个人简介

Dr. Reich received his Ph.D. from the University of California, San Francisco in 1984. After an NIH post-doctoral fellowship at UCSF, he joined the faculty at UCSB in 1987. His awards include: a Regent's Junior Faculty Fellowship (1987); an American Cancer Society Faculty Research Award (1991); and the UC President's Award for Excellence in Undergraduate Research (1994).

研究领域

Materials Chemistry/Biochemistry & Biophysics/Biomedical Sciences/Biology-Inspired Chemistry & Physics/Devices/Assembly & Nanochemistry/Structural Chemistry/Spectroscopy & Advanced Analysis

We are interested in the study of enzyme function, primarily at the levels of catalytic and specificity mechanisms, with a long term goal of developing enzyme inhibitors with potential therapeutic application. The current focus is on both bacterial and mammalian enzymes involved in the epigenetic process of DNA methylation and on telomerase. We also work on the development of new methods and technologies to investigate cell-biological, biochemical and biomedical questions.

近期论文

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Pollak, A.J., Reich, N.O. 2012. Proximal recognition sites facilitate intrasite hopping by DNA adenine methyltransferase: mechanistic exploration of epigenetic gene regulation. The Journal of biological chemistry, 287(27), 22873-81. Matje, D.M., Reich, N.O. 2012. Molecular drivers of base flipping during sequence-specific DNA methylation. Chembiochem : a European journal of chemical biology, 13(11), 1574-7. Laurence, T.A., Braun, G.B., Reich, N.O., Moskovits, M. 2012. Robust SERS enhancement factor statistics using rotational correlation spectroscopy. Nano letters, 12(6), 2912-7. Bonham, A.J., Wenta, N., Osslund, L.M., Prussin, A.J., 2nd, Vinkemeier, U., Reich, N.O. 2012. STAT1:DNA sequence-dependent binding modulation by phosphorylation, protein:protein interactions and small-molecule inhibition. Nucleic acids research. Cohn, E.P., Wu, K.L., Pettus, T.R., Reich, N.O. 2012. A new strategy for detection and development of tractable telomerase inhibitors. Journal of medicinal chemistry, 55(8), 3678-86. Holz-Schietinger, C., Matje, D.M., Reich, N.O. 2012. Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation. The Journal of biological chemistry, 287(37), 30941-51. Holz-Schietinger, C., Reich, N.O. 2012. RNA modulation of the human DNA methyltransferase 3A. Nucleic acids research, 40(17), 8550-7. Holz-Schietinger, C., Matje, D.M., Harrison, M.F., Reich, N.O. 2011. Oligomerization of DNMT3A controls the mechanism of de novo DNA methylation. The Journal of biological chemistry, 286(48), 41479-88. Matje, D.M., Coughlin, D.F., Connolly, B.A., Dahlquist, F.W., Reich, N.O. 2011. Determinants of precatalytic conformational transitions in the DNA cytosine methyltransferase M.HhaI. Biochemistry, 50(9), 1465-73. Menezes, S., Gaston, K.W., Krivos, K.L., Apolinario, E.E., Reich, N.O., Sowers, K.R., Limbach, P.A., Perona, J.J. 2011. Formation of m2G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14. Nucleic acids research, 39(17), 7641-55. Vallee-Belisle, A., Bonham, A.J., Reich, N.O., Ricci, F., Plaxco, K.W. 2011. Transcription factor beacons for the quantitative detection of DNA binding activity. Journal of the American Chemical Society, 133(35), 13836-9. Determinants of Precatalytic Conformational Transitions in the DNA Cytosine Methyltransferase M.HhaI, Matje DM, Coughlin DF, Connolly BA, Dahlquist FW, Reich NO. Biochemistry. 2011 Jan 13. [Epub ahead of print] The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L, Holz-Schietinger C, Reich NO. J Biol Chem. 2010 Sep 17;285(38):29091-100. Escherichia coli DNA adenine methyltransferase: intrasite processivity and substrate-induced dimerization and activation, Coffin SR, Reich NO., Biochemistry. 2009 Aug 11;48(31):7399-410. Laser-Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates, Braun GB, Pallaoro A, Wu G, Missirlis D, Zasadzinski JA, Tirrell M, Reich NO., ACS Nano. 2009 Jun 15. [Epub ahead of print]. Coupling sequence-specific recognition to DNA modification, Estabrook RA, Nguyen TT, Fera N, Reich NO., J Biol Chem. 2009 Aug 21;284(34):22690-6. Epub 2009 Jun 4. Tracking transcription factor complexes on DNA using total internal reflectance fluorescence protein binding microarrays, Bonham AJ, Neumann T, Tirrell M, Reich NO., Nucleic Acids Res. 2009 Jul;37(13):e94. Epub 2009 May 31.