Kim, Sung - University of Western Ontario - Department of Microbiology and Immunology

个人简介

Education: B.Sc. (Pharm.), University of Manitoba, Winnipeg, MB Ph.D., Department of Pharmacology and Toxicology, Faculty of PharmceuticalSciences, University of British Columbia, Vancouver, BC Training: Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA Faculty of Experimental Medicine, Univeristy of British Columbia, BC Awards: Early Research Award, 2007-2011 CIHR New Investigator Award, 2005-2010 CIHR Post-doctoral Fellowship, 1999-2002 MRC Studentship, 1992-1997 Canadian Heart and Stroke Studentship, 1992 Wyeth Award for Excellence, Faculty of Pharmacy, University of Manitoba, 1992 PMAC/MRC Undergraduate Research Scholarship, 1991 United Pharmacists Wholesale Manitoba Ltd. Scholarship, 1991 Appointments: Associate Professor, Microbiology & Immunology, University of Western Ontario Scientist, Lawson Health Research Institute

近期论文

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Ha S-D., Meshkibaf S., Reid C., Kim S.O.*: Inhibition of IL-1β expression by anthrax lethal toxin is reversed by HDAC8 inhibition in murine macrophages. J Biol Chem (2016, Feb). PMID: 26912657. Meshkibaf S., Martin A., Kim S.O.*: Protective role of G-CSF in dextran sulfate sodium-induced acute colitis through generating gut-homing immune regulatory macrophages. Cytokine 2016 Feb 78:69-78. PMID: 26687628 Meshkibaf S., Fritz J., Gottschalk M., Kim S.O.: Preferential production of G-CSF by a protein-like Lactobacillus rhamnosus GR-1 secretory factor through activating TLR2-dependent signaling events without activation of JNKs. BMC Microbiol. 2015 Oct 26;15(1):238. PMID: 26502905. Yang S., Reid G., Challis J.R.G., Kim S.O., Gloor G.B., Bocking A.D.: Is there a role for probiotics in the prevention of preterm birth? Frontiers in Immunology: Review 6:62. doi: 10.3389/fimmu.2015.00062. eCollection (2015). PMID: 25741339 HDAC8-mediated epigenetic reprogramming plays a key role in resistance to anthrax lethal toxin-induced pyroptosis in macrophages. Journal of Immunology 193(3):1333-43 (2014) PMID: 24973453. Meshkibaf S., Gower M., Dekaban G., Kim S.O.*: G-CSF preferentially supports the generation of gut-homing Gr-1high macrophages in M-CSF-treated bone marrow cells. Journal of Leukocyte Biology 96(4):549-61 (2014). PMID: 24981628. Yang S., Li W., Challis J., Reid G., Kim S.O., Bocking A. . Probiotic Lactobacillus rhamnosus GR-1 supernatant prevents lipopolysaccharide-induced preterm birth and reduces inflammation in pregnant CD-1 mice. American Journal of Obstetrics & Gynecology 211(1):44e1-44e12 (2014). PMID: 24486224. Li W., Yang S., Kim SO., Reid G., Challis JR., Bocking AD: Lipopolysaccharide-Induced Profiles of Cytokine, Chemokine, and Growth Factors Produced by Human Decidual Cells Are Altered by Lactobacillus rhamnosus GR-1 Supernatant. Reproductive Sci. 21(7):939-947 (2014). PMID:24429676. Park S., Ha SD., Coleman M., Meshkibaf S., Kim S.O.*: p62/SQSTM1 enhances NOD2-mediated signaling and cytokine production through stabilizing NOD2 oligomers. PLoS ONE 8(2): e57138 (2013). Ha SD., Park S., Han CY., Nguyen ML., Kim S.O.*: Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and ROS generation through down-regulating MLN64 in macrophages. Mol. Cell. Biol. (2012). PMID: 23028046 Ha S-D., Park S.W., Hattlmann C., Barr S.D., Kim S.O.*: Inhibition or deficiency of cathepsin B leads defects in HIV-1 Gag pseudoparticle release in macrophages and HEK293T cells. Antiviral Res 93(1): 175-184 (2012). PMID: 22138708 Lee S., Wang Y., Kim S.O., Han J.: AMPD3 is involved in anthrax LeTx-induced macrophage cell death. Protein Cell 2(7):564-572 (2011). PMID: 21822801 Martins A., Spanton S., Sheikh H.I., Kim S.O.