个人简介

Dr. Arbour is a Professor in the Department of Medical Genetics at UBC and an Affiliate Professor in the Division of Medical Sciences at the University of Victoria. Her clinical practice and research focuses on northern and Indigenous health issues as they pertain to genetics. Trained as both pediatrician and clinical geneticist (McGill University), her work as a clinician investigator integrates maternal-child health issues and the understanding of the genetic component to Aboriginal health of all ages. Dr. Arbour is currently also the clinical lead for Medical Genetics in the Department of Laboratory Medicine for the Vancouver Island Health Authority.

研究领域

Our research focuses on the health of Northern and Aboriginal populations while integrating the concepts of the CIHR Guidelines for health research involving Aboriginal People. Please see DNA on loan: issues to consider when carrying out genetic research with Canadian Aboriginal populations and Global Indigenous health research symposium report papers and presentations: Directions and themes in international Indigenous health research 2008 for more information. The work of our team has three main themes: exploring the genetic causes and understanding the clinical presentation of genetic conditions (Long QT Syndrome and Primary Biliary Cirrhosis, PBC) prevalent in BC First Nations; exploring the biological, nutritional and social determinants of early Inuit health; documenting and understanding the effects of the environment and other determinants on birth outcomes in BC, Yukon, Nunavut and the circumpolar world. There is a disproportionately high rate of Long QT Syndrome in the First Nations of Northern BC. Our primary goals have been to define the genetic basis, and understand the clinical phenotype in partnership with the community. Lee-Anna Huisman, a graduate student with our program, also set out to explore the impact of living with the condition on a daily basis. Primary biliary cirrhosis, an autoimmune liver disease, is the most common reason for referral for liver transplant in BC First Nations people. Largely affecting coastal Nations in a rate eight times that of the non-First Nations populations, we set out to understand the specific clinical features in this population and define guidelines for diagnosis of liver disease. Several BC First Nations families and individuals have joined our project, and linkage analysis is underway to define the genetic basis of the condition in this population. Through funding from a CIHR team grant and the work of a MSc student (Sorcha Collins), we were able to assess the frequency and whether the CPT1A P479Lvariant increases risk for infant mortality in the Inuit of Nunavut and Inuvialuit of NWT. Moreover, with this funding and new funding from the Nunavut government we worked with the Chief Medical Officer of Health (Dr. Geraldine Osborne) of Nunavut to review causes of infant mortality in Nunavut 1999-2008 and to develop a sustainable surveillance system, Nutaqqavut Health Information System within the Nunavut Public Health System that collects information to understand the determinants of health for infants and children of Nunavut. Furthermore, through funding from the First Nations and Inuit Health Branch of Health Canada, and in partnership with Inuit Tapiriit Kanatami, we are utilizing the data derived from the 2006 Aboriginal Children's survey to understand better how to prevent Sudden Infant Death Syndrome (SIDS) with public health promotion. This project, Looking to the Future: Early Inuit Health utilizes the infant and early child care giver responses to understand barriers to breast feeding, the types of chronic diseases of concern, and access to health care.

We are also interested in the determinants of birth outcomes with a focus on prevention. Anders Erickson (PhD student) is leading a CIHR funded project encompassing BC, Yukon and Alberta, determining whether proximity to environmental hazards increase the risk for adverse outcomes such as Intrauterine Growth Restriction (IUGR), prematurity, small for gestational age, and birth defects. This project builds in concept from other work we have been carrying out on exploring birth outcomes in Nunavut and now other circumpolar countries. Population genetics factors, nutrition, high rates of smoking in pregnancy may all affect birth outcomes in Northern populations. This on-going work, with national and international collaborators, is in part an activity of the International Union of Circumpolar Health Birth Defects and Birth Outcomes working group.

