个人简介
Lutz Ackermann studied Chemistry at the University Kiel (Germany), and performed his PhD with Prof. Alois Fürstner at the Max-PlankInstitut für Kohlenforschung (Mülheim/Ruhr, 2001). After a postdoctoral stay at UC Berkeley with Prof. Robert G. Bergman, he initiated his independent research career in 2003 at the Ludwig Maximilians-University München. In 2007, he became Full Professor (W3) at the Georg-August-University Göttingen. His recent awards and distinctions include an AstraZeneca Excellence in Chemistry Award (2011), an ERC Consolidator Grant (2012), a Gottfried-Wilhelm-Leibniz-Preis (2017) and an ERC Advanced Grant (2021).
Education and Research Experience
since 2019 Founder and Director of the Woehler Research Institute for Sustainable Chemistry: WISCh
since 2017 PI at German Centre for Cardiovascular Research (DZHK)
2015-2017 Director of the Institute of Organic and Biomolecular Chemistry
2013-2015 Dean of Research, Faculty of Chemistry, Georg-August-University Göttingen
2015-2019 Adjunct Professor at the Università di Pavia
2011-2013 Dean of the Faculty of Chemistry, Georg-August-University Göttingen
since 05.2007 Chair and Full Professor (W3) at the Georg-August-University Göttingen
06.2003-04.2007 Assistant Professor, Emmy Noether-Fellow (DFG): Independent research at the LMU München (Prof. Dr. P. Knochel)
07.2001-05.2003 Postdoctoral Studies with Prof. Dr. R. G. Bergman, UC Berkeley
06.1998-06.2001 Ph.D. thesis (Mentor: Prof. Dr. A. Fuerstner), Max-Planck-Institut für Kohlenforschung in Muelheim/Ruhr (summa cum laude)
08-12.1999 Research stay at the Université de Rennes, France (Prof. Dr. P. H. Dixneuf)
08.1997-03.1998 Diploma thesis (MSc) (Prof. Dr. J. Mattay)
10.1993-03.1998 Studies of Chemistry at the Christian-Albrechts-Universität zu Kiel
近期论文
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Y. Zhang, C. Zhao, C. Ma, Z. Cai, S. Trienes, L. Ackermann, "Photocatalytic C–C Cleavage of Methylenecyclobutanes for γ,δ-Unsaturated Aldehydes by Strain Release" Angew. Chem. Int. Ed. 2023, 62, in press. Abstract>
X. Chen, H. C. Gülen, J. Wu, Z.-J. Zhang, X. Hong, L. Ackermann, "Close-Shell Reductive Elimination versus Open-Shell Radical Coupling for Site-Selective Ruthenium-Catalyzed C–H Activations by Computation and Experiments" Angew. Chem. Int. Ed. 2023, 62, in press. Abstract>
J.-B. Liu, X.-J. Liu, J. C. A. Oliveira, D.-Z. Chen, L. Ackermann, "Cobalt-catalyzed radical-mediated carbon-carbon scission via a radical-type migratory insertion" Chem. Sci. 2023, 14, in press. Abstract>
J. Wu, W. Wei, J. Pöhlmann, R. Purushothaman, L. Ackermann, "Domino meta-C−H Ethyl Glycosylation by Ruthenium(II/III) Catalysis: Modular Assembly of meta-C-Alkyl Glycosides" Angew. Chem. Int. Ed. 2023, 62, in press. Abstract>
D. Wang, B. Yuan, J. Xu, L. Ackermann, "Electrochemical Rearrangement for Remote Functionalizations of Unactivated Alkenes" Chem. Eur. J. 2023, 28, in press. Abstract>
Y. Zhang, Z. Cai, C. Zhao, H. Zheng, L. Ackermann, "Electrosynthesis of Bridged or Fused Sulfonamides through Complex Radical Cascade Reactions: Divergence in Medium-Sized Ring Formation" Chem. Sci. 2023, 14, in press. Abstract>
