Koh, Ming Joo - National University of Singapore - Department of Chemistry, Faculty of Science

个人简介

Ph.D. & Post-Doc in Organic Chemistry (2012–2018), Boston College, MA, USA Advisor: Prof. Amir H. Hoveyda B.Sc. in Chemistry & Biological Chemistry, First Class Honors (2008–2012), Nanyang Technological University, Singapore Advisor: Prof. Philip Wai Hong Chan Dr. Ming Joo (MJ) Koh Ming Joo (MJ) Koh was born and raised on the sunny island of Singapore. As a research assistant in Professor Philip Chan's group during his undergraduate years at Nanyang Technological University (NTU), MJ worked on a number of projects that employed gold-catalyzed alkene and alkyne cycloisomerization transformations to furnish architecturally distinct heterocyclic compounds. Upon graduating from NTU with a Bachelor of Science (First Class Honours) degree, MJ pursued his Ph.D. and post-doctoral studies under the tutelage of Professor Amir H. Hoveyda at Boston College, USA. In collaboration with Professor Richard R. Schrock's group at Massachusetts Institute of Technology, MJ's doctoral research mainly focused on developing catalytic stereoselective olefin metathesis protocols to access stereoisomerically pure alkenes for applications in natural product and pharmaceutical synthesis. As a post-doctoral fellow, MJ shifted his focus to developing catalytic stereoselective transformations involving organofluorine compounds. In June 2018, MJ was awarded the President's Assistant Professorship to commence his independent studies at the Chemistry Department of the National University of Singapore. AWARDS & HONORS LaMattina Family Graduate Fellowship in Chemical Synthesis: 2016 BMS Graduate Fellowship in Synthetic Organic Chemistry: 2016-2017 NUS Inauguration Grant: 2019 Asian Core Program Lectureship Award (China, Thailand): 2019 Excellent Young Teacher Award: 2019-2020 Innovators Under 35 (TR35) Asia Pacific Award: 2021 TCI-SNIC Industry Award in Synthetic Chemistry: 2021 Thieme Chemistry Journals Award: 2022 C&EN's Talented 12: 2022 Asian Core Program Lectureship Award (Japan, Korea): 2022 Young Scientist Award, SNAS: 2022 Faculty Young Scientist Award, Faculty of Science, NUS: 2022 Asian Scientist 100: 2023 Young Researcher Award, NUS: 2023

研究领域

(a) Development of catalytic regio- and stereoselective alkene functionalization reactions. (b) Discovery of new catalytic manifolds that engage radicals in cross-coupling transformations. (c) Development of catalytic protocols for the stereoselective synthesis of carbohydrates. (d) Design of new heterogeneous single-atom catalysts for liquid-phase organic synthesis (collaboration with materials chemists). (e) Elucidation of catalytic mechanisms through mechanistic and computational studies (collaboration with computational chemists). (f) Plastic waste upcycling using base metal catalysis (collaboration with materials chemists).

