Wan, Wankei - University of Western Ontario - Department of Chemical and Biochemical Engineering

个人简介

Current Positions Professor - Department of Chemical and Biochemical Engineering Professor - School of Biomedical Engineering Associate Scientist - Robarts Research Institute Associate Scientist - Lawson Health Research Institute Past Positions 2000 – 2007 Director, Graduate Program in Biomedical Engineering 1980 – 1992 Research Scientist, Esso Research Canada / Exxon Research and Engineering Company Dr. Wan's research interests lie in the general area of biomaterials, nanomaterials and medical devices. Specific areas of current interest include development of degradable and non-degradable biomaterials for tissue regeneration with applications for cardiovascular devices, novel wound dressings and therapeutic delivery systems.

研究领域

The focus of our research group is to design and synthesize, discover, modify and adapt biocompatabile materials for biomedical applications. These include synthetic and natural biomaterials and nano-biomaterials including proteins and polysaccharides. Biomaterials Bacterial cellulose, a natural nano-biomaterial produced via microbial fermentation with a primary fibril diameter of ~15 nm Collagen, an important matrix protein that is present in the human body Poly(vinyl alcohol), a synthetic hydrogel material Poly(amic acid), a novel composition that is cell compatible Composite biomaterials Biomaterial processing Electrospinning and centrifugal spinning for nano- and micro- fibers Microfluidics techniques and electrospraying for microbeads Compression molding Solution film casting Biomedical applications Implantable devices for the cardiovascular and auditory systems Novel wound dressings that promote wound healing and control wound infection in chronic and diabetic wounds Nanofibrous scaffolds of controlled geometry and fiber orientation for tissue regeneration Delivery systems for therapeutics that can deliver drugs, peptides, proteins, genes and nucleic acids Multifunctional bioactive devices that incorporate the controlled release/drug delivery function to promote the desired clinical outcomes (e.g. drug eluting coronary stent) Green Process and Biomaterials The focus of this research area is to explore the production of useful natural materials and in particular, those relevant to biomedical and health related applications. The processes used should be environmentally friendly in terms of CO2 emission and carbon utilization. This criterion should also be applied to the subsequent separation and purification steps. Our main focuses are bacterial cellulose, a nanobiomaterial, produced by microbial fermentation and the use of microalgae/cyanobacteria in photochemical processes utilizing CO2 as the carbon source to produce algal oil for biofuels, natural and degradable polymers and astaxanthin, a potent natural antioxidant that is a FDA approved dietary ingredient. For more information on my research in this area, please see my Green Process and Biomaterials page.

