Reisman, Sarah E. - California Institute of Technology, Caltech - Division of Chemistry and Chemical Engineering

个人简介

B.A., Connecticut College, 2001; Ph.D., Yale University, 2006. Caltech, 2008-; Executive Officer Sarah Reisman was born and raised in Bar Harbor, Maine. She attended Connecticut College in New London, CT, where she developed a passion for organic synthesis working in the laboratory of Prof. Timo Ovaska, and graduated with honors in 2001. In the fall of that year, Sarah enrolled in graduate studies at Yale University and joined the research group of Prof. John Wood. She earned her Ph.D. in chemistry in 2006; her thesis detailed the total synthesis of the natural product welwitindolinone A isonitrile. For her postdoctoral work, Sarah pursued studies in the field of asymmetric catalysis as an NIH fellow, working with Prof. Eric Jacobsen at Harvard University.

研究领域

The Reisman Laboratory conducts research in the field of natural product synthesis, with an emphasis on the development of new synthetic methods that facilitate the construction of complex molecules.

近期论文

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Nickel-Catalyzed Asymmetric Reductive Cross-Coupling Between Vinyl and Benzyl Electrophiles. Cherney, A. H.; Reisman, S. E. J. Am. Chem. Soc. 2014, 136, 14365. DOI: 10.1021/ja508067c. Enantioselective Total Synthesis of (—)-Lansai B and (+)-Nocardioazines A and B. Wang, H.; Reisman, S. E. Angew. Chem. Int. Ed. 2014, 53, 6206. DOI: 10.1002/anie.201402571. This synthesis was featured in a September 2014 post on The Offset, which can be found here. A Unified Strategy for the Synthesis of (—)-Maoecrystal Z, (—)-Trichorabdal A, and (—)-Longikaurin E. Yeoman, J. T. S.; Cha, J. Y.; Mak, V. W.; Reisman, S. E. Tetrahedron. 2014, 70, 4070. DOI: 10.1016/j.tet.2014.03.071. Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders. Hsiao, E. Y.; McBride, S. W.; Hsien, S.; Sharon, G.; Hyde, E. R.; McCue, T.; Codelli, J. A.; Chow, J.; Reisman, S. E.; Petrosino, J. F.; Patterson, P. H.; Mazmanian, S. K. Cell 2013, 155, 1451. DOI: 10.1016/j.cell.2013.11.024. Pd-Catalyzed Fukuyama Cross-Coupling of Secondary Organozinc Reagents for the Direct Synthesis of Unsymmetrical Ketones. Cherney, A. H.; Reisman, S. E. Tetrahedron 2013, 70, 3259. DOI: 10.1016/j.tet.2013.11.104. Recent Developments in the Catalytic, Asymmetric Construction of Pyrroloindolines Bearing All-Carbon Quaternary Stereocenters. Repka, L. M.; Reisman, S. E. J. Org. Chem. 2013, 78, 12314. DOI: 10.1021/jo4017953. A Unified Strategy to ent-Kauranoid Natural Products: Total Syntheses of (—)-Trichorabdal A and (—)-Longikaurin E. Yeoman, J. T. S.; Mak, V. W.; Reisman, S. E. J. Am. Chem. Soc. 2013, 135, 11764. DOI: 10.1021/ja406599a. Catalytic Asymmetric Reductive Acyl Cross-Coupling: Synthesis of Enantioenriched Acyclic α,α-Disubstituted Ketones. Cherney, A. H.; Kadunce, N. T.; Reisman, S. E. J. Am. Chem. Soc. 2013, 135, 7442. DOI: 10.1021/ja402922w. α-Diazo-β-Ketonitriles: Uniquely Reactive Substrates for Arene and Alkene Cyclopropanation. Nani, R. R.; Reisman, S. E. J. Am. Chem. Soc. 2013, 135, 7304. DOI: 10.1021/ja401610p. Direct, Enantioselective Synthesis of Pyrroloindolines and Indolines From Simple Indole Derivatives. Ni, J.; Wang, H.; Reisman, S. E. Tetrahedron 2013, 69, 5622. DOI: 10.1016/j.tet.2013.04.003. Copper-catalyzed Diastereoselective Arylation of Tryptophan Derivatives: Total Synthesis of (+)-Naseseazines A and B. Kieffer, M. E.; Chuang, K. V.; Reisman, S. E. J. Am. Chem. Soc. 2013, 135, 5557. DOI: 10.1021/ja4023557. Catalytic Asymmetric Synthesis of Highly Substituted Pyrrolizidines. Lim, A. D.; Codelli, J. A.; Reisman, S. E. Chem. Sci. 2013, 4, 650. DOI: 10.1039/C2SC21617E. A Copper-Catalyzed Arylation of Tryptamines for the Direct Synthesis of Aryl Pyrroloindolines. Kieffer, M. E.; Chuang, K. V.; Reisman, S.E. Chem. Sci 2012, 3, 3170. DOI: 10.1039/C2SC20914D. Rapid Construction of the Aza-Propellane Core of Acutumine via a Photochemical [2 + 2] Cycloaddition Reaction. Navarro, R.; Reisman, S.E. Org. Lett. 2012, 14, 4354. DOI: 10.1021/ol3017963. Enantioselective Synthesis of Tryptophan Derivatives by a Tandem Friedel–Crafts Conjugate Addition/Asymmetric Protonation Reaction. Kieffer, M. E.; Repka, L. M.; Reisman, S.E. J. Am. Chem. Soc. 2012,134, 5131. DOI: 10.1021/ja209390d. Enantioselective Total Synthesis of (−)-Acetylaranotin, a Dihydrooxepine Epidithiodiketopiperazine. Codelli, J. A.; Puchlopek, A. L. A.; Reisman, S.E. J. Am. Chem. Soc. 2012, 134, 1930. DOI: 10.1021/ja209354e. This synthesis was featured in November C&E News Article, found here. Buchner and Beyond: Arene Cyclopropanation as Applied to Natural Product Total Synthesis. Reisman, S. E.; Nani, R. R., Levin, S. Synlett, 2011, 17, 2437. DOI: 10.1055/s-0031-128952. A Concise Total Synthesis of (–)-Maoecrystal Z. Cha, J. Y.; Yeoman, J. T. S.; Reisman, S .E. J. Am. Chem. Soc. 2011, 133, 14965. DOI: 10.1021/ja2073356. This synthesis was featured in a September 2011 post on Totally Synthetic, found here, and featured in Synfacts 2011, 12, 1271, which can be found here. Short, Enantioselective Total Syntheses of (–)-8-Demethoxyrunanine and (–)-Cepharatines A, C, and D. Chuang, K.V.; Navarro, R.; Reisman, S.E. Angew. Chem. Int. Ed. 2011, 50, 9447. DOI:10.1002/anie.201104487. This synthesis was featured in Synfacts 2012, 8, 14, which can be found here. Benzoquinone-Derived Sulfinyl Imines as Versatile Intermediates for Alkaloid Synthesis: Total Synthesis of (–)-3-Demethoxyerythratidinone. Chuang, K.V.; Navarro, R.; Reisman, S. E. Chem. Sci. 2011, 2 (6), 1086. DOI:10.1039/c1sc00095k.