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个人简介

Education B.S., Nanjing University, 1993-1997 Advisor: Yun Lu M.S., Nanjing University, 1997-2000 Advisor: Yun Lu Ph.D., Washington University in St. Louis, 2002-2006 Advisor: John-Stephen A. Taylor Postdoctoral Associate, Yale University, 2007-2009 Advisor: Andrew D. Hamilton Affiliations and Positions USF Preeminent Professor, Department of Chemsitry, USF, 2020- Director, Center for Molecular Diversity in Drug Design, Discovery and Development (CMD5), USF, 2019- Professor, Department of Chemsitry, USF, 2018- Associate professor, Department of Chemsitry, USF, 2015-2018 Assistant professor, Department of Chemsitry, USF, 2009-2015 Member, American Peptide Society, 2014- Member, Moffitt Cancer Center & Research Institute, 2009- Member, American Chemical Society, 2005-

研究领域

AApeptide Folding Structure-Based Design Combinatorial Screening Supramolecular Chemistry

近期论文

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Xing Zhang,+ Minghui Wang,+ Xiaodi Zhu, Yan Peng, Tiwei Fu, Chang-Hua Hu, Jianfeng Cai,* Guojian Liao.* Development of lipo-γ-AA peptides as potent antifungal agents.J. Med. Chem. 2022, ASAP. Feng Li,+ Liming Lin,+ Jiaying Chi, Hui Wang, Minqun Du, Disang Feng, Liqing Wang, Rui Luo, Hangping Chen, Guilan Quan, Jianfeng Cai, Xin Pan, Chuanbin Wu, Chao Lu.* Guanidinium-Rich Lipopeptide Functionalized Bacteria-Absorbing Sponge as an Effective Trap-and-Kill System for the Elimination of Focal Bacterial Infection.Acta Biomaterialia 2022, ASAP. Peng Sang, Yan Shi, Lulu Wei, and Jianfeng Cai.* Helical Sulfono-γ-AApeptides with Predictable Functions in Protein Recognition. RSC Chem. Biol. 2022, ASAP. Yanhong Wang, Yuzhu Hong, Jiyu Yan, Breanna Brown, Xiaoyang Lin, Xiaolin Zhang, Ning Shen, Minghua Li, Jianfeng Cai, Marcia Gordon, David Morgan, Qingyu Zhou,* and Chuanhai Cao.* Low-Dose Delta-9-Tetrahydrocannabinol as Beneficial Treatment for Aged APP/PS1 Mice. Int. J. Mol. Sci. 2022. 23, 5, 2757. Wei Jiang,+ Lulu Wei,+ Bing Chen, Xingyu Luo, Peipei Xu, Jianfeng Cai, and Yong Hu.* Platinum Prodrug Nanoparticles Inhibiting Tumor Recurrence and Metastasis by Concurrent Chemoradiotherapy. J. Nano. Biotechnol. 2022. 20:129. Jintao Fu,Ting Liu, Xiaoqian Feng, Yixian Zhou, Minglong Chen, Wenhao Wang, Yiting Zhao, Chao Lu, Guilan Quan, Jianfeng Cai, Xin Pan*, Chuanbin Wu. Perfect Pair: Stabilized Black Phosphorous Nanosheets Engineering with Antimicrobial Peptides for Robust Multi-Drug Resistant Bacteria Eradication. Adv Healthc Mater. 2022. e2101846. Peng Teng* and Jianfeng Cai.* Using Proteomimetics to Switch Angiogenic Signaling. Acta Pharmaceutica Sinica B 2022. 1534-1535. Bo Huang,+ Li Zhou,+ Ruochuan Liu,+ Lei Wang, Songyi Xue, Yan Shi, Geon Ho Jeong, In Ho Jeong, Sihao Li, Jun Yin,* Jianfeng Cai.* Activation of E6AP/UBE3A-Mediated Protein Ubiquitination and Degradation Pathways by a Cyclic Gamma-AApeptide. J. Med. Chem. 2022. ASAP. Sami Abdulkadir,+ Chunpu Li,+ Wei Jiang,+ Xue Zhao, Peng Sang, Lulu Wei, Yong Hu,* Qi Li,* and Jianfeng Cai.