Giaever, Guri - University of British Columbia - Faculty of Pharmaceutical Sciences

个人简介

Dr. Guri Nina Giaever completed a bachelor of science in electrical engineering at Brown University in Providence, Rhode Island and a doctor of philosophy in biophysics at Harvard University in Cambridge, Massachusetts. She was also a National Institutes of Health postdoctoral fellow, senior genome scientist at the Stanford Genome Technology Center in Palo Alto, California. In that role, Dr. Giaever started the HIPHOP chemogenomics laboratory. Prior to joining UBC, Dr. Giaever was an associate professor and Tier II CRC chair in chemical biology at the Donnelly Centre at the University of Toronto. Her teaching areas of interest include drug discovery, genetics, medicinal chemistry, and functional genomics.

研究领域

The primary research objectives of Dr. Giaever's lab include screening known and novel drugs to understand their precise mechanisms of action. The unique, genome-wide assays have the ability to uncover drug targets and mechanisms of drug action in a cellular context. Specifically, genome-wide assays are employed that allow the identification of all genes required for growth in the presence of drug to identify specific genes perturbed by a drug with a focus on the model organism yeast S. cerevisiae. Her experimental approach reports a genome-wide view of cellular response to compounds, providing a rich resource for the discovery of the relationship between genes, drugs and biological processes. In an orthogonal approach, Dr. Giaever's lab recently established a genome-wide screen for alleles involved in drug resistance, employing NGS (next-generation sequencing) technologies. The lab continues to improve and expand its automated technologies, including the development of robust bioinformatic and cheminformatics methodologies. Dr. Giaever is also translating findings to patient samples.

近期论文

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Mapping the cellular response to small molecules using chemogenomic fitness signatures., Lee, Anna Y., St Onge Robert P., Proctor Michael J., Wallace Iain M., Nile Aaron H., Spagnuolo Paul A., Jitkova Yulia, Gronda Marcela, Wu Yan, Kim Moshe K., et al. , Science, 2014 Apr 11, Volume 344, Issue 6180, p.208-11, (2014) The yeast deletion collection: a decade of functional genomics., Giaever, Guri, and Nislow Corey , Genetics, 2014 Jun, Volume 197, Issue 2, p.451-65, (2014) PITPs as targets for selectively interfering with phosphoinositide signaling in cells., Nile, Aaron H., Tripathi Ashutosh, Yuan Peihua, Mousley Carl J., Suresh Sundari, Wallace Iain M., Shah Sweety D., Pohlhaus Denise Teotico, Temple Brenda, Nislow Corey, et al. , Nat Chem Biol, 2014 Jan, Volume 10, Issue 1, p.76-84, (2014) Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors., Sukhai, Mahadeo A., Prabha Swayam, Hurren Rose, Rutledge Angela C., Lee Anna Y., Sriskanthadevan Shrivani, Sun Hong, Wang Xiaoming, Skrtic Marko, Seneviratne Ayesh, et al. , J Clin Invest, 2013 Jan, Volume 123, Issue 1, p.315-28, (2013) Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia., Skrtic, Marko, Sriskanthadevan Shrivani, Jhas Bozhena, Gebbia Marinella, Wang Xiaoming, Wang Zezhou, Hurren Rose, Jitkova Yulia, Gronda Marcela, MacLean Neil, et al. , Cancer Cell, 2011 Nov 15, Volume 20, Issue 5, p.674-88, (2011)