Eltis, Lindsay - University of British Columbia - Department of Biochemistry and Molecular Biology

研究领域

Microorganisms have evolved an astoundingly versatile armamentarium of catabolic enzymes and pathways to degrade the vast array of organic compounds that occur in the environment. These catabolic activities constitute an essential link in the global carbon cycle, and as such are critical to maintaining the health of the biosphere. In addition to their fundamental importance, microbial catabolic enzymes are of tremendous practical importance. First, they represent an enormous, barely tapped source of biocatalysts for green chemistry and bioremediation applications. Second, such enzymes can be important targets for novel therapeutics to treat infectious diseases. Research in the Eltis lab seeks to understand microbial enzymes and pathways involved in the degradation of natural and man-made compounds. We currently study the following systems: Biocatalytic applications: PCB- and biphenyl-degrading enzymes Nitrile degradation in Rhodococcus The degradation of explosives by actinomycetes Human health applications: Cholesterol catabolic enzymes of Mycobacterium tuberculosis. Viral 3C proteases

近期论文

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Characterization of an extradiol dioxygenase involved in the catabolism of lignin-derived biphenyl. Kuatsjah E, Chen HM, Withers SG, Eltis LD. FEBS Lett. 2017 Mar 1. doi: 10.1002/1873-3468.12611. [Epub ahead of print] PMID: 28247503 Similar articles Select item 28169340 Enhanced delignification of steam-pretreated poplar by a bacterial laccase. Singh R, Hu J, Regner MR, Round JW, Ralph J, Saddler JN, Eltis LD. Sci Rep. 2017 Feb 7;7:42121. doi: 10.1038/srep42121. PMID: 28169340 Free PMC Article Similar articles Select item 27126051 Characterization of key triacylglycerol biosynthesis processes in rhodococci. Amara S, Seghezzi N, Otani H, Diaz-Salazar C, Liu J, Eltis LD. Sci Rep. 2016 Apr 29;6:24985. doi: 10.1038/srep24985. PMID: 27126051 Free PMC Article Similar articles Select item 26953337 Structural Basis of the Enhanced Pollutant-Degrading Capabilities of an Engineered Biphenyl Dioxygenase. Dhindwal S, Gomez-Gil L, Neau DB, Pham TT, Sylvestre M, Eltis LD, Bolin JT, Kumar P.