近期论文

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Wankei Wan, A. Dawn Bannerman, Lifang Yang, and Helium Mak, “Poly(vinyl Alcohol) Cryogels for Biomedical Applications” Advances in Polymer Science 263: 283-321 (2014) Suanne Mahabir; Darcy Small; Ming Li; Wankei Wan; Norbert Kucerka; Kenneth Littrell; John Katsaras; Mu-Ping Nieh, “Growth Kinetics of Lipid-Based Nanodiscs to Unilamellar Vesicles - A Time-Resolved Small Angle Neutron Scattering (SANS) Study” Biochimica et Biophysica Acta – Biomembranes 1828: 1025–1035 (2013) Leonardo E. Millon, Donna T. Padavan, Amanda Hamilton, Derek Boughner, Wankei Wan, “Exploring Cell Compatibility of a Fibronectin Functionalized Poly(vinyl Alcohol) Hydrogel” Journal of Biomedical Materials Research 100B (1): 1-10 (2012) Darcy Small, Norm Huner, Wankei Wan, “Effect of Static Magnetic Fields on the Growth, Photosynthesis and Ultrastructure of Chlorella Kessleri” Bioelectromagnetics 33(4): 298-308 (2012) Ian M. Power, Siobhan A. Wilson, Darcy Small, Gregory M. Dipple, Wankei Wan, and Gordon Southam, “Microbially Mediated Mineral Carbonation: Roles of Phototrophy and Heterotrophy” Environ. Sci. Technol. 45: 9061-9068 (2012) Xiaobo Zeng, Darcy P. Small, Wankei Wan, “Statistical Optimization of Culture Conditions for Bacterial Cellulose Production by Acetobacter xylinum BPR 2001 from Maple Syrup” Carbohydrate Polymers 85: 506 – 513 (2011) Karen L. Kennedy, Alexandra R. Lucas, Wankei Wan, “Local Delivery of Therapeutics for Percutaneous Interventions” Current Drug Delivery 8(5): 534 – 556 (2011) Mina Mekhail, Kenneth Wong, Yan Wu, David B. O'Gorman, Wankei Wan, “Genipin-Crosslinked Electrospun Collagen Fibers” Journal of Biomaterials Science: Polymer Edition 22: 2241 – 2259 (2011) Donna Padavan, Amanda Hamilton, Derek Boughner and Wankei Wan, “Synthesis and In Vitro Biocompatibility Assessment of a Poly(amic Acid) Derived from Ethylenediaminetetraacetic dianhydride” Journal of Biomaterials Science: Polymer Edition 22: 683 – 700 (2011) Donna T. Padavan, Amanda M. Hamilton, Leonardo E. Millon, Derek D. Boughnera, and Wankei Wan, “Synthesis, Characterization and in Vitro Cell Compatibility Study of a Poly(amic Acid) Graft Poly(vinyl Alcohol) Hydrogel” Acta Biomaterialia 7: 258 – 267 (2011) Donna Padavan and Wankei Wan, “Synthesis and Characterization of a Novel Versatile Poly(amic Acid) Derived from Ethylenediaminetetraacetic Dianhydride” Materials Chemistry and Physics 124: 427 – 433 (2010) Nermen Maximous, George Nakhla, Wankei Wan, Kenneth Wong, “Effect of the Metal Oxide Particle Distributions on Modified PES Membranes Characteristics and Performance” Journal of Membrane Science 361: 213–222 (2010) Suanne Mahabir, Wankei Wan, John Katsaras and Mu-Ping Nieh, “The Effects of Charge Density and Thermal History on the Morphologies of Spontaneously Formed Unilamellar Vesicles” Journal of Physical Chemistry B. 114: 5729-5735 (2010). Nermen Maximous, George Nakhla, Kenneth Wong and Wankei Wan, “Optimization of Al2O3/PES Membranes for Wastewater Filtration” Separation and Purification Technology 73(2): 294-301(2010) Nermen Maximous, George Nakhla, Wankei Wan and Kenneth Wong, “Performance of a Novel ZrO2 /PES Membrane for Wastewater Filtration” Journal of Membrane Science 352: 222–230 (2010) Anne Hsieh, Tasneem Zahir, Yakov Lapitsky, Brian Amsden, Wankei Wan, Molly S. Shoichet, “Hydrogel/Electrospun Fiber Composites Influence Neural Stem/Progenitor Cell Fate” Soft Matters 6: 2227–2237 (2010) Kenneth Wong, Martin Zinke-Allmang, Wankei Wan, “Effect of Annealing on Aqueous Stability and Elastic Modulus of Electrospun Poly(vinyl Alcohol) Fibers” Journal of Materials Science 45:2456–2465 (2010) Kenneth Wong, Martin Zinke-Allmang, Jeffrey L. Hutter, Sabahudin Hrapovic, John H.T. Luong, Wankei Wan, “The Effect of Carbon Nanotube Aspect Ratio and Loading on the Elastic Modulus of Electrospun Poly(vinyl Alcohol)-Carbon Nanotube Hybrid Fibers” Carbon 47(11): 2571–2578 (2009) Nermen Maximous, George Nakhla, Wankei Wan, Kenneth Wong, “Preparation, Characterization and Performance of Al2O3/PES Membrane for Wastewater Filtration” Journal of Membrane Science 341(1–2): 67–75 (2009) Kenneth Wong, Jeffrey L. Hutter, Martin Zinke-Allmang, Wankei Wan, “Physical Properties of Ion Beam Treated Electrospun Poly(vinyl Alcohol) Nanofibers”. European Polymer Journal 45(5): 1349–1358 (2009) Stephen D. Hudson, Jeffrey L. Hutter, Mu-Ping Nieh, Jeremy Pencer, Leonardo E. Millon and Wankei Wan, “Characterization of Anisotropic Poly(Vinyl Alcohol) Hydrogel by Small and Ultra Small-Angle Neutron Scattering” Journal of Chemical Physics 130: 034903 (2009) Leonardo E. Millon, Christine J. Oates, Wankei Wan, “Compression Properties of Polyvinyl Alcohol – Bacterial Cellulose Nanocomposite” Journal of Biomedical Materials Research 90B: 922–929 (2009) Hadi Mohammadi, Fereshteh Bahramian, Wankei Wan, “Advanced Modeling Strategy for the Analysis of Heart Valve Leaflet Tissue Mechanics using High-Order Finite Element Method” Medical Engineering and Physics 31: 1110-1117 (2009) Hadi Mohammadi, Derek Boughner, Leonardo E. Millon, Wankei Wan, “Design and Simulation of a Poly(vinyl Alcohol)-Bacterial Cellulose Nanocomposite Mechanical Aortic Heart Valve Prosthesis” Journal of Engineering in Medicine 223 (H6): 697-712 (2009) Hadi Mohammadi, Wankei Wan, “A Novel Numerical Corrective Technique to Mass Spring Systems” International Journal for Computational Vision and Biomechanics 2, 81-85 (2009)