List, Benjamin - Max-Planck-Institut für Kohlenforschung -

个人简介

Vita 2012 - 2014 Managing Director at the Max-Planck-Institut für Kohlenforschung since 2005 Director at the Max-Planck-Institut für Kohlenforschung since 2005 Scientific member of the Max-Planck-Society since 2004 Honorary Professor at the University of Cologne 2003 - 2005 Group Leader at the Max-Planck-Institut für Kohlenforschung 1999 - 2003 Assistant Professor (Tenure Track), Scripps Research Institute, La Jolla, USA 1997 PhD, University Frankfurt (J. Mulzer) 1993 Chemistry Diplom, Free University Berlin 1968 Born in Frankfurt/Germany Official Functions since 2022 Honorary Fellow of the Chinese Chemical Society since 2022 Professor at Hokkaido University, Graduate School of Chemical Sciences and Engineering since 2021 Specially Appointed Professor of Hokkaido University since 2018 Member of the German National Academy of Science Leopoldina since 2017 Advisory Council of the Institute for Molecular Science, Okazaki, Japan 2015 - 2023 Editor-in-Chief "Synlett", Thieme since 2011 Regional Editor "Synlett", Thieme since 2010 Member of the Editorial Advisory Panel "Nature Communications" since 2008 Member of the Editorial Advisory Board "Beilstein Journal of Organic Chemistry" since 2005 Editor "Synfacts", Thieme since 2010 Member of the Selection Committee „Heinrich-Wieland-Preis“ 2005 - 2011 Programme Coordinator of the DFG Priority Programme SPP1179 2008 - 2009 Editor: "Asymmetric Organocatalysis", Topics in Current Chemistry 2006 Editor: "Organocatalysis", Chemical Reviews 2004 Co-Editor, Special Edition: "Organocatalysis", Adv. Synth. Cat 2004 Co-Editor, Special Edition: "Enantioselective Organocatalysis, Accounts on Chemical Research"

研究领域

Our research aims towards the invention of new strategies for the development of “perfect chemical reactions” that combine quantitative yields and high atom economy, while avoiding toxic solvents, protecting group strategies, extreme temperatures, or inert gas atmosphere. We approach this ultimate goal by using selective catalysis based on small organic molecules. In recent years, it has been demonstrated that these organocatalysts can be as efficient and selective as the more commonly used metal-based catalysts, leading to a rapid growth of this field of research all around the globe. As a result of our ongoing investigations, our group was the first to demonstrate the concept of asymmetric counteranion-directed catalysis (ACDC) in 2005. Further investigations target the application of organocatalytic reactions in the synthesis of drugs and natural products. Aminocatalysis Brønsted-Acid-Catalysis Organic Lewis Acid Catalysis

