Finlay, Brett - University of British Columbia - Department of Biochemistry and Molecular Biology

个人简介

University of Alberta, 1986, PhD

研究领域

The human body routinely encounters many threatening infectious agents, including Salmonella and pathogenic E. coli. Most Salmonella and E. coli infections arise from oral ingestion of tainted food or water and are a significant cause of disease and death in animals and humans worldwide. Salmonella bacteria cause typhoid fever, a frequently fatal infectious condition that is common in the developing world. It also causes gastroenteritis, a type of food poisoning characterized by abdominal pain, fever, vomiting, and diarrhoea. Salmonella species are close relatives of E. coli, which cause numerous diseases including meningitis, urinary tract infections diarrhea and fatal kidney disease. The bacteria infect and interfere with normal function of cells in the stomach and intestine to cause disease. However, the molecular mechanism of how these pathogens adhere, enter, survive, replicate, and exit host cells is not well defined. Although attacks from infectious agents are common, extremely few actually lead to infection. The body possesses a very powerful and efficient set of conserved mechanisms that deal rapidly with nearly all microbial infectious agents. This system, called “innate immunity”, is the primary defence mechanism of most multicellular organisms. To cause an infection, a successful pathogen must overcome innate immunity. Research in my lab is focussed on understanding bacterial pathogenesis from the perspective of both pathogen and host. In addition to studying the molecular mechanisms of pathogenicity for Salmonella and E. coli, we are interested in gaining further understanding of the critical human innate responses to microbial infection. By applying techniques from several disciplines including microbiology, cell biology, biochemistry, immunology, genomics and bioinformatics we have begun to understand the molecular mechanisms of microbial pathogenesis, ultimately allowing development of novel vaccines, diagnostics, and therapeutics that can be used to control infections caused by a wide range of globally important pathogens.

