Brock, Hugh W - University of British Columbia

个人简介

Director of the Genetics Graduate Program; B.Sc., U.B.C.; D.Phil., Oxford; EMBO Post-doctoral Fellow, Univ of Paris (1981); Jane Coffin Childs Fellow, Univ. of Washington (1981); Associate Member, Medical Genetics Dept., UBC; Associate Member, Biotechnology Lab., UBC; President of the Genetics Society of Canada 2002-2003.

研究领域

Cell and Developmental Biology

近期论文

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Mohd-Sarip, A., Lagarou, A., Doyen, C.M., van der Knaap, J.A., Aslan, U., Bezstarosti, K., Yassin, Y., Brock, H.W., Demmers, J.A., C.P. Verrijzer. 2012. Transcription-independent function of Polycomb group protein PSC in cell cycle control. Science 336: 744-7 Petruk, S., Johnston, D.M., Sedkov, Y., Hodgson, J.W., Black, K.L., Beck, S., Cananni, E., Brock, H.W., A. Mazo. 2012. TrxG and Pcg proteins but not methylated histones remain associated with their response elements during DNA replication. Cell 150:922-33 Hodgson, J.W., H.W. Brock. 2011. Are Polycomb Group bodies gene silencing factories. Cell 144: 170-171 Beck, S.A., O’Dor, E., Catching, A., Brock, H.W. 2010. Cell cycle defects in polyhomeotic mutants are caused by abrogation of the DNA damage checkpoint. Dev. Biol. 339:320-328 Fisher CL, Pineault N, Brookes C, Helgason CD, Ohta H, Bodner C, Hess JL, Humphries RK, Brock HW. 2010. Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia. Blood 115:38-46 Fisher, C.L. Lee, I., Komljenovic, I., Bozza, S., Pineault, N. ,Bloyer, S., Brookes, C., Chevalier, J., Dahl, A, Helgason, C., Hess, J.L., Humphries, R.K., and Brock, H.W. 2010. Additional sex combs-like 1 belongs to the enhancer of trithorax and Polycomb Group and genetically interacts with Cbx2 in mice. Developmental Biology 337, 9-15 Brock, H.W., Hodgson, J.W., Petruk, S., and Mazo, A. 2009. Regulatory non-coding RNAs at Hox loci. Biochem. Cell Biol. 8,:27-34 Sinclair, D.A.R., Syrzycka. M., Macauley, M. Rastgardani, T. , Komljenovic, I. , Vocadlo, D., Brock, H.W., Honda, B. 2009. Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc). Proc. Natl. Acad. Sci USA 106,13427-13432 Hallson, G. Syrzycka, M., Beck, S.A., Kennison, J.A., Dorsett, D., Page, S.L., Hunter, S.M., Keall, R., Warren, W.D., Brock, H.W., Sinclair, D.A.R., and Honda, B.M. 2008. The Drosophila cohesin subunit Rad21 is a trithorax group (trxG) protein. Proc. Natl. Acad. Sci USA 105, 12405-12410 Kim, K, Choi, J., Kim, H. Levens, D., Kohno, K., Johnson, E.M., Brock, H.W., An, W. 2008. Isolation and characterization of a novel H1. 2 complex that acts as a repressor of p53-mediated transcription. J. Biol. Chem. 283, 9113-9126 Mazo, A., Hodgson, J.W., Petruk, S., Sedkov, Y. and Brock, H.W. 2007. Transcriptional interference: an unexpected layer of complexity in gene regulation J. Cell Science 120, 2755-2761 O’Dor, E. Beck, S., and Brock, H.W. 2006. Polycomb group mutants exhibit mitotic defects in syncytial cell cycles of Drosophila embryos. Dev. Biol. 290, 312-322 Petruk, S., Sedkov, Y., Riley, K.M., Hodgson, J., Schweisguth, F., Hirose, S., Jaynes, J.B., Brock, H.W. and Mazo, A. 2006. Transcriptional elongation of non-coding bxd RNAs promoted by the Trithorax TAC1 complex represses Ubx by a transcriptional interference mechanism. Cell 127, 1209-1221