近期论文

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Zheng, T.; Nöthling, N.; Wang, Z.; Mitschke, B.; Leutzsch, M.; List, B. A Solid Noncovalent Organic Double-Helix Framework Catalyzes Asymmetric [6 + 4] Cycloaddition. Science 2024, 385, 765–770. Luo, N.; Turberg, M.; Leutzsch, M.; Mitschke, B.; Brunen, S.; Wakchaure, V. N.; Nöthling, N.; Schelwies, M.; Pelzer, R.; List, B. The Catalytic Asymmetric Polyene Cyclization of Homofarnesol to Ambrox. Nature 2024. Han, J. T.; Tsuji, N.; Zhou, H.; Leutzsch, M.; List, B. Organocatalytic Asymmetric Synthesis of Si-Stereogenic Silacycles. Nature Communications 2024, 15, 5846. Guillén, M.; Liu, S.; Díaz-Oviedo, C. D.; Klussmann, M.; List, B. Acid-Catalyzed Oxy-Aminomethylation of Styrenes. ACS Catalysis 2024, 14, 751–756. Wakchaure, V. N.; DeSnoo, W.; Laconsay, C. J.; Leutzsch, M.; Tsuji, N.; Tantillo, D. J.; List, B. Catalytic Asymmetric Cationic Shifts of Aliphatic Hydrocarbons. Nature 2024, 625, 287–292. Han, J. T.; Zhou, H.; List, B. Brønsted Acid Catalyzed Asymmetric Silylation of Biaryl Diols. Synlett 2023, 34, 2393–2395. List, B. Enthusiasm, Guiding the Way to Universal Catalysts? Journal of Synthetic Organic Chemistry, Japan 2023, 81, 1019–1019. Singh, V. K.; Zhu, C.; De, C. K.; Leutzsch, M.; Baldinelli, L.; Mitra, R.; Bistoni, G.; List, B. Taming Secondary Benzylic Cations in Catalytic Asymmetric SN1 Reactions. Science 2023, 382, 325–329. Lindner, M. M.; Alachraf, M. W.; Mitschke, B.; Schulze, P.; Leutzsch, M.; List, B. Toward a Formyl-to-Phenyl Conversion: An Unexpected Photochemical Fulvene-Rearrangement. Angewandte Chemie International Edition 2023, 62, e202303119. Schwengers, S. A.; Gerosa, G. G.; Amatov, T.; Yasukawa, N.; Brunen, S.; Leutzsch, M.; Mitschke, B.; Shevchenko, G. A.; List, B. Direct Regioselective Dehydrogenation of α-Substituted Cyclic Ketones. Angewandte Chemie International Edition 2023, 62, e202307081. Li, S.; Zhou, H.; List, B. Synthesis and Resolution of an Axially Chiral Spirocyclic Quaternary Ammonium Ion-Based Phase-Transfer Catalyst. Asian Journal of Organic Chemistry 2023, 12, e202300241. Brunen, S.; Mitschke, B.; Leutzsch, M.; List, B. Asymmetric Catalytic Friedel–Crafts Reactions of Unactivated Arenes. Journal of the American Chemical Society 2023, 145, 15708–15713. Maji, R.; Ghosh, S.; Grossmann, O.; Zhang, P.; Leutzsch, M.; Tsuji, N.; List, B. A Catalytic Asymmetric Hydrolactonization. Journal of the American Chemical Society 2023, 145, 8788–8793. Grimm, J. A. A.; Zhou, H.; Properzi, R.; Leutzsch, M.; Bistoni, G.; Nienhaus, J.; List, B. Catalytic Asymmetric Synthesis of Cannabinoids and Menthol from Neral. Nature 2023, 615, 634–639. Zhou, H.; Properzi, R.; Leutzsch, M.; Belanzoni, P.; Bistoni, G.; Tsuji, N.; Han, J. T.; Zhu, C.; List, B. Organocatalytic DYKAT of Si-Stereogenic Silanes. Journal of the American Chemical Society 2023, 145, 4994–5000. Tsuji, N.; Sidorov, P.; Zhu, C.; Nagata, Y.; Gimadiev, T.; Varnek, A.; List, B. Predicting Highly Enantioselective Catalysts Using Tunable Fragment Descriptors. Angewandte Chemie International Edition 2023, 62, e202218659. Das, S.; Zhu, C.; Demirbas, D.; Bill, E.; De, C. K.; List, B. Asymmetric Counteranion-Directed Photoredox Catalysis. Science 2023, 379, 494–499. Scharf, M. J.; List, B. A Leap Forward in the Quest for General Catalysts. Nature 2022, 610, 632–633. Scharf, M. J.; List, B. A Catalytic