近期论文

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Foster WG, Evans JA, Little J, Arbour L, Moore A, Sauve R, León JA, Luo W. (2016) Human exposure to environmental contaminants and congenital anomalies: a critical review. Critical Reviews in Toxicology. 2016;1–26. DOI: 10.1080/10408444.2016.1211090 Erickson AC, Ostry A, Chan LHM, and Arbour L. (2016). The reduction of birth weight by fine particulate matter and its modification by maternal and neighbourhood-level factors: a multilevel analysis in British Columbia, Canada. Environmental Health. 15(51): 1-19. http://dx.doi.org/10.1186/s12940-016-0133-0 Erickson AC, Ostry A, Chan LHM, and Arbour L. (2016). Air pollution, neighbourhood and maternal-level factors modify the effect of smoking on birth weight: a multilevel analysis in British Columbia, Canada. BMC Public Health. In Press:TBA: TBA. Auger N, Fraser W, Arbour L, Healy-Profitós J, Drolet B. (2016). Preeclampsia and risk of infantile hemangioma. British Journal of Dermatology. doi: 10.1111/bjd.14958. [Epub ahead of print]. Bassil K, Skarsgard E, Yang J, Arbour L, Moineddin R, Brindle M, and Hazell E.(2016). Spatial Variability of Gastroschisis in Canada, 2006-2011: An Exploratory Analysis. Canadian Journal of public health. 103(2): 111-118. Predham S, Hathaway J, Hulait G, Arbour L, Lehman A. (2016). Patient Recall, Interpretation, and Perspective of an Inconclusive Long QT Syndrome Genetic Test Result.Journal of Genetic Counseling. 25(5): 1-9. http://dx.doi.org/10.1007/s10897-016-9991-4 Munday FA, Asuri S, McIntosh S, Jackson H, Tang A, and Arbour L. (2016). Increased corrected QT interval (QTc) in First Nations women of Northern British Columbia with Systemic Lupus Erythematosus (SLE). International Journal of Clinical Cardiology. 3(1): 3:072. Arbour L, Asuri S, Whittome B, Polanco F, and Hegele RA. (2015). The Genetics of Cardiovascular Disease in Aboriginal Populations. Canadian Journal of Cardiology. 31: 1094-1115. Skarsgard ED, Meaney C, Bassil K, Brindle M, Arbour L, Moineddin R, and Canadian Pediat Surg Network. (2015). Maternal Risk Factors for Gastroschisis in Canada. Birth Defects Research Part A-Clinical And Molecular Teratology. 103(2): 111-118. Auger N, Fraser WD, Healy-Profitós J, and Arbour L. (2015). Association between preeclampsia and congenital heart defects.JAMA. 314(15): 1588-1598. Shariff F, Peters P, Arbour L, Greenwood M, Skarsgard E, and Brindle M. (2015). Maternal and community predictors of gastroschisis and congenital diaphragmatic hernia in Canada. Pediatric Surgery International.3(11): 1055-60. Janzen M, Sanatani S, Gibbs KA, Mohammed SS, Hathaway J, Arbour L, and Krahn AD. (2014). Inherited heart rhythm disorders: Diagnostic dilemmas after the sudden death of a young family member. Journal of Nursing Education and Practice. 4(3): 225. Jackson H, McIntosh S, Whittome B, Asuri S, Casey B, Kerr C, Tang A, Arbour L. (2014). LQTS in Northern BC: homozygosity for KCNQ1 V205M presents with a more severe cardiac phenotype but with minimal impact on auditory function.Clinical Genetics. 86(1): 85-90. Caron NR,Thira SA, McCormick RM, Butler-Walker JJE, Lalonde CE, Arbour L, Vedan RW, Jovel EM. (2014). Capacity Interrupted: The Kloshe Tillicum Graduate Student Training Experience. Canadian Journal of Native Education. 37(1): 165-192. Erickson, A and Arbour L. (2014). The Shared Pathoetiological Effects of Particulate Air Pollution and the Social Environment on Fetal-Placental Development. Journal of Environmental and Public Health. 2014(doi:): 10.1155/2014/901017. Krahn AD, Sanatani S, Gardner MJ, Arbour L. (2013). Inherited heart rhythm disease: negotiating the minefield for the practicing cardiologist.The Canadian journal of cardiology. 29(1): 122-25. Khoo C, Chakrabarti S, Arbour L, Krahn AD. (2013). Recognizing life-threatening causes of syncope.Cardiology clinics. 31(1): 51-66. Arbour L. (2013). Developing Healthy Communities: Understanding maternal child health determinants in Nunavut. International Journal of Circumpolar Health. 72(Supplemt 1): 51-55. Erickson AC, Arbour LT. (2012). Heavy smoking during pregnancy as a marker for other risk factors of adverse birth outcomes: a population-based study in British Columbia, Canada.BMC public health. 12: 102. Sinclair GB, Collins S, Popescu O, McFadden D, Arbour L, Vallance HD. (2012). Carnitine palmitoyltransferase I and sudden unexpected infant death in British Columbia First Nations.Pediatrics. 130(5): e1162-9. Tsang E, Rupps R, McGillivray B, Eydoux P, Marra M, Arbour L, Langlois S, Friedman JM, Zahir FR. (2012). Life-history chronicle for a patient with the recently described chromosome 4q21 microdeletion syndrome.American journal of medical genetics. Part A. 158A(10): 2606-9. Niederhoffer KY, Peñaherrera M, Pugash D, Rupps R, Arbour L, Tessier F, Choufani S, Zhao C, Manokhina I, Shuman C, Robinson WP, Weksberg R, Boerkoel CF. (2012). Beckwith-Wiedemann syndrome in sibs discordant for IC2 methylation.American journal of medical genetics. Part A. 158A(7): 1662-9. Collins SA, Surmala P, Osborne G, Greenberg C, Bathory LW, Edmunds-Potvin S, Arbour L. (2012). Causes and risk factors for infant mortality in Nunavut, Canada 1999-2011.BMC pediatrics. 12: 190. Lauson S, McIntosh S, Obed N, Healey G, Asuri S, Osborne G, Arbour L. (2011). The development of a comprehensive maternal-child health information system for Nunavut-Nutaqqavut (Our Children).International journal of circumpolar health. 70(4): 363-72.