个人简介

B.A., B.S., Indiana University of Pennsylvania, 1993; M.A., Yale University, 1996; Ph.D., 1997. Assistant Professor, Caltech, 2000-06; Associate Professor, 2006-07; Professor, 2007-; Bowles Professor, 2007-12. Executive Officer, 2010-12.

研究领域

Research in the Stoltz group has been initiated in the general area of chemical synthesis with a focus on the development of new strategies for the preparation of complex molecules possessing interesting structural, biological, and physical properties. In concert with the design and development of unique and efficient synthetic strategies, we will develop new techniques and methods which will be useful in far reaching and unanticipated applications, as well as for the synthesis of the initial inspirational target. Thus, the general research paradigm within the Stoltz laboratory will be to utilize architecturally complex target molecules as the driving force behind the development of new reactions, which extend the limits of the science. Ultimately, we will have access to important biologically active compounds prepared through novel and efficient routes, as well as new techniques for the preparation of other structurally unique targets.

Chemistry

近期论文

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"Concise total syntheses of (–)-jorunnamycin A and (–)-jorumycin enabled by asymmetric catalysis" Eric R. Welin, Aurapat Ngamnithiporn, Max Klatte, Guillaume Lapointe, Gerit M. Pototschnig, Martina S. J. McDermott, Dylan Conklin, Christopher D. Gilmore, Pamela M. Tadross, Christopher K. Haley, Kenji Negoro, Emil Glibstrup, Christian U. Grünanger, Kevin M. Allan, Scott C. Virgil, Dennis J. Slamon, and Brian M. Stoltz. Science 2018, First Release. [Supporting Information]. "Concise Syntheses of Δ12-Prostaglandin J Natural Products via Stereoretentive Metathesis" Jiaming Li, Tonia S. Ahmed, Chen Xu, Brian M. Stoltz, and Robert H. Grubbs. J. Am. Chem. Soc. 2018, ASAP [Supporting Information]. "Discussion Addendum for: Preparation of (S)-tert-ButylPHOX and (S)-2-Allyl-2-Methylcyclohexanone" Alexander W. Sun and Brian M. Stoltz. Org. Synth. 2018, 95, 439–454. "The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination" Christopher G. Jones†, Michael W. Martynowycz†, Johan Hattne, Tyler J. Fulton, Brian M. Stoltz, Jose A. Rodriguez, Hosea M. Nelson, and Tamir Gonen. ACS Cent. Sci. 2018, 4, 1587–1592. †Equal Contribution. [Supporting Information]. ChemRXiv Preprint. Caltech Feature Story "Enantioselective Synthesis of gem-Disubstituted N-Boc Diazaheterocycles via Decarboxylative Asymmetric Allylic Alkylation" Alexander W. Sun†, Stephan N. Hess† and Brian M. Stoltz. Chem. Sci. 2018, Accepted. †Equal Contribution. [Supporting Information]. "Catalyst-Controlled Selective Functionalization of Unactivated C–H Bonds in the Presence of Electronically Activated C–H Bonds" Wenbin Liu, Zhi Ren, Aaron T. Bosse, Kuangbiao Liao, Elizabeth L. Goldstein, John Bacsa, Djamaladdin G. Musaev, Brian M. Stoltz, and Huw M. L. Davies. J. Am. Chem. Soc. 2018, 140, 12247–12255. [Supporting Information]. "Palladium-Catalyzed Enantioselective Csp3–Csp3 Cross-Coupling for the Synthesis of (Poly)fluorinated Chiral Building Blocks" Yanhui Lu, Elizabeth L. Goldstein, and Brian M. Stoltz. Org. Lett. 2018, 20, 5657–5660. [Supporting Information]. "Synergistic O3 + OH oxidation pathway to extremely low-volatility dimers revealed in β-pinene secondary organic aerosol" Christopher M. Kenseth, Yuanlong Huang, Ran Zhao, Nathan F. Dalleska, J. Caleb Hethcox, Brian M. Stoltz, and John H. Seinfeld. Proc. Natl. Acad. Sci. U S A 2018, 115, 8301–8306. [Supporting Information]. "Intermolecular Stereoselective Iridium-Catalyzed Allylic Alkylation: An Evolutionary Account" Samantha E. Shockley, J. Caleb Hethcox, and Brian M. Stoltz. Synlett 2018, 29, A–L. "General and Practical KOMe/Disilane-Mediated Dehalogenative Deuteration of (Hetero)Arylhalides" Xin Wang, Ming-Hui Zhu, David P Schuman, Dayou Zhong, Wen-Yan Wang, Lin-Yang Wu, Wei Liu, Brian M. Stoltz, and Wen-Bo Liu. J. Am. Chem. Soc. 2018, 140,10970–10974 [Supporting Information]. "Catalytic Enantioselective Synthesis of Acyclic Quaternary Centers: Palladium-Catalyzed Decarboxylative Allylic Alkylation of Fully Substituted Acyclic Enol Carbonates" Eric J. Alexy, Haiming Zhang, and Brian M. Stoltz. J. Am. Chem. Soc. 2018, 140, 10109–10112. [Supporting Information]. This article was featured in Synfacts! "Short Enantioselective Formal Synthesis of (–)-Platencin" Christian Defieber, Justin T. Mohr , Gennadii A. Grabovyi, Brian M. Stoltz. Synthesis 2018, 50, A–J [Supporting Information]. "Total Synthesis of the Norhasubanan Alkaloid Stephadiamine" Nina Hartrampf, Nils Winter, Gabriele Pupo, Brian M. Stoltz, and Dirk Trauner. J. Am. Chem. Soc. 2018, 140, 8675–8680. [Supporting Information]. This article was featured in Synfacts! "Enantioselective Synthesis of Vicinal All‐Carbon Quaternary Centers via Iridium‐Catalyzed Allylic Alkylation" J. Caleb Hethcox, Samantha E. Shockley, and Brian M. Stoltz. Angew. Chem. Int. Ed. 2018, 57, 1–5. [Supporting Information]. This article was featured in Synfacts! "Enantioselective palladium-catalyzed allylic alkylation reactions in the synthesis of Aspidosperma and structurally related monoterpene indole alkaloids" Beau P. Pritchett and Brian M. Stoltz. Nat. Prod. Rep. 2018, 35, 559-574. "Development of a Unified Enantioselective, Convergent Synthetic Approach Toward the Furanobutenolide-Derived Polycyclic Norcembranoid Diterpenes: Asymmetric Formation of the Polycyclic Norditerpenoid Carbocyclic Core by Tandem Annulation Cascade" Robert A. Craig, II, Russell C. Smith, Jennifer L. Roizen, Amanda C. Jones, Scott C. Virgil, and Brian M. Stoltz. J. Org. Chem. 2018, 83, 3467–3485. [Supporting Information]. "Nickel-Catalyzed Enantioselective Allylic Alkylation of Lactones and Lactams with Unactivated Allylic Alcohols" Fa Ngamnithiporn, Carina Jette, Shoshana Bachman, Scott Virgil, and Brian M. Stoltz. Chemical Science 2018, 9, 2547-2551. [Supporting Information]. "The Cyanthiwigin Natural Product Core as a Complex Molecular Scaffold for Comparative Late-Stage C–H Functionalization Studies" Kelly E. Kim, Ashley M. Adams, Nicholas D. Chiappini, J. Du Bois, and Brian M. Stoltz J. Org. Chem. 2018, 83, 3023–3033. [Supporting Information]. This article was featured on the March 16, 2018 cover of JOC! It was also an Editor's Choice article! "Wolff/Cope Approach to the AB Ring of the Sesterterpenoid Variecolin" Michael R Krout, Christopher Edwin Henry, Thomas Jensen, Kun-Liang (Phil) Wu, Scott C Virgil, and Brian M. Stoltz J. Org. Chem. 2018, 83, 6995–7009. [Supporting Information]. "Atmospheric autoxidation is increasingly important in urban and suburban North America" Eric Praske, Rasmus V. Otkjær, John D. Crounse, J. Caleb Hethcox, Brian M. Stoltz, Henrik G. Kjaergaard, and Paul O. Wennberg. PNAS 2017, 115, 64-69. [Supporting Information]. "Isocanthine Synthesis via Rh(III)-Catalyzed Intramolecular C–H Functionalization" Anthony Y. Chen, Qianqian Lu, Yao Fu, Richmond Sarpong, Brian M. Stoltz, and Haiming Zhang. JOC 2017, 83, 330–337. [Supporting Information]. "Model Studies To Access the [6,7,5,5]-Core of Ineleganolide Using Tandem Trans lactonization Cope or Cyclopropanation Cope Rearrangements as Key Steps" Jennifer L. Roizen, Amanda C. Jones, Russell C. Smith, Scott C. Virgil, and Brian M. Stoltz. JOC 2017, 82, 13051–13067. [Supporting Information]. "Catalytic Reduction of Alkyl and Aryl Bromides using Isopropanol" Michael C. Haibach, Brian M. Stoltz, and Robert H. Grubbs. ACIE 2017, 56, 15123–15126 . [Supporting Information]. "Sequential Ruthenium Catalysis for Olefin Isomerization and Oxidation: Application to the Synthesis of Unusual Amino Acids" Marc Liniger, Yiyang Liu, and Brian M. Stoltz. JACS 2017, 139, 13944–13949. [Supporting Information]. "Enantioselective Pd-Catalyzed Decarboxylative Allylic Alkylation of Thiopyranones. Access to Acyclic, Stereogenic α-Quaternary Ketones" Eric J. Alexy, Scott C. Virgil, Michael D. Bartberger, and Brian M. Stoltz. Org. Lett. 2017, 19, 5007–5009. [Supporting Information]. This article was featured in Synfacts! "Progress towards the total synthesis of hamigerans C and D: a direct approach to an elaborated 6-7-5 carbocyclic core" Doug C. Duquette, Thomas Jensen, and Brian M. Stoltz. J. Antibiot. 2017, 71, 263–267. [Supporting Information]. "Enantioselective Catalysis Coupled with Stereodivergent Cyclization Strategies Enables Rapid Syntheses of (+)-Limaspermidine and (+)-Kopsihainanine A" Beau P. Pritchett,† Etienne J. Donckele,† Brian M. Stoltz ACIE 2017, 56, 12624 –12627. [Supporting Information]. †Equal Contribution.