Donohoe, Timothy J. - University of Oxford

个人简介

I am currently Professor of Chemistry at the University of Oxford and a fellow of Magdalen College, Oxford. Our research lies in the field of asymmetric synthesis and the application of stereoselective oxidation and reduction reactions to natural product synthesis. We have a burgeoning interest in the area of carbohydrates and the application of metathesis to the synthesis of heterocycles. My group currently consists of four post doctoral researchers, eleven D.Phil. students and four Part II students. Curriculum Vitae Academic Titles d Positions 2006 – 2011 Head of Organic Chemistry, University of Oxford 2004 – present Professor of Chemistry, Magdalen College and the University of Oxford 2001 – 2004 Lecturer in Chemistry, Magdalen College and the University of Oxford 2000 – 2001 Reader in Chemistry, University of Manchester 1994 – 2000 Lecturer in Chemistry, University of Manchester Education 1993 – 1994 Post doctoral research with Prof. P. D. Magnus FRS on the synthesis of Taxol and its deoxy derivatives using an intramolecular pyrylium ylide cycloaddition approach, resulting in 5 publications. 1989 – 1992 D.Phil, Oxford University, under the supervision of Prof. S. G. Davies entitled Chiral Oxonium Ions, resulting in 5 publications. 1985 – 1989 BSc (Hons) first class, University of Bath. Final year project with Professor T. J. Gallagher entitled Ketenethioacetals as synthons for the synthesis of substituted aminoacids

研究领域

Our research interests lie in synthetic organic chemistry, and the contribution this science can make to the fields of medicine and natural products synthesis. We concentrate on developing new catalytic reactions and methodologies for synthetic organic chemistry and then employing our chemistry to make biologically important natural products. Our work is directly relevant to the pharmaceutical industry and the research group is supported by many multi-national companies including AstraZeneca, GlaxoSmithKline, Lilly, Novartis and Pfizer.