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Croxen M.A., Law R.J., Scholz R., Keeney K.M., Wlodarska M., Finlay BB. (Oct) 2013. Recent Advances in Understanding Enteric Pathogenic Escherichia coli. Clin Microbiol Rev. 2013 Oct;26(4):822-880. Amaral J.J., Antunes L.C., de Macedo C.S., Mattos K.A., Han J., Pan J., Candéa A.L., Henriques M.d., Ribeiro-Alves M., Borchers C.H., Sarno E.N., Bozza P.T., Finlay BB., Pessolani M.C. (Aug) 2013. Metabonomics reveals drastic changes in anti-inflammatory/pro-resolving polyunsaturated Fatty acids-derived lipid mediators in leprosy disease. PLoS Negl Trop Dis. 2013 Aug 15;7(8):e2381. Marchiando A.M., Ramanan D., Ding Y., Gomez L.E., Hubbard-Lucey V.M., Maurer K., Wang C., Ziel J.W., van Rooijec N., Nuñez G., Finlay BB., Mysorekar I.U., Cadwell K. (Aug) 2013. A Deficiency in the Autophagy Gene Atg16L1 Enhances Resistance to Enteric Bacterial Infection. Cell Host Microbe. 2013 Aug 14;14(2):216-24. Bhavsar A.P., Brown N.F., Stoepel J., Wiermer M., Martin D.D., Hsu K.J., Imami K., Ross C.J., Hayden M.R., Foster L.J., Li X., Hieter P., Finlay BB. (Jul) 2013. The Salmonella Type III Effector SspH2 Specifically Exploits the NLR Co-Chaperone Activity of SGT1 to Subvert Immunity. PLoS Pathog. 2013 Jul;9(7):e1003518. Buckner M.M., Antunes L.C., Gill N., Russell S.L., Shames S.R., Finlay BB. (Jul) 2013. 15-Deoxy-Δ(12.14)-Prostaglandin J2 Inhibits Macrophage Colonization by Salmonella enterica Serovar Typhimurium. PLoS One. 2013 Jul 26;8(7):e69759. Donnenberg M.S., Finlay BB. (Jul) 2013. Combating enteropathogenic Escherichia coli (EPEC) infections: the way forward. Trends Microbiol. 2013 Jul;21(7):317-9. Brown E.M. Sadarangani M., Finlay BB. (Jul) 2013. The role of the immune system in governing host-microbe interactions in the intestine. Nat Immunol. 2013 Jul:14(7). Sal-Man N., Setiaputra D. Scholz R., Deng W., Yu A.C., Strynadka N.C., Finlay BB. (Mar) 2013. EscE and EscG are co-chaperones for the type III needle protein EscF of enteropathogenic E. coli. J Bacteriol. 2013 Jun;195(11):2481-9. Imami K., Bhavsar A.P., Yu H., Brown N.F., Rogers L.D., Finlay BB., Foster L.J. (Feb) 2013. Global impact of Salmonella pathogenicity island 2-secreted effectors on the host phosphoproteome. Mol Cell Proteomics. 2013 Jun;12(6):1632-43. Law R.J., Gur-Arie L., Rosenshine I., Finlay BB. (Mar) 2013. In vitro and in vivo model systems for studying enteropathogenic Escherichia coli infections. Cold Spring Harb Perspect Med. 2013 Mar 1;3(3):a009977. Olsen R.L., Echtenkamp F., Cheranova D. Deng W., Finlay BB., Hardwidge P.R. (Apr) 2013. The enterojemorrhagic Escherichia coli effector protein NleF binds mammaliam Tmp21. Vet Microbiol. 2013 May 31;164(1-2):164-70. Keeney K.M., Finlay BB. (Jan) 2013. Microbiology: EHEC downregulates virulence in response to intestinal fucose. Curr. Biol. 2013 Feb 4;23(3): R108-10. Backhed F., Fraser C.M., Ringel Y., Sanders M.E., Sartor R.B., Sherman P.M., Versolovic J., Young V., Finlay BB. (Nov) 2012. Defining a healthy human gut microbiome: Current concepts, future directions and clinical applications. Cell-Host Microbe. 2012 Nov 15;12(5):611-22. Gill N., Ferreira R.B., Antunes L.C., Willing B.P., Sekirov I., Al-Zahrani F., Hartmann M., Finlay BB. (Oct) 2012. Neutrophil elastase alters the gut microbiota resulting in enhanced Salmonella colonization. PLoS One, 2012;7(11):e49646. Kumar N.S., Amandoron E.A., Cherkasov A., Finlay BB., Gong H., Jackson L., Kaur W., Lian T., Moreau A., Labriere C., Reiner N.E., See R.H., Strynadka N.C., Thorson L., Wong E.W., Worral L., Zoraghi R., Young R.N. (Dec) 2012. Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents. Bioorg Med Chem. 2012 Dec 15;20(24):7069-82. Menendez A., Willing B.P., Montero M., Wlodarska M., So C.C., Bhiner G., Vallance B.A., Finlay BB. (Sept) 2012. Bacterial stimulation of the TLR-MyD88 pathway modulates the homeostatic expression of ileal paneth cell α-Defensins. J Innate Immun. 2013;5(1):39-49. Karch H., Denamur E., Dobrindt U., Finlay BB., Hengge R., Johannes L., Ron E.Z., Tonjum T., Sansonetti P.J., Vicente M.(Sept) 2012. The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak. EMBO Mol Med. 2012 Sep;4(9):841-8. Prehna G., Li Y., Stoynov N., Okon M., Vukovic M., McIntosh L.P., Foster L.J., Finlay BB., Stynadka N.C. (Sept) 2012. The Zinc Regulated Antivirulence Pathway of Salmonella is a Multi-protein Immunoglobulin Adhesion System. J Biol Chem.2012 Sep 21;287(39):32324-37. Cortés-Vieyra R., Bravo-Patiño A., Valdez-Alarcón J.J., Cajero-Juárez M., Finlay BB., Baizabal-Aguirre V.M. (June) 2012. Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens. J Inflamm (Lond). 2012 Jun 12;9(1):23. Russell, S., Finlay BB. (Oct) 2012. The impact of gut microbes in allergic diseases. Curr Opin Gastroenterol, 2012 Nov;28(6):563-9. (Review) Deng W., Yu H.B., de Hoog C.L., Stoynov N., Li Y., Foster L.J., Finlay BB. (Sept) 2012. Quantitative proteomic analysis of type III secretome of enteropathogenic Escherichia coli reveals an expanded effector repertoire for attaching/effacing bacterial pathogens. Mol Cell Proteomics. 2012 Sep;11(9):692-709. van der Heijden, J., Finlay BB. (June) 2012. Type III effector-mediated processes in Salmonella infection. Future Microbiol. 2012 Jun;7:685-703. Arrieta M.C., Finlay BB. (June) 2012. The commensal microbiota drives immune homeostasis. Front Immunol. 2012;3:33. Achtman, A.H., Pilat S., Law C.W., Lynn D.J., Janot L., Mayer M.L., Ma S., Kindrachuk J., Finlay BB., Brinkman F.S., Smyth G.K., Hancock R.E., Schofield L. (May) 2012. Effective adjunctive therapy by an innate defense regulatory peptide in a pre-clinical model of severe malaria. Science Transl Med., 2012 May 23;4(135):135ra64. Liu Z., Zaki M.H., Vogel P., Gurung P., Finlay BB., Deng W., Lamkanfi M., Kanneganti T.D. (Mar) 2012. The role of inflammasomes in host defense against Citrobacter rodentium infection. J Biol Chem. 2012 May 11;287(20):16955-64.