个人简介

B.S., Koc University, Istanbul, Turkey (2003) Ph.D., University of Pennsylvania, Philadelphia, PA (2008) Postdoctoral Fellow, Dana Farber Cancer Institute / Harvard Medical School, Boston, MA (2009-2013)

研究领域

Analytical Chemistry/Medicinal Chemistry and Chemical Biology

Lipids are a broad class of biomolecules whose primary role is to form the permeability barriers, which define cellular borders and compartments within them. Increasingly, they are recognized to play critical roles as signaling molecules both within cells and between cells, as lipids themselves, or following transformation by hydrolysis, oxidation or other modifications. As a chemical biologist, my research focuses on investigating the role of lipids and lipid-derived metabolites in different cellular processes, which I think provide a major and unexplored area of biochemistry that is ripe for discovery and therapeutic applications. Apoptosis (programmed cell death) and senescence (permanent cessation of division) are two natural processes that terminate the proliferative life of an animal cell. They play central roles in normal aging, cancer formation and progression, and response to cancer chemotherapy. Apoptosis has been heavily studied, and protein-based pathways that regulate it are well understood. Senescence, in contrast, has only recently been recognized as a major event in the life of tissue cells, and is much less well understood. Research on apoptosis and senescence have mostly been confined to key protein players. The role of lipids in these cellular events are largely unknown, and interest has focused on a small number of molecules in the sphingolipid family. We aim to construct comprehensive maps of the lipidome at different stages of cell life cycle, identify novel lipids and infer/define their functional relevance in apoptosis and senescence. The findings of these projects will not only provide a better understanding of the nature and involvement of a complex class of compounds in fundamental biological events but could also potentially provide future therapeutic applications for aging, cancer and inflammatory disease.

近期论文

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Atilla-Gokcumen, G. E, Eggert, U. S. (To be published in October 2014) A comparative LC-MS based profiling approach to analyze lipid composition in tissue culture systems. In D. Owen (Ed.) Methods in Membrane Lipids New York, NY:Springer. Muro E.*, Atilla-Gokcumen G.E.*, Eggert, U. S. (2014) Lipids in cell biology – how can we understand them better? Mol Bio Cell 5;25(12):1819-1823 (*Contributed equally) Atilla-Gokcumen G. E.*, Muro E.*, Relat-Goberna J., Sasse S., Bedigian A.V., Coughlin, M., Garcia-Manyes, S., Eggert, U. S. (2014) Dividing cells regulate their lipid composition and localization. Cell 156, 428-439. (*Contributed equally). Atilla-Gokcumen, G. E., Bedigian, A. V., Sasse, S., and Eggert, U. S. (2011) Inhibition of glycosphingolipid biosynthesis induces cytokinesis failure, J Am Chem Soc 133, 10010-10013. Atilla-Gokcumen, G. E.*, Castoreno, A. B.*, Sasse, S., and Eggert, U. S. (2010) Making the cut: the chemical biology of cytokinesis, ACS Chem Biol 5, 79-90. (*Contributed equally). Feng, L., Geisselbrecht, Y., Blanck, S., Wilbuer, A., Atilla-Gokcumen, G. E., Filippakopoulos, P., Kraling, K., Celik, M. A., Harms, K., Maksimoska, J., Marmorstein, R., Frenking, G., Knapp, S., Essen, L. O., and Meggers, E. (2011) Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors, J Am Chem Soc 133, 5976-5986. Atilla-Gokcumen, G. E., Di Costanzo, L., and Meggers, E. (2011) Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3b, J Biol Inorg Chem 16, 45-50. Atilla-Gokcumen, G. E., Pagano, N., Streu, C., Maksimoska, J., Filippakopoulos, P., Knapp, S., and Meggers, E. (2008) Extremely tight binding of a ruthenium complex to glycogen synthase kinase 3, ChemBioChem 9, 2933-2936. Smalley, K. S., Contractor, R., Haass, N. K., Kulp, A. N., Atilla-Gokcumen, G. E., Williams, D.S., Bregman, H., Flaherty, K. T., Soengas, M. S., Meggers, E., and Herlyn, M. (2007) An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells, Cancer Res 67, 209-217 Atilla-Gokcumen, G. E., Williams, D. S., Bregman, H., Pagano, N., and Meggers, E. (2006) Organometallic compounds with biological activity: a very selective and highly potent cellular inhibitor for glycogen synthase kinase 3, ChemBioChem 7, 1443-1450.