L.-C. Xu, J. Frey, X. Hou, S.-Q. Zhang, Y.-Y. Li, J. C. A. Oliveira, S.-W. Li, L. Ackermann, X. Hong, "Enantioselectivity prediction of pallada-electrocatalysed C–H activation using transition state knowledge in machine learning" Nature Synthesis 2023, in press. DOI:10.1038/s44160-022-00233-y. Abstract>
K. Zeng, R. Mei, S. Dechert, L. Ackermann, K. Zhang, "A recyclable stereoauxiliary aminocatalyzed strategy for one-pot synthesis of indolizine-2-carbaldehydes" Commun. Chem. 2023, 6, 40. Abstract>
T. von Münchow, S. Dana, Y. Xu, B. Yuan, L. Ackermann, "Enantioselective electrochemical cobalt-catalyzed aryl C–H activation reactions" Science 2023, 379, 1036–1042. Abstract>
N. Kaplaneris, A. Puet, F. Kallert, J. Pöhlmann, L. Ackermann, "Late-stage C–H Functionalization of Tryptophan-containing Peptides with Thianthrenium Salts: Conjugation and Ligation" Angew. Chem. Int. Ed. 2023, 62, e20221666. Abstract>
J. Struwe, L. Ackermann, F. Gallou, "Recent Progress in Copper-free Sonogashira-Hagihara Cross-Couplings in Water" Chem. Catal. 2023, 3, 100485. Abstract>
S. Cattani, A. Secchi, L. Ackermann, G. Cera, "Triazole-enabled, iron-catalysed linear/branched selective C−H alkylations with alkenes" Org. Biomol. Chem. 2023, 21, 1264-1269. Abstract>
Y. Zhang, Z. Cai, S. Warratz, C. Ma, L. Ackermann, "Recent Advances in Electrooxidative Radical Transformations of Alkynes" Sci. China Chem. 2023, 66, 703-724. Abstract>
S.-Q. Zhang, L.-C. Xu, S.-W. Li, J. C. A. Oliveira, X. Li, L. Ackermann, X. Hong, "Bridging Chemical Knowledge and Machine Learning for Performance Prediction of Organic Synthesis" Chem. Eur. J. 2023, 28, e202202834. Abstract>
Zhipeng Lin,' U. Dhawa,' B. Yuan, Y.-C. Liou, M. J. Johansson, L. Ackermann, "Electrocatalyzed Direct Arene Alkenylations without Directing Groups: Selective Late-Stage Drug Diversification" Research Square 2022, https://doi.org/10.21203/rs.3.rs-1607467/v1. ' These authors contributed equally. Abstract>
J. Wegener, G. Mitronova, C. Quentin, G. Hasenfuss, L. Ackermann, S. Lehnart, "Development and analysis of novel small-molecule RyR2 compounds on RyR2 and SERCA2a activity in living permeabilized cardiomyocytes" J. Mol. Cell. Cardiol., 2022, 173, 88. Abstract>
Y. Li, Y.-C. Liou, J. C. A. Oliveira, L. Ackermann, "Ruthenium(II)/Imidazolidine Carboxylic Acid-Catalyzed C−H Alkylation for Central and Axial Double Enantio-Induction" Angew. Chem. Int. Ed. 2022, 61, e202212595. Abstract>
R. Zhao, Z. Lin, I. Maksso, J. Struwe, L. Ackermann, "Electrochemical Cross-Electrophile-Coupling for Transition-Metal-Free Allylic Carboxylation with Ambient CO2" ChemElectroChem 2022, 9, e202200989. Abstract>
J. Wu, N. Kaplaneris, J. Pöhlmann, T. Michiyuki, B. Yuan, L. Ackermann, "Remote C–H Glycosylation by Ruthenium(II) Catalysis: Modular Assembly of meta-C-Aryl Glycosides" Angew. Chem. Int. Ed. 2022, 61, e202208620. Abstract>
J. C. A. Oliveira, J. Frey S.-Q. Zhang, L.-C. Xu, X. Li, S.‑W. Li, X. Hong, L. Ackermann, "When machine learning meets molecular synthesis" Trends Chem. 2022, 4, 863-885. Abstract>