* Modulating Angiogenesis by Proteomimetics of Vascular Endothelial Growth Factor. J. Am. Chem. Soc., 2022, ASAP. Lulu Wei and Jianfeng Cai.* Novel Peptides and Peptidomimetics in Drug Discovery. Acta Pharmaceutica Sinica B, 2021, 2606-2608. Maochao Zheng, Huanchang Lina, Wancong Zhang, Shijie Tang,* Daojun Liu,* and Jianfeng Cai.* Poly(L-ornithine)-grafted zinc phthalocyanines as dual-functional antimicrobial agents with intrinsic membrane damage and photothermal ablation capacity. ACS Infect. Dis. 2021, 7, 10, 2917–2929. Peng Sang,+ Hongxiang Zeng,+ Candy Lee,+ Yan Shi, Minghui Wang, Cong Pan, Lulu Wei, Chenglong Huang, Mingjun Wu, Weijun Shen,* Xi Li,* and Jianfeng Cai.* α/sulfono-γ-AApeptide Hybrid Analogues of Glucagon with Enhanced Stability and Prolonged in vivo Activity. J. Med. Chem. 2021, 64, 18, 13893–13901. Mengmeng Zheng,+ Chunpu Li,+ Mi Zhou,+ Ru Jia, Gang Cai, Fengyu She, Lulu Wei, Shaohui Wang, Jie Yu, Dingyan Wang, Laurent Calcul, Xingmin Sun, Xiaomin Luo, Feng Cheng, Qi Li,* Yan Wang,* and Jianfeng Cai.* Discovery of Cyclic Peptidomimetic Ligands Targeting the Extracellular Domain of EGFR. J. Med. Chem. 2021, 64, 15, 11219-11228. Wei Jiang, Xingyu Luo, Lulu Wei, Shanmei Yuan, Jianfeng Cai,* Xiqun Jiang,* and Yong Hu.* The Sustainability of Energy Conversion Inhibition for Tumor Ferroptosis Therapy and Chemotherapy. Small, 2021, 17, 38, 2102695. Mengmeng Zheng,+ Chunpu Li,+ Mi Zhou,+ Ru Jia, Fengyu She, Lulu Wei, Feng Cheng, Qi Li, * Jianfeng Cai* and Yan Wang.* Peptidomimetic-based antibody surrogate for HER2. Acta Pharmaceutica Sinica B, 2021, 2645-2654. Yingru Zhang,+ Chunpu Li,+ Ru Jia,+ Ruixuan Gao, Yiyang Zhao, Qing Ji, Jianfeng Cai,* Qi Li,* and Yan Wang.* PEG-poly(amino acid)s/EpCAM aptamer multifunctional nanoparticles arrest the growth and metastasis of colorectal cancer. Biomater. Sci. 2021, 9, 3705-3717.Link Song Qing, Han Zhifen, Xinnan Wu, Yan Wang, Lihong Zhou, Liu Yang, Ningning Liu, Hua Sui, Jianfeng Cai, Qing Ji,* Li Qi.* β-arrestin1 promotes colorectal cancer metastasis through GSK-3β/β-catenin signaling-mediated epithelial-to-mesenchymal transition. Frontiers Cell Develop. Biol. 2021, 9, 650067. Yan Shi, Peng Sang and Jianfeng Cai.*. Discovery of α‑Helix-Mimicking Sulfono-γ-AApeptides as p53−MDM2 inhibitors. Future. Med. Chem. 2021, 12, 1021-1023. Minghui Wang,+ Xiaoqian Feng,+ Ruixuan Gao, Peng Sang, Xin Pan, Lulu Wei, Chao Lu,* Chuanbin Wu,* Jianfeng Cai.* Modular Design of Membrane Active Antibiotics: From Macromolecular Antimicrobials to Small Scorpion-like Peptidomimetics. J. Med. Chem. 2021, 64, 14, 9894-9905. Peng Teng,*,+ Mengmeng Zheng,+ Darrell Cole Cerrato, Yan Shi, Mi Zhou, Songyi Xue, Wei Jiang, Lukasz Wojtas, Li-June Ming, Yong Hu,* Jianfeng Cai.* The Folding Propensity of α/Sulfono-γ-AA Peptidic Foldamers with Both Left- and Right-Handedness. Commun. Chem. 2021, 58, 4.

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