个人简介

B.S., Chemistry, Davidson College, 1980 Ph.D., Biochemistry, Vanderbilt University, 1983

研究领域

Organic Chemistry, Biological Chemistry

My research interests are in Chemical Biology. Chemical Biology is a relatively new term used to describe the study of the chemistry that underlies all biological structure and processes. We use the principles, theories and tools that have been traditionally applied to small molecules and apply them to investigate biologically important systems. Consequently, we draw from diverse areas of chemistry and biology - ranging from computational chemistry to cell biology - to solve a biological problem.

近期论文

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"Dissecting paclitaxel-microtubule association: Quantitative assessment of the 2 '-OH group.” Sharma S, Lagisetti C, Poliks B, Coates RM, Kingston DGI, Bane S. 2013. Biochemistry 52, 2328-2336. “Site-specific fluorescent labeling of tubulin.” Mukherjee K, Bane SL. 2013. Methods in Cell Biology (Microtubules, In Vitro) 115, 1-12 “Measurement of in vitro microtubule polymerization by turbidity and fluorescence.” Mirigian M, Mukherjee K, Bane SL, Sackett DL. 2013. Methods in Cell Biology (Microtubules, In Vitro) 115, 215-229. “Aromatic Hydrazine-Based Fluorophores: Synthesis, Spectroscopy and Bioapplications.” Dilek O, Bane S. 2013. In Fluorophores: Characterization, Synthesis and Applications, ed. S Watanabe, pp. 53-76: Nova Science Publishers “Aurones: Small Molecule Visible Range Fluorescent Probes Suitable for Biomacromolecules.” Shanker N, Dilek O, Mukherjee K, McGee DW, Bane SL. 2011. Journal of Fluorescence 21, 2173-2184. “4-Aminophenylalanine as a biocompatible nucleophilic catalyst for hydrazone ligations at low temperature and neutral pH.” Blanden AR, Mukherjee K, Dilek O, Loew M, Bane SL. 2011. Bioconjugate Chemistry 22, 1954-1961. “Site-specific orthogonal labeling of the carboxy terminus of alpha-tubulin.” Banerjee A, Panosian TD, Mukherjee K, Ravindra R, Gal S, Sackett DL, Bane S. 2010. ACS Chemical Biology 5, 777-785. “Characterization of the Colchicine Binding Site on Avian Tubulin Isotype beta VI.” Sharma S, Poliks B, Chiauzzi C, Ravindra R, Blanden AR, Bane S. 2010. Biochemistry 49, 2932-2942. “Synthesis, biological activity and tubulin binding poses of 1-deoxy-9-(R)-dihydrotaxane analogs.” Yuan TH, Jiang Y, Wang XH, Wang DL, Bannerjee A, Bane S, Snyder JP, Lin HX. 2009. Bioorganic & Medicinal Chemistry Letters 19, 1148-1151. “Synthesis of boron dipyrromethene fluorescent probes for bioorthogonal labeling.” Dilek Ö, Bane SL. 2008. Tetrahedron Letters 49, 1413-1416. “Molecular Features of the Interaction of Colchicine and Related Structures with Tubulin.” Bane S. 2008. In The Role of Microtubules in Cell Biology, Neurobiology, and Oncology, ed. T Fojo, pp. 259-279: Humana Press “Design, synthesis and biological evaluation of bridged epothilone D analogues.” Chen QH, Ganesh T, Brodie P, Slebodnick C, Jiang Y, Banerjee A, Bane S, Snyder JP, Kingston DG. (2008) Organic and Biomolecular Chemistry 6, 4542-4552. [PubMed] “High-Throughput Screening of Microtubule-Interacting Drugs.” Bane SL, Ravindra R, Zaydman AA. 2007. In Microtubule Protocols, ed. J Zhou, pp. 281-288 “Enhanced microtubule binding and tubulin assembly properties of conformationally constrained paclitaxel derivatives.” Shanker N, Kingston DG, Ganesh T, Yang C, Alcaraz AA, Geballe MT, Banerjee A, McGee D, Snyder JP, Bane S. (2007) Biochemistry 46, 11514-11527. [PubMed] “Evaluation of the tubulin-bound paclitaxel conformation: synthesis, biology, and SAR studies of C-4 to C-3' bridged paclitaxel analogues.”Ganesh T, Yang C, Norris A, Glass T, Bane S, Ravindra R, Banerjee A, Metaferia B, Thomas SL, Giannakakou P, Alcaraz AA, Lakdawala AS, Snyder JP, Kingston DG. (2007) Journal of Medicinal Chemistry 50, 713-725. [PubMed] “Rotational-echo double-resonance NMR distance measurements for the tubulin-bound Paclitaxel conformation.” Paik Y, Yang C, Metaferia B, Tang S, Bane S, Ravindra R, Shanker N, Alcaraz AA, Johnson SA, Schaefer J, O'Connor RD, Cegelski L, Snyder JP, Kingston DG. (2007) Journal of the American Chemical Society 129, 361-70. [PubMed] “Promotion of tubulin assembly by poorly soluble taxol analogs.” Sharma S, Ganesh T, Kingston DG, Bane S. (2007) Analytical Biochemistry 360, 56-62.[PubMed] “Bridging converts a noncytotoxic nor-paclitaxel derivative to a cytotoxic analogue by constraining it to the T-Taxol conformation.” Tang S, Yang C, Brodie P, Bane S, Ravindra R, Sharma S, Jiang Y, Snyder JP, Kingston DG. (2006) Organic Letters 8, 3983-3986. [PubMed] “Design, synthesis, and bioactivity of simplified paclitaxel analogs based on the T-Taxol bioactive conformation.” Ganesh T, Norris A, Sharma S, Bane S, Alcaraz AA, Snyder JP, Kingston DG. (2006) Bioorganic and Medicinal Chemistry 14, 3447-3454. [PubMed] “The taxol pharmacophore and the T-taxol bridging principle.” Kingston DG, Bane S, Snyder JP. (2005) Cell Cycle 4, 279-289. Review. [PubMed]