Chen, Tim - University of British Columbia - Faculty of Pharmaceutical Sciences

个人简介

Dr. Tim Chen completed an honours bachelor of sciences in biology and pharmacology (co-op) at McMaster University, and a doctor of philosophy in cardiovascular physiology and pharmacology at the University of Calgary. He followed this with a postdoctoral fellowship in neurology at Baylor College of Medicine. Dr. Chen is an assistant professor in the Faculty of Pharmaceutical Sciences at UBC.

研究领域

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Dr. Chen’s research is focused on ion channels and ion channel variants in co-morbid channelopathies. His research takes a multidisciplinary approach, integrating large-scale genomic studies, molecular biology, protein biochemistry, electrophysiology, pharmacology and physiology to study the dysfunction of ion channels in excitability disorders. These studies are critical to revealing disease-causing ion channel variants shared by disparate tissues underlying common and rare co-morbid excitability disorders. These channelopathies include those in the heart (cardiac arrhythmias; SUDEP), skeletal muscle (myotonia), pancreas (diabetes), and blood vessels (stroke/hypertension). The objectives of Dr. Chen’s work are to (1) translate profiles of ion channel gene variants or ‘channotypes’ into clinically useful markers for diagnosis, prognosis and effective pharmacotherapy selection, and (2) to identify possible targets for known and novel therapeutic intervention informed by shared disease-causing mechanisms across excitable tissues.