近期论文

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Stereoselective synthesis of cyclohexanes via an iridium catalysed (5+1) annulation strategy. Wasim M. Akhtar, Roly J. Armstrong, James R. Frost, N. G. Stevenson, Timothy J. Donohoe. J. Am. Chem. Soc., 2018, 140, 11916-11920. DOI: 10.1021/jacs.8b07776 OBO-protected pyruvates as reagents for the synthesis of functionalized heteroaromatic compounds. C. Henrique Alves Estavez, Maria Koyioni, Kirsten E. Christensen, Peter D. Smith, Timothy J. Donohoe, Organic Letters, 2018, 20, 4048-4051. DOI: 10.1021/acs.orglett.8b01614 Asymmetric Total Synthesis of (-)-(3R)-Inthomycin C. Sandra Balcells, Maxwell B. Haughey, Johannes C. L. Walker, Laia Josa-Cullere, Christopher Towers, Timothy J. Donohoe, Organic Letters, 2018, 20, 3583-3586. DOI: 10.1021/acs.orglett.8b01370 The efficacy of the quercetin analogue LY294002 in immortalized cancer cell lines is related to the oxygenic and metabolic status of cells. Xinyue Huang, Michelle Potter, Ben Pilgrim, Ruchuta Ardkhean, Mikail Kabeshov, Timothy Claridge, Matthew Wiseman, Karl Jonathan Morten, Timothy Donohoe, Helen Elizabeth Townley. Int. J. Cancer Ther. Oncol., 2017, 5, 51X. DOI: 10.14319/ijcto.51.14 Cobalt versus osmium: control of both trans and cis selectivity in construction of the EFG rings of pectenotoxin 4. Ahria Roushanbakhti, Yifan Liu, Paul C. M. Winship, Michael J. Tucker, Wasim M. Akhtar, Daryl S. Walter, Gail Wrigley and Timothy J. Donohoe. Angewandte Chemie Int. Ed., 2017, 56, 14883-14887. DOI: 10.1002/anie.201708278 Hexafluoroisopropanol as a highly versatile solvent. Ignacio Colomer, Anna E. R. Chamberlain, Maxwell B. Haughey and Timothy J. Donohoe. Nature Reviews Chemistry, 2017, 1, 0088. DOI: 10.1038/s41570-017-0088 Pyruvate Enolate Arylation and Alkylation: OBO Ester Protected Pyruvates as Useful Reagents in Organic Synthesis. Carlos Henrique Esteves, Christopher Hall, Peter Smith and Timothy J. Donohoe. Organic Letters, 2017, 19, 5248-5251. DOI: 10.1021/acs.orglett.7b02524 Catalytic enolate arylation with 3-bromoindoles allows the formation of beta-carbolines. C. Henrique Estavez Alves, Peter D. Smith, and Timothy J. Donohoe. J. Org. Chem. 2017, 82, 4435-4443. DOI: 10.1021/acs.joc.7b00299 Hydrogen Borrowing Catalysis with Secondary Alcohols: A New Route for the Generation of β-Branched Carbonyl Compounds. Wasim M. Akhtar, Choon Boon Cheong, James R. Frost, Kirsten E. Christensen, Neil G. Stevenson, and Timothy J. Donohoe. J. Am. Chem. Soc., 2017, 139, 2577-2580. DOI: 10.1021/jacs.6b12840 Diastereoselective synthesis of the 5-hydroxy-pyrrolidinone amino acid of the microsclerodermins and model studies for an end-game strategy for microsclerodermin B. Christian Winter, Robert D. C. Pullin and Timothy J. Donohoe. Tetrahedron Letters, 2017, 58, 602-605. DOI: 10.1016/j.tetlet.2016.12.045 Orthogonally protected 1,2 diols from electron-rich alkenes using metal free olefin syn dihydroxylation. Ignacio Colomer, Rosimeire Coura Barcelos, Kirsten E. Christensen, Timothy J. Donohoe. Organic Letters, 2016, 18, 5880-5883. DOI: 10.1021/acs.orglett.6b02959 Dehydromicrosclerodermin B and microsclerodermin J: total synthesis and structural revision Ekaterina Y. Melikhova, Robert D. C. Pullin, Christian Winter, Timothy J. Donohoe. Angewandte Chemie Int. Ed., 2016, 55, 9753-9757. DOI: 10.1002/ange.201604764 Hydrogen bonding to hexafluoroisopropanol controls the oxidative strength of hypervalent iodine reagents. Ignacio Colomer, Christopher Batchelor-McAuley, Barbara Odell, Timothy J. Donohoe, Richard Compton. J. Am. Chem. Soc. 2016,138, 8855-8861. DOI: 10.1021/jacs.6b04057 Iridium-Catalyzed C4-Alkylation of 2,6-Di-tert-butylphenol using Hydrogen Borrowing Catalysis. James R. Frost, Choon Boon Cheong, Timothy J. Donohoe. Synthesis, 2016, 49, 910-916. DOI: 10.1055/s-0035-1561439 Synthesis of aromatic heterocycles using ring-closing metathesis. Harish K. Potukuchi, Ignacio Colomer, Timothy J. Donohoe. Advances in Heterocyclic Chemistry: Alan Katritzky Tribute volume, Chapter 15, 2016, Elsevier, 43-65. DOI: 10.1016/bs.aihch.2016.04.006 Catalytic hypervalent iodine promoters allow styrene dimerisation and the formation of tri- and tetrasubstituted cyclobutanes. Ignacio Colomer, Rosimeire Coura Barcelos and Timothy J. Donohoe. Angewandte Chemie Int. Ed., 2016, 55, 4748-4752. DOI: 10.1002/anie.201511683 Palladium-catalysed enolate arylation as a key C-C bond forming reaction for the synthesis of isoquinolines. Ben S. Pilgrim, Alice E. Gatland, Carlos H. A. Estaves, Charlie T. McTernan, Geraint R. Jones, Matthew R. Tatton, Panayiotis A. Procopiou, Timothy J. Donohoe. Organic and Biomolecular Chemistry, 2016, 14, 1065-1090. Designated as a HOT article. DOI: 10.1039/C5OB02320C Strategic application and transformation of ortho-di-substituted phenyl and cyclopropyl ketones to expand the scope of hydrogen borrowing catalysis. James R. Frost, Choon Boon Cheong, Wasim M. Akhtar, Dimitri F. J. Caputo, Neil G. Stevenson and Timothy J. Donohoe. J. Am. Chem. Soc. 2016, 137, 15664-15667. DOI: 10.1021/jacs.5b11196 Application of catalytic Z-selective olefin metathesis in natural product synthesis. Simon Werrel, Johannes C. L. Walker and Timothy J. Donohoe. Tetrahedron Letters, 2015, 56, 5261-5268. DOI: 10.1016/j.tetlet.2015.07.008 Aziridine electrophiles in the functionalisation of peptide chains with amine nucleophiles. Anatol P. Spork and Timothy J. Donohoe. Organic and Biomolecular Chemistry, 2015, 13, 8545-8549. DOI: 10.1039/C5OB00856E