近期论文

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Wang, Z.-C.; Luo, X.; Zhang, J.-W.; Liu, C.-F.; Koh, M. J.*; Shi, S.-L.* Nat. Catal. 2023. Hai, X.; Zheng, Y.; Yu, Q.; Guo, N.; Xi, S.*; Zhao, X.; Mitchell, S.; Luo, X.; Tulus, V.; Wang, M.; Sheng, X.; Ren, L.; Long, X.; Li, J.; He, P.; Lin, H.; Cui, Y.; Peng, X.; Shi, J.; Wu, J.; Zhang, C.; Zou, R.; Guillén-Gosálbez, G.; Pérez-Ramírez, J.*; Koh, M. J.*; Zhu, Y.*; Li, J.*; Lu, J.* Nature 2023, Zhang, W.; Liu, T.; Ang, H T.; Luo, P.; Lei, Z.; Luo, X.; Koh, M. J.*; Jie, W.* "Modular and Practical 1,2-Aryl(alkenyl) Heteroatom Functionalization of Alkenes through Iron/Photoredox Dual Catalysis" Angew. Chem. Int. Ed. 2023, DOI: 10.1002/anie.202310978. Jiang, Y.; Zhang, Y.; Lee, B. C.; Koh, M. J.* "Diversification of Glycosyl Compounds via Glycosyl Radicals" Angew. Chem. Int. Ed. 2023, 62, e202305138. Lee, B. C.; Liu, C.-F.; Lin, L. Q. H.; Yap, K. Z.; Song, N.; Ko, C. H. M.; Chan, P. H.; Koh, M. J.* "N-Heterocyclic Carbenes as Privileged Ligands for Nickel-Catalysed Alkene Functionalisation" Chem. Soc. Rev. 2023, 52, 2946. Wang, Q.; Lee, B. C.; Song, N.; Koh, M. J.* "Stereoselective C-Aryl Glycosylation by Catalytic Cross-Coupling of Heteroaryl Glycosyl Sulfones" Angew. Chem. Int. Ed. 2023, 62, e202301081. Wei, Y.; Wang, Q.*; Koh, M. J.* "A Photoinduced, Nickel-Catalyzed Reaction for the Stereoselective Assembly of C-Linked Glycosides and Glycopeptides" Angew. Chem. Int. Ed. 2023, 62, e202214247. Yang, H.; Xi, S.; Guo, N.; Wang, M.; Liu, L.; Lyu, P.; Yu, X.; Li, J.; Xu, H.; Hai, X.; Li, Z.; Li, X.; Sun, T.; Zhao, X.; Han, Y.; Yu, W.; Wu, J.; Zhang, C.*; Fei, H.*; Koh, M. J.*; Lu, J.* "Catalytically Active Atomically Thin Cuprate with Periodic Cu Single Sites" Natl. Sci. Rev. 2023, 10, nwac100. Liu, C-.F.; Wang, Z.-C.; Luo, X.; Lu, J.; Ko, C. H. M.; Shi, S.-L.*; Koh, M. J.* "Synthesis of Tri- and Tetrasubstituted Stereocentres by Nickel-Catalysed Enantioselective Olefin Cross-Couplings" Nat. Catal. 2022, DOI: 10.1038/s41929-022-00854-8. (highlighted by X-mol). Jiang, Y.; Yang, K.; Wei, Y.; Wang, Q.*; Li, S.-J.*; Lan, Y.*; Koh, M. J.* "Catalytic Multicomponent Synthesis of C-Acyl Glycosides by Consecutive Cross-Electrophile Couplings" Angew. Chem. Int. Ed. 2022, DOI: 10.1002/anie.202211043. Wang, Q.; Lee, B. C.; Tan, T. J.; Jiang, Y.; Ser, W. H.; Koh, M. J.* "Visible Light Activation Enables Desulfonylative Cross-Coupling of Glycosyl Sulfones" Nat. Synth. 2022, DOI: 10.1038/s44160-022-00162-w. (highlighted by NUS Science, Phys.org, C&EN, X-mol). Yang, H.; Xi, S.; Guo, N.; Wang, M.; Liu, L.; Lyu, P.; Yu, X.; Li, J.; Xu, H.; Hai, X.; Li, Z.; Li, X.; Sun, T.; Zhao, X.; Han, Y.; Yu, W.; Wu, J.; Zhang, C.*; Fei, H.*; Koh, M. J.*; Lu, J.* "Catalytically Active Atomically Thin Cuprate with Periodic Cu Single Sites" Natl. Sci. Rev. 2022, nwac100. (highlighted by Phys.org, EurekAlert!) Chen, Z.; Song, J.; Zhang, R.; Li, R.; Hu, Q.; Wei, P.; Xi, S.; Zhou, X.; Phuc, N. T. T.; Minh, D. H.; Lee, P. S.; Zhao, X.; Koh, M. J.; Yan, N.; Loh, K. P. "Addressing the Quantitative Conversion Bottleneck in Single-Atom Catalysis" Nat. Commun. 2022, 13, 2807. Wang, H.; Koh, M. J.* "Directing Group-Free Approaches for Three-Component Catalytic Dicarbofunctionalization of Unactivated Alkenes" Cell Rep. Phys. Sci. 2022, 3, 100901. (invited perspective). Zhao, Y.; Liu, C.