Asymmetric Pictet–Spengler Platform as a Biomimetic Diversification Strategy Toward Naturally Occurring Alkaloids. Journal of the American Chemical Society 2022, 144, 15451–15456. Zhou, H.; Han, J. T.; Nöthling, N.; Lindner, M. M.; Jenniches, J.; Kühn, C.; Tsuji, N.; Zhang, L.; List, B. Organocatalytic Asymmetric Synthesis of Si-Stereogenic Silyl Ethers. Journal of the American Chemical Society 2022, 144, 10156–10161. Ouyang, J.; Maji, R.; Leutzsch, M.; Mitschke, B.; List, B. Design of an Organocatalytic Asymmetric (4 + 3) Cycloaddition of 2-Indolylalcohols with Dienolsilanes. Journal of the American Chemical Society 2022, 144, 8460–8466. Zhou, H.; Zhou, Y.; Bae, H. Y.; Leutzsch, M.; Li, Y.; De, C. K.; Cheng, G.-J.; List, B. Organocatalytic Stereoselective Cyanosilylation of Small Ketones. Nature 2022, 605, 84–89. Ghosh, S.; Erchinger, J. E.; Maji, R.; List, B. Catalytic Asymmetric Spirocyclizing Diels–Alder Reactions of Enones: Stereoselective Total and Formal Syntheses of α-Chamigrene, β-Chamigrene, Laurencenone C, Colletoic Acid, and Omphalic Acid. Journal of the American Chemical Society 2022, 144, 6703–6708. Obradors, C.; Mitschke, B.; Aukland, M. H.; Leutzsch, M.; Grossmann, O.; Brunen, S.; Schwengers, S. A.; List, B. Direct and Catalytic C-Glycosylation of Arenes: Expeditious Synthesis of the Remdesivir Nucleoside. Angewandte Chemie International Edition 2022, 61, e202114619. Zhou, H.; Properzi, R.; Leutzsch, M.; Belanzoni, P.; Bistoni, G.; Tsuji, N.; Han, J. T.; Zhu, C.; List, B. Organocatalytic DYKAT of Si-Stereogenic Silanes. Journal of the American Chemical Society 2022. Duan, M.; Díaz-Oviedo, C. D.; Zhou, Y.; Chen, X.; Yu , P.; List, B.; Houk, K. N.; Lan, Y. Chiral Phosphoric Acid Catalyzed Conversion of Epoxides into Thiiranes: Mechanism, Stereochemical Model, and New Catalyst Design. Angewandte Chemie International Edition 2022, 61, e202113204. Grossmann, O.; Maji, R.; Aukland, M. H.; Lee, S.; List, B. Catalytic Asymmetric Additions of Enol Silanes to in Situ Generated Cyclic, Aliphatic N-Acyliminium Ions. Angewandte Chemie International Edition 2022, 61, e202115036. Höfler, D.; Kaupmees, K.; Leito, I.; List, B. A Chiral Sulfoxide-Based C–H Acid. Synlett 2022, 33, 45–47. Höfler, D.; List, B. A Chiral, Dendralenic C–H Acid. Synlett 2022, 33, 38–39. Kennemur, J. L.; Maji, R.; Scharf, M. J.; List, B. Catalytic Asymmetric Hydroalkoxylation of C–C Multiple Bonds. Chemical Reviews 2021, 121, 14649–14681. Aukland, M. H.; List, B. Organocatalysis Emerging as a Technology. Pure and Applied Chemistry 2021, 93, 1371–1381. Díaz-Oviedo, C. D.; Maji, R.; List, B. The Catalytic Asymmetric Intermolecular Prins Reaction. Journal of the American Chemical Society 2021, 143, 20598–20604. Das, S.; Mitschke, B.; De, C. K.; Harden, I.; Bistoni, G.; List, B. Harnessing the Ambiphilicity of Silyl Nitronates in a Catalytic Asymmetric Approach to Aliphatic β3-Amino Acids. Nature Catalysis 2021, 4, 1043–1049. Zhou, H.; Zhang, P.; List, B. The Silicon–Hydrogen Exchange Reaction: Catalytic Kinetic Resolution of 2-Substituted Cyclic Ketones. Synlett 2021, 32, 1953–1956. Amatov, T.; Tsuji, N.; Maji, R.; Schreyer, L.; Zhou, H.; Leutzsch, M.; List, B. Confinement-Controlled, Either Syn- or Anti-Selective Catalytic Asymmetric Mukaiyama Aldolizations of Propionaldehyde Enolsilanes. Journal of the American Chemical Society 2021, 143, 14475–14481.