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个人简介

现任中国药科大学校学术委员会副主任、校学位委员会副主席;江苏省药物分子设计与成药性优化重点实验室主任,天然药物活性组分与药效国家重点实验室天然活性物质成药性研究方向负责人,江苏省“青蓝工程”科技创新团队负责人 社会兼职:担任国家药典委员会执行委员;中国药学会理事、药物化学专业委员会委员;江苏省药学会副秘书长、常务理事、药物化学专业委员会主任委员;教育部实验教学指导委员会委员;国际药学联合会规划委员会委员,亚洲药学院校理事会理事。此外还担任《中国药科大学学报》副主编,《药学学报》、《中国药物化学杂志》等13本杂志的编委等职务;担任SCI杂志:Journal of Medcinal Chemistry编委;担任外文期刊:Chinese Journal of Pharmaceutical Sciences, Inter J Med Chem, Orphan Drugs: Research and Reviews等国际杂志的编委;担任Journal of Medicinal Chemistry, PloS ONE, Current Medicinal Chemistry, European Journal of Medicinal Chemistry, Bioorganic Medicinal Chemistry, Bioorganic Medicinal Chemistry Letter等著名国际学术杂志特约审稿人

研究领域

新药分子设计与合成研究 尤启冬教授主要从事药物分子设计与合成、药物作用的分子机制和新药研究等方向的工作,在活性天然产物的结构改造与优化、“蛋白-蛋白”相互作用调控剂、重大疾病关键调控节点的评价及药物设计等方面开展了多年研究

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update. Lu MC, Ji JA, Jiang ZY, You QD. Med Res Rev. 2016 May 18. doi: 10.1002/med.21396. Palladium(II)-Catalyzed C-H Bond Activation/C-C Coupling/Intramolecular Tsuji-Trost Reaction Cascade: Facile Access to 2H-Pyranonaphthoquinones. Bian, Jinlei; Qian, Xue; Wang, Nan; Mu, Tong; Li, Xiang; Sun, Haopeng; Zhang, Lianshan; You, Qidong; Zhang, Xiaojin. Org Lett. 2015, 17 (14):3410–3413. Design, Synthesis, and Initial Evaluation of Affinity-based Small-Molecule Probes for Fluorescent Visualization and Specific Detection of Keap1. Mengchen Lu, Hai-shan Zhou, Qi-Dong You, and Zhengyu Jiang. J. Med. Chem., Just Accepted Manuscript • DOI: 10.1021/acs.jmedchem.6b00775 Structure-Activity and Structure-Property Relationship and Exploratory in vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor.Zhengyu Jiang, Lili Xu, Mengchen Lu, Zhiyun Chen, Zhenwei Yuan, Xiaoli Xu, Xiaoke Guo, Xiaojin Zhang, Haopeng Sun, Qi-Dong You.J. Med. Chem.,2015, 58 (16):6410–6421 Discovery and Modification of in vivo active Nrf2 Activators with 1, 2, 4-oxadiazole Core: Hits Identification and Structure-Activity Relationship Study. Xu, Lili; Zhu, Junfeng; Xu, Xiaoli; Zhu, Jie; Li, Li; Xi, Meiyang; Jiang, Zhengyu; Zhang, Mingye; Liu, Fang; Lu, Mengchen; Bao, Qichao; Zhang, Chao; Wei, Jinlian; Zhang, Xiaojin; You, Qi-Dong; Sun, Haopeng. J Med Chem. 2015, 58 (14), pp 5419–5436 Discovery of potent Keap1-Nrf2 Protein-Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis. Jiang Z, Lu M, Xu L, Yang T, Xi M, Xu X, Guo X, Zhang X, You Q*, Sun H*. J Med Chem. 2014, 57:2736-2745 3-Aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as Potent Nrf2/ARE Inducers in Human Cancer Cells and AOM-DSS Treated Mice. Mei-yang Xi, Jian-min Jia, Hao-peng Sun*, Zhong-ying Sun, Jie-wei Jiang, Ya-jing Wang, Min-ye Zhang, Jun-feng Zhu, Li-li Xu, Zheng-yu Jiang, Xin Xue, Ming Ye, Xi Yang, Yuan Gao, Lei Tao, Xiao-ke Guo, Xiao-li Xu, Qing-long Guo, Xiao-jin Zhang, Rong Hu*, and Qi-dong You*. J Med Chem. 2013, 56(20),7925–7938 Garcinia Xanthones as Orally Active Antitumor Agents. Zhang X, Li X, Sun H, Wang X, Zhao L, Gao Y, Liu X, Zhang S, Wang Y, Yang Y, Su Z, Guo Q, You Q*.J Med Chem. 2013, 56(1), 276-292 Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: Introduction of an additional carboxyl group at the C-2 position of quinoline. Feng T, Li D, Wang H, Zhuang J, Liu F, Bao Q, Lei Y, Chen W, Zhang X, Xu X, Sun H, You Q, Guo X.Eur J Med Chem. 2015, 105:145-155. An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis. Meng-Chen Lu, Jian-Ai Ji, Yong-Lin Jiang, Zhi-Yun Chen, Zhen-Wei Yuan, Qi-Dong You & Zheng-Yu Jiang. Scientific Reports 2016, 6:26585

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