-F.; Lin, L. Q. H.; Chan, A. S. C.*; Koh, M. J.* "Stereoselective Synthesis of Trisubstituted Alkenes by Nickel-Catalyzed Benzylation and Alkene Isomerization" Angew. Chem. Int. Ed. 2022, 61, e202202674. Wang, Q.; Sun, Q.; Jiang, Y.; Zhang, H.; Yu, L.; Tian, C.; Chen, G.*; Koh, M. J.* "Iron-Catalysed Reductive Cross-Coupling of Glycosyl Radicals for the Stereoselective Synthesis of C-Glycosides" Nat. Synth. 2022, 1, 235. Huang, L.; Lim, E. Q.; Koh, M. J.* "Secondary Phosphine Oxide-Activated Nickel Catalysts for Site-Selective Alkene Isomerization and Remote Hydrophosphination" Chem Catal. 2022, 2, 508. (Pre-print uploaded on ChemRxiv 2021, DOI: 10.33774/chemrxiv-2021-cld3z.) Wang, H.; Liu, C.-F.; Tan, T.-D.; Khoo, K. R. B.; Koh, M. J.* "N-Heterocyclic Carbene–Nickel-Catalyzed Regioselective Diarylation of Aliphatic-1,3-Dienes" ACS Catal. 2022, 12, 724. Wang, H.; Liu, C.-F.; Martin, R. T.; Gutierrez, O.*; Koh, M. J.* "Directing Group-Free Catalytic Dicarbofunctionalization of Unactivated Alkenes" Nat. Chem. 2022, 14, 188. (highlighted by SYNFACTS, Synfacts 2022, 18, 323, NUS Science, Phys.org, C&EN, X-mol) Li, P.; Lee, B. C.; Zhang, X.; Koh, M. J.* "Base-Mediated Site-Selective Hydroamination of Alkenes" Synthesis 2022, 54, 1566. (invited feature article). Chen, Z.; Liu, J.; Koh, M. J.; Loh, K. P. "Single-Atom Catalysis: From Simple Reactions to the Synthesis of Complex Molecules" Adv. Mater. 2022, 34, 2103882. Liu, J.; Chen, Z.; Koh, M. J.; Loh, K. P. "Deuterium labelling by electrochemical splitting of heavy water" Energy Mater. 2021, 1, 100016. Jiang, Y.; Wang, Q.*; Zhang, X.*; Koh, M. J.* "Synthesis of C-Glycosides by Ti-Catalyzed Stereoselective Glycosyl Radical Functionalization" Chem 2021, 7, 3377. (highlighted by NUS Science, Phys.org). Yoon, J.; Grinchuk, O. V.; Kannan, S.; Ang, M. J. Y.; Li, Z.; Tay, E. X. Y.; Lok, K. Z.; Lee, B. W. L; Chuah, Y. H.; Chia, K.; Magallanes, R. T.; Liu, C.-F.; Zhao, H.; Hor, J. H.; Lim, J. J.; Benoukraf, T.; Toh, T. B.; Chow, E. K.-H.; Kovalik, J.-P.; Ching, J.; Ng, S.-Y.; Koh, M. J.; Liu, X.; Verma, C. S.; Ong, D. S. T. "A Chemical Biology Approach Reveals a Dependency of Glioblastoma on Biotin Distribution" Sci. Adv. 2021, 7, eabf6033. Liu, C.-F.; Wang, H.; Martin, R. T.; Zhao, H.; Gutierrez, O.*; Koh, M. J.* "Olefin Functionalization/Isomerization Enables Stereoselective Alkene Synthesis" Nat. Catal. 2021, 4, 674. (highlighted by NUS Science, Phys.org, X-mol). Chen, C.; Ou, W.; Yam, K.-M. Xi, S.; Zhao, X.; Chen, S.; Li, J.; Lyu, P.; Ma, L.; Du, Y.; Yu, W.; Fang, H.; Yao, C.; Hai, X.; Xu, H.; Koh, M. J.; Pennycook, S. J.; Lu, J.; Lin, M.; Su, C.; Zhang, C.; Lu, J. "Zero-Valent Palladium Single-Atoms Catalysts Confined in Black Phosphorus for Efficient Semi-Hydrogenation" Adv. Mater. 2021, 33, 2008471. Chen, Z.; Song, J.; Peng, X.; Xi, S.; Liu, J.; Zhou, W.; Li, R.; Ge, R.; Liu, C.; Xu, H.; Zhao, X.; Li, H.; Zhou, X.; Wang, W.; Li, X.; Zhong, L.; Rykov, A. I.; Wang, J.; Koh, M. J.; Loh, K. P. "Iron Single Atom Catalyzed Quinoline Synthesis" Adv. Mater. 2021, 33, 2101382. Liu, C.-F.; Luo, X.; Wang, H.*; Koh, M. J.* "Catalytic Regioselective Olefin Hydroarylation(alkenylation) by Sequential Carbonickelation-Hydride Transfer" J. Am. Chem. Soc. 2021, 143, 9498. (highlighted by Organic Chemistry Portal).