*: The anti-inflammatory role of granulocyte-colony stimulating factor in macrophage-dendritic cell crosstalk after Lactobacillus rhamnosus GR-1-exposure. Journal of Leukocyte Biology 89(6):907-915 (2011). PMID: 21385950. Ha S-D., Ham B., Morgridge J., Saftig P., Lin S., Kim S.O.: Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm. J Biol Chem 285(3):2120-9 (2010). PMID: 19858192. Ono K., Wang X., Kim SO., Armstrong LC., Bornstein P., Han J.: Metaxin deficiency alters mitochondrial membrane permeability and leads to resistance to TNF-induced cell killing. Protein Cell 1(2): 161-173 (2010). PMID: 21088703. Martins A., Colqhoun P., Reid G., Kim S.O.*: Reduced expression of basal and probiotic-inducible G-CSF in intestinal mononuclear cells is associated with inflammatory bowel disease. Inflammatory Bowel Diseases 15(4):515-25 (2009). PMID: 19058228. *corresponding author. Selected as recommended reading for Faculty of 1000 Biology (http://www.f1000biology.com/article/id/1139083). Yeganegi M., Watson C.S., Martins A., Kim S.O., Reid G., Challis J.R.G., Bocking A.D.: Effect of Lactobacilli Supernatant and Fetal Sex on LPS-Induced Cytokines and Prostaglandin-Regulating Enzymes in Human Placental Trophoblasts: Implications for Treatment of Bacterial Vaginosis and Prevention of Preterm Labour. Amercian Journal of Obstetrics and Gynecology 200(5):532.e1-8 (2009). PMID: 19285652. Co-author: contributed in concept and experimental approach development of the study, provided reagents and input in writing manuscript. Ha S-D., Martins A., Khazaie K., Han J., Kim S.O.*:Cathepsin B is involved in the post-translational processing of tumor necrosis factor-α in lipopolysaccharide-activated macrophages. J. Immunology 181(1):690-697 (2008). PMID: 18566436. Ha S-D.§, Ng D.§, Pelech S., Kim S.O.*: Critical role of PI3-K/AKT/GSK-3β signaling pathway in recovery from anthrax lethal toxin-induced cell cycle arrest and MEK cleavage in human monocytic cell lines. J Biol Chem. 282(50):36230-36239 (2007). PMID: 17951252. §Equal contribution. *Selected as recommended reading for Faculty of 1000 Biology (http://www.f1000biology.com/article/id/1093935). Ha S-D., Ng D., Lamoth J., Valvano M., Han J., Kim, S.O.*: Down-regulation BNIP3 and BNIP3L through inactivation of p38 is the mechanism for the anthrax lethal toxin-induces resistance in macrophages. J. of Biol Chem 282(36):26275-26283 (2007. Sept). PMID: 17623653. Kang Y.J., Kim S.O., Shimada S., Otsuka M., Watts T., Han J. : 4-1BBL signaling in LPS-activated macrophages is required for sustained TNF production. Nature Immunol. 8(6):601-9 (2007). PMID: 17496895. Kim S.O.*, Ha S-D, Lee S., Stanton S., Beutler B., Han J.: Mutagenesis by Retroviral Insertion in Chemical Mutagen-Generated Quasi-Haploid Mammalian Cells. BioTechnique 42 (4):493-501(2007). *corresponding author; S-D Ha is a postdoctoral fellow under my supervision. PMID: 17489237. Song L., Li J., Ye J., Yu G., Ding J., Zhang D., Ouyang W., Dong J., Kim S.O., Huang C.: p85α acts as a novel signal transducer specifically for cell apoptotic response to UV Radiation. Mol. Cell. Biol. 27(7): 2713-2731 (2007). PMID:17242187. Kim S.O.*, Sheikh H.I., Ha S-D., Martins A., Reid G.: G-CSF-mediated inhibition of JNK is a key mechanism for Lactobaci llus rhamnosus-induced anti-inflammatory effects in macrophages. Cell. Microbiol. 8(12):1958-1971 (2006). PMID: 16889627 Xu Y., Kim SO., Li Y., Han J.: Autophagy contributes to caspase-independent macrophage cell death. J. Biol. Chem. 281: 19179-19187 (2006). PMID: 16702227.