. Our interdisciplinary approach integrates methods of chemistry, physics, medicine and biology and will give insights into cancer formation, cell division and cell differentiation.

近期论文

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Solmaz, SR*, Blobel, G* and Melcak, I*. Ring cycle for dilating and constricting the nuclear pore, Proc Natl Acad Sci U S A, 2013, 110, 5858-5863**. Solmaz, SR, Chauhan, R, Blobel, G, and Melcak, I. Molecular architecture of the transport channel of the nuclear pore complex, Cell, 2011, 147, 590-602. Solmaz, SR, and Hunte, C. Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer, J Biol Chem, 2008, 283, 17542-17549. Hunte, C, Solmaz, S, Palsdottir, H, and Wenz, T. A structural perspective on mechanism and function of the cytochrome bc1 complex, Results Probl Cell Differ, 2008, 45, 253-278. Hunte, C, Solmaz, S, and Lange, C. Electron transfer between yeast cytochrome bc1 complex and cytochrome c: a structural analysis, Biochim Biophys Acta, 2002, 1555, 21-28.