个人简介

B.A., Boston University (1994) Ph.D., Indiana University (1999) NIH Postdoctoral Fellow, Memorial Sloan-Kettering Cancer Center, NY, NY (1999-2002) Awards and Honors and Professional Service: ACS Administered PRFG (2004-2006) Thieme Journal Prize (2008) Chair-elect, Chair, Western New York ACS (2007-2009) Organic Letters Advisory Board (2011-2016) NIH SBCA Study Section Member (2013-2017)

研究领域

Medicinal Chemistry and Chemical Biology/Organic Chemistry

Research in the Chemler group involves the development and study of new organic and organometallic reactions and the application of these reactions to the synthesis of valuable natural products and designed molecules with interesting molecular architecture and potent biological activity. The Chemler group has recently discovered novel oxidative cyclization chemistry enabled by relatively inexpensive and non-toxic copper salts. In this context, the generality, mechanism and application of the copper promoted/catalyzed intramolecular carboamination, diamination and aminooxygenation of unactivated olefins are being explored. The efficiency of these methods in the synthesis of medicinally relevant nitrogen heterocycles is underway.

近期论文

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"T. W. Liwosz, S. R. Chemler (2014), ""Copper-Catalyzed Synthesis of N-Aryl and N-Sulfonyl Indoles from 2-Vinylanilines with O2 as Terminal Oxidant and TEMPO as Co-Catalyst,"" Synlett, in press. B. J. Casavant, A. S. Hosseini, S. R. Chemler (2014), ""6-Azabicyclo[3.2.1]octanes Via Copper-Catalyzed Enantioselective Alkene Carboamination,"" Adv. Syn. Cat. 356, 2697. M. T. Bovino, T. W. Liwosz, N. E. Kendel, Y. Miller, N. Tyminska, E. Zurek, S. R. Chemler (2014), ""Enantioselective Copper-Catalyzed Carboetherification of Unactivated Alkenes,"" Angew. Chem. Int. Ed. 53, 6383. B. W. Turnpenny, S. R. Chemler (2014), ""Copper-Catalyzed Alkene Diamination: Synthesis of Chiral 2-Aminomethylindolines and Pyrrolidines,"" Chem. Sci. 5, 1786. L. Belding, S. R. Chemler, T. Dudding (2013), ""A Computational Study of the Copper(II)-Catalyzed Enantioselective Intramolecular Aminooxygenation of Alkenes,"" J. Org. Chem. 78, 10288. S. R. Chemler (2013), ""Copper's Contribution to Amination Catalysis,"" Science, 341, 624-626. T. W. Liwosz, S. R. Chemler (2013), ""Copper-Catalyzed Oxidative Amination and Allylic Amination of Alkenes,"" Chem.--Eur. J. 19. 12771. T. W. Liwosz, S. R. Chemler (2013), ""Copper-Catalyzed Oxidative Heck Reactions between Alkyltrifluoroborates and Vinyl Arenes,"" Org. Lett. 15, 3034-3037. S. R. Chemler, M. T. Bovino (2013), ""Catalytic Aminohalogenation of Alkenes and Alkynes,"" ACS Catalysis, 3, 1076-1091. M. C. Paderes, J. B. Keister, S. R. Chemler (2013), ""Mechanistic Analysis and Optimization of the Copper-Catalyzed Enantioselective Intramolecular Alkene Aminooxygenation,"" J. Org. Chem., 78, 506-515. S. R. Chemler, B. J. Casavant, (2012) ""Copper(II)-Ethylhexanoate,"" e-Eros (invited contribution), DOI: 10.1002/047084289X. B. W. Turnpenny, K. L. Hyman, S. R. Chemler (2012) ""Chiral Indoline Synthesis Via Enantioselective Intramolecular Copper-Catalyzed Alkene Hydroamination,"" Organometallics, 31, 7819-7822. F. C. Sequiera, S. R. Chemler (2012) ""Stereoselective Synthesis of Morpholines Via Copper(II)-Promoted Alkene Aminooxygenation,"" Org. Lett. 14, 4482-4485. S. Karyakarte, T. P. Smith, S. R. Chemler (2012) ""Stereoselective Isoxazolidine Formation Via Copper-Catalyzed Alkene Aminooxygenation,"" J. Org. Chem. 77, 7755-7760. Y. Miller, L. Miao, A. Hosseini, S. R. Chemler (2012) ""Copper-Catalyzed Intramolecular Alkene Carboetherification: Synthesis of Fused-Ring and Bridged-Ring Tetrahydrofurans,"" J. Am. Chem. Soc. 134, 12149-12156. F. C. Sequeira, M. T. Bovino, A. J. Chipre, S. R. Chemler (2012) ""Multigram Synthesis of a Chiral Substituted Indoline Via Copper-Catalyzed Alkene Aminooxygenation,"" Synthesis, 44, 1481-1484. M. T. Bovino, S. R. Chemler (2012), ""Atom Transfer as a New Solution for Catalytic Enantioselective Alkene Aminohalogenation / Cyclization,"" Angew. Chem. Int. Ed. 51, 3923-3927. T. W. Liwosz, S. R. Chemler (2012), ""Copper-Catalyzed Enantioselective Intramolecular Alkene Amination / Intermolecular Heck-type Coupling Cascade,"" J. Am. Chem. Soc. 134, 2020-2023.. M. C. Paderes, L. Belding, B. Fanovic, T. Dudding, J. B. Keister and S. R. Chemler (2012), ""Evidence for Alkene Cis-Aminocupration, an Aminooxygenation Case Study: Kinetics, EPR Spectroscopy and DFT Calculations,"" Chem. Eur. J. 18, 1711-1726. M. C. Paderes and S. R. Chemler (2011), ""Stereoselective Copper-Catalyzed Intramolecular Alkene Aminooxygenation: Effects of Substrate and Ligand Structure on Selectivity,"" Eur. J. Org. Chem. (Special Edition), 3679-3684